Mean Platelet Volume (MPV) may Simply Predict the Severity of Sepsis in Preterm Infants

Çatal, Ferhat; Tayman, Cüneyt; Tonbul, Alparslan; Akça, Halise; Kara, Sadık; Tatlı, Mustafa Mansur; Öztekin, Osman; Bilici, Meki

doi:10.7754/clin.lab.2013.130501

Cited by 73 publications

(80 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lower platelet counts and higher MPV levels have been reported in septic patients than in controls [1][2][3][4]. And, it has been reported that MPV levels didn't increase in non-invasive local infection or sepsis with negative blood culture [2].…”

Section: Mpv and Sepsismentioning

confidence: 98%

“…In addition to changes in platelet counts during infections, platelet sizes can be altered by some factors such as platelet formation from megakaryocytes in response to thrombocytopenia or the release of platelet granules due to the activation of platelets [1][2][3][4].…”

mentioning

confidence: 99%

“…Aside from their function in haemostasis, platelets have also a crurical role in the inflammatory response, and also their counts may change in parallel with the severity of infections [1][2][3][4][5][6][7][8][9][10][11]. In addition to changes in platelet counts during infections, platelet sizes can be altered by some factors such as platelet formation from megakaryocytes in response to thrombocytopenia or the release of platelet granules due to the activation of platelets [1][2][3][4].…”

mentioning

confidence: 99%

“…myocardial infarction, ischemic stroke, mesenteric ischemia, deep vein trombosis, decompansated heart failure) or infectious diseases [e.g. sepsis, infective endocarditis, pneumonia, brucellosis, cellulitis, acute pyelonephritis (APN), ascites fluid infection (AFI), hepatitis B or hepatitis C] [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16].…”

mentioning

confidence: 99%

See 3 more Smart Citations

Could mean platelet volume be a useful marker for infectious diseases? a review of literature

Afyon¹,

Artuk²

2016

Med-Science

View full text Add to dashboard Cite

Mean platelet volume (MPV), a parameter of complete blood count analysis, measures the average size of platelets. The alterations of MPV levels have been described as a diagnostic or prognostic predictor in patients with infectious diseases including sepsis, infective endocarditis, pneumonia, brucellosis, cellulitis, acute pyelonephritis, ascites fluid infection, hepatitis B or hepatitis C in recent studies. Although some matters still remain unclear, it can be said that MPV, especially in a scoring system, may be a cost-effective and useful marker for monitoring and predicting outcomes in patients with some infectious diseases in the future.

show abstract

Section: Mpv and Sepsismentioning

confidence: 98%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Could mean platelet volume be a useful marker for infectious diseases? a review of literature

Afyon¹,

Artuk²

2016

Med-Science

View full text Add to dashboard Cite

show abstract

“…Catal et al reported that MPV can be used both at diagnosis and follow-up of sepsis, and at the response of treatment [5]. The authors should also consider these issues in the comparison of MPV measurements.…”

Section: Dear Editormentioning

confidence: 99%

Mean platelet volume in retinopathy of prematurity

Şahin

Uluca

Türkçü

2015

Graefes Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

C-reactive protein for diagnosing late-onset infection in newborn infants

Brown

Meader

Cleminson

et al. 2019

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

Background Late-onset infection is the most common serious complication associated with hospital care for newborn infants. Because confirming the diagnosis by microbiological culture typically takes 24 to 48 hours, the serum level of the inflammatory marker C-reactive protein (CRP) measured as part of the initial investigation is used as an adjunctive rapid test to guide management in infants with suspected late-onset infection. Objectives To determine the diagnostic accuracy of serum CRP measurement in detecting late-onset infection in newborn infants. Search methods We searched electronic databases (MEDLINE, Embase, and Science Citation Index to September 2017), conference proceedings, previous reviews, and the reference lists of retrieved articles. Selection criteria We included cohort and cross-sectional studies evaluating the diagnostic accuracy of serum CRP levels for the detection of late-onset infection (occurring more than 72 hours after birth) in newborn infants. Data collection and analysis Two review authors independently assessed eligibility for inclusion, evaluated the methodological quality of included studies, and extracted data to estimate diagnostic accuracy using hierarchical summary receiver operating characteristic (SROC) models. We assessed heterogeneity by examining variability of study estimates and overlap of the 95% confidence interval (CI) in forest plots of sensitivity and specificity. Main results The search identified 20 studies (1615 infants). Most were small, single-centre, prospective cohort studies conducted in neonatal units in high-or middle-income countries since the late 1990s. Risk of bias in the included studies was generally low with independent assessment of index and reference tests. Most studies used a prespecified serum CRP threshold level as the definition of a 'positive' index test (typical cutoff level between 5 mg/L and 10 mg/L) and the culture of a pathogenic microorganism from blood as the reference standard.

show abstract

Mean Platelet Volume (MPV) may Simply Predict the Severity of Sepsis in Preterm Infants

Cited by 73 publications

References 18 publications

Could mean platelet volume be a useful marker for infectious diseases? a review of literature

Could mean platelet volume be a useful marker for infectious diseases? a review of literature

Mean platelet volume in retinopathy of prematurity

C-reactive protein for diagnosing late-onset infection in newborn infants

Contact Info

Product

Resources

About