Mean Platelet Volume May Represent a Predictive Parameter for Overall Vascular Mortality and Ischemic Heart Disease

Abstract

Objective— An increased mean platelet volume (MPV), as an indicator of larger, more reactive platelets resulting from an increased platelet turnover, may represent a risk factor for overall vascular mortality, including myocardial infarction. We intended to identify patients at higher risk of dying from vascular disease in a large, hospital-based cohort. Methods and Results— A total of 206 554 first-ever admissions to the Allgemeines Krankenhaus Wien for determination of MPV between January 1996 and July 2003 were included. Primary end points were overall vascular mortality and death due to ischemic heart disease. Multivariate Cox regression adjusted for sex, age, and platelet count was applied for analysis. MPV values were categorized into quintiles, with the lowest quintile serving as the reference category. Compared with individuals with lower MPV (<8.7 fL), hazard ratios for overall vascular mortality gradually increased to 1.5 in the highest category (≥11.01 fL). The relationship of MPV to ischemic heart disease was even stronger and increased from 1.2 (8.71 to 9.60 fL category) to 1.8 in the highest category (≥11.01 fL). Conclusion— Our results indicate that patients with an increased MPV (≥11.01 fL) are at higher risk of death due to ischemic heart disease, with hazard ratios comparable to those reported for obesity or smoking.

Mean platelet volume and its prognostic value in acute coronary syndrome complicated by cardiogenic shock

“…MPV is considered a useful prognostic marker of cardiovascular risk [2,4,5]. In general population, higher MPV value is associated with increased occurrence of myocardial infarction (MI) [2].…”

Mean platelet volume level in patients with generalized anxiety disorder

“…Increased MPV levels are thought to be closely related to cardiovascular disorders [13]. MPV values were studied in also schizophrenia, bipolar disorder and panic disorder with contradictory and inconclusive results [14][15][16][17][18].…”

Some hematological parameters of Wistar rats treated with Chromolaena odorata leave extracts

“…Larger platelets are more adhesive and tend to aggregate more than small platelets and contain more secretary granules. 25 …”