Mean platelet volume levels in patients with overt hypothyroidism before and after levothyroxine treatment

Atile, Neslihan Soysal

doi:10.4183/aeb.2012.607

Cited by 8 publications

(9 citation statements)

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“…In the present study, there was a significant positive correlation between FT4 and MPV in hypothyroid patients compared to controls, but no correlations were found with TSH and FT3. This is in agreement with a recent study by Atile et al (32), who reported the absence of association between MPV levels and TSH and FT3 in hypothyroid patients. Limited and conflicting data on the association between thyroid function and MPV have been reported in small-scale case-control studies (18).…”

Section: Discussionsupporting

confidence: 94%

“…Limited and conflicting data on the association between thyroid function and MPV have been reported in small-scale case-control studies (18). However, the potential usefulness of MPV as a prognostic marker for venous thromboembolism and various types of arterial thrombosis was concluded in a population-based metanalysis, making it acceptable as a new risk factor for atherosclerosis (32).…”

Section: Discussionmentioning

confidence: 99%

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Lipoprotein (a), Lipid Profile and Mean Platelet Volume in Hypothyroid Patients in Sana'a, Yemen: A Case-Control Study

2016

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Objectives: This study aimed to measure lipoprotein (a) [Lp(a)], lipid profile and mean platelet volume (MPV) in hypothyroid patients compared to healthy controls.Methods: An unmatched case-control study was conducted involving 100 subjects (50 overt hypothyroidism patients and 50 healthy controls admitted to the University of Science and Technology Hospital, Al-Thawra Hospital and Al-Jomhori Hospital- Sana'a, Yemen during the period from May 2013 to March 2014. Data were collected by in-person interview using a structured questionnaire followed by weight and height measurements. Fresh blood samples were collected and analyzed using electrochemiluminescent, spectrophotometric and immunoturbidimetric methods for estimating Lp(a), lipid profile and MPV parameters.Results: Hypothyroid patients had a significantly higher concentration of Lp(a) compared to the control. Total cholesterol (TC), triglycerides and low-density lipoprotein-cholesterol (LDL-C) levels were also significantly higher in hypothyroid patients. Serum level of free triiodothyronine (FT3) was negatively correlated with Lp(a), TC and LDL-C (r=–0.380, p=0.007; r=–0.354, p=0.012; r=–0.350, p=0.013, respectively). However, serum thyroid-stimulating hormone was positively correlated with Lp(a), TC and LDL-C (r=0.344, p=0.015; r=0.299, p=0.035; r=0.405, p=0.004, respectively) among hypothyroid patients. MPV levels, on the other hand, showed a strong positive correlation with (r=0.611, p=0.001).Conclusions: These findings indicate that overt hypothyroidism patients tend to have increased Lp(a) and atherogenic lipids that may contribute to increasing risk of atherosclerosis. However, hypothyroid patients showed no significant difference compared to the controls regarding the MPV

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Lipoprotein (a), Lipid Profile and Mean Platelet Volume in Hypothyroid Patients in Sana'a, Yemen: A Case-Control Study

2016

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“…We found there was significant difference between newly diagnosed and patients on lthyroxin treatment (patients still not controlled yet) but numerically there was no evident reduction in MPV and PDW whether Atile NS et al [15] found that a significant decrease in the mean MPV level was detected after the maintenance of euthyroidism with LT4 treatment.…”

Section: Discussionmentioning

confidence: 59%

Hypothyroidism and Platelet Parameter Evaluation

Shehata

El-raouf

Serogy

et al. 2020

JAMMR

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Aims: To evaluate the effect of subclinical and overt hypothyroidism on mean platelet volume (MPV) and platelet distribution width (PDW). Study Design: Cross sectional study. Place and Duration of Study: Outpatient Clinic of Diabetes, Metabolism and Endocrinology Unit in internal medicine department and clinical pathology, Tanta University, Egypt in a period between June 2018 to June 2019. Methodology: We tested 250 subjects; 50 healthy control and 200 hypothyroid patients (all were female; age ≥18 years old age) without any medical history, then patients were subdivided into newly diagnosed group and another group on l-thyroxin treatment. Platelet parameters (MPV, PDW) were assessed in all of them. Results: MPV & PDW is increasing in hypothyroid patients than control group (8.93 ± 0.62), more in overt group (10.88 ± 0.57) than subclinical group (10.02 ± 0.55). No significant reduction in MPV and PDW in patients on l-thyroxin treatment which suggest that l-thyroxin treatment couldn’t produce difference till patients reaching their target level being euthyroid. Conclusion: We recommend the usefulness of MPV and PDW as inexpensive markers of platelet activation in diagnostic work-up of athero-thrombotic complications risk in patients with subclinical and overt hypothyroidism.

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“…Atile et all. 16 raported that PDW values of patients with hypothyroid HT were similar to those of both healthy controls and patients with treated euthyroid HT. However, Bilge et all.…”

Section: Discussionmentioning

confidence: 92%

Hashimoto tiroiditinin trombositler üzerine sayı, büyüklük ve dağılım açısından etkisi

Güvendi¹,

Kara²,

Güvendi³

et al. 2019

Dicle Tıp Dergisi

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Objective: The aim of our study was to investigate whether platelet indices were affected in patients with Hashimoto's thyroiditis (HT). Method: 11 patients (10 female, 1 male) with HT and 26 subjects with nodular goiters (19 female, 7 male) selected as control group were included in the study. All cases were examined for complete blood count parameters (leukocyte count, neutrophil count and percentage, lymphocyte count and percentage, platelet count, plateletcrit, platelet distribution width (PDW), and mean platelet volume (MPV)). Results: Leukocyte count, neutrophil count and percentage, lymphocyte percentage, platelet count, plateletcrit, and MPV in the patient group were not statistically different from the control group. Lymphocyte count and PDW were significantly higher in patients with HT than in the control group. Conclusion: Our results suggest that patients with HT have higher PDW levels. Increased PDW in HT may be helpful in diagnosis, floow-up, and prognosis of the disease.

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Mean platelet volume levels in patients with overt hypothyroidism before and after levothyroxine treatment

Cited by 8 publications

References 0 publications

Lipoprotein (a), Lipid Profile and Mean Platelet Volume in Hypothyroid Patients in Sana'a, Yemen: A Case-Control Study

Lipoprotein (a), Lipid Profile and Mean Platelet Volume in Hypothyroid Patients in Sana'a, Yemen: A Case-Control Study

Hypothyroidism and Platelet Parameter Evaluation

Hashimoto tiroiditinin trombositler üzerine sayı, büyüklük ve dağılım açısından etkisi

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