Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Platelet Count and Plateletcrit (PCT) as predictors of in-hospital paediatric mortality: a case-control Study

Abstract

Background: Thrombocytopenia has been shown to predict mortality. We hypothesize that platelet indices may be more useful prognostic indicators. Our study subjects were children one month to 14 years old admitted to our hospital. Aim: To determine whether platelet count, plateletcrit (PCT), mean platelet volume (MPV) and platelet distribution width (PDW) and their ratios can predict mortality in hospitalised children. Methods: Children who died during hospital stay were the cases. Controls were age matched children admitted contemporaneously. The first blood sample after admission was used for analysis. Receiver operating characteristic (ROC) curve was used to identify the best threshold for measured variables and the ratios studied. Multiple regression analysis was done to identify independent predictors of mortality. Results: Forty cases and forty controls were studied. Platelet count, PCT and the ratios of MPV/Platelet count, MPV/PCT, PDW/Platelet count, PDW/PCT and MPV x PDW/Platelet count x PCT were significantly different among children who survived compared to those who died. On multiple regression analysis the ratio of MPV/PCT, PDW/Platelet count and MPV/ Platelet count were risk factors for mortality with an odds ratio of 4.31(95% CI, 1.69-10.99), 3.86 (95% CI, 1.53-9.75), 3.45 (95% CI, 1.38-8.64) respectively. In 67% of the patients who died MPV/PCT ratio was above 41.8 and PDW/Platelet count was above 3.86. In 65% of patients who died MPV/Platelet count was above 3.45. Conclusion:The MPV/PCT, PDW/Platelet count and MPV/Platelet count, in the first sample after admission in this case control study were predictors of mortality and could predict 65% to 67% of deaths accurately.

Platelet indices evaluation in patients with dengue fever

“…33 Similarly, the ratios of the platelet indices and platelet index have been compared in a case control study in a pediatric population as a predictor of mortality. 34 None of the other studies in dengue infection have taken into account these ratios. Further prospective studies are needed to assess the utility of these indices in dengue fever.…”

Using Platelet Parameters to Anticipate Morbidity and Mortality Among Preterm Neonates: A Retrospective Study

“…High mean platelet volume (MPV) values are associated with coronary flow and high risks of recurrent stroke in adults (4,5). Elevated MPV, platelet distribution width (PDW), and increased plateletcrit (PCT) are associated with mortality in diseases such as ischemic coronary artery disease, pneumonia, kidney disease, and cancer (6)(7)(8)(9). Platelet activation and consumption are seen commonly in critical ill patients and indicate a poorer prognosis (10).…”

A Potantiel Marker of in-Stentrestenosis: PDW/Platelet Ratio

“…İki ayrı çalışmada artmış PDW /platelet oranının yoğun bakım hastalarında hastalığın ciddiyetiyle doğru orantılı olduğu ve artmış mortaliteyi öngördüğü gösterilmiştir. Bu hasta grubunda belirledikleri cut-off değer 0.07 için duyarlılık ve özgüllük %77 olarak bulunmuştur [16,17].…”

“…Bu ilişkiden yola çıkarak iki parametrenin kombine edilip tek basit bir oran şeklinde hesaplanması altta yatan platelet aktivasyonunu daha iyi yansıtabilir. Buna istinaden son zamanlarda PDW/plateletoranı yeni bir prognostik gösterge olarak kullanılmaya başlanmıştır [16,17]. Yaptığımız literatür taramasına göre daha önce bu oranın perkütan koroner işlemler sonrası sonlanımlara etkisini araştıran çalışma bulunmamaktadır.…”