Mean SOFA Score in Comparison With APACHE II Score in Predicting Mortality in Surgical Patients With Sepsis

Abstract

Background: Sepsis is a medical and surgical emergency that describes the body's systemic immunological response to an infectious process that can lead to end-stage organ dysfunction and death. Various clinical and biochemical parameters serve as indicators of organ dysfunction in patients with sepsis. Most familiar among them are the Sequential Organ Failure Assessment (SOFA) score, Acute Physiology and Chronic Health Evaluation (APACHE) II score, Mortality Prediction Score (MPM), and Simplified Acute Physiology Score (SAPS).Methodology: A comparative study of APACHE II and SOFA scores was done at the time of admission in a total of 72 patients with sepsis and compared with the mean SOFA score. In our study, the SOFA score was measured serially and the mean SOFA score was calculated. All patients were selected according to the definition of sepsis (Sepsis-3). The ROC curve, the sensitivity, and the specificity were calculated to analyze the diagnostic value of SOFA, APACHE II, and the mean SOFA score. For all statistical tests, a "p-value" less than 0.05 was taken to indicate a significant difference.Results: Our study showed that the mean SOFA score had a sensitivity of 93.65 and a specificity of 100, and on comparing the AUC of mean SOFA with APACHE II (Day 1) and SOFA (Day 1) -we got the P-value 0.0066 and 0.0008, which shows a statistically significant difference. So, we can say that the mean SOFA score is better than D 1 (day 1 of admission) APACHE II & SOFA scores in predicting mortality in surgical patients with sepsis.Conclusions: APACHE II and SOFA scores are equally effective in assessing mortality in surgical patients with sepsis at the time of admission. However, if we take serial measurements of SOFA scores and calculate the mean SOFA score it becomes a very useful tool for predicting mortality.

Relationship between serum Midkine and Omentin-1 levels and the severity of sepsis in patients and their prognostic value

“…Midkine levels were measured using an ELISA kit (Catalog#: CSB-E08892h, Wuhan Epitope Biotechnology Co., Ltd.), the intra-assay coefficient of variation is 5.84%, the inter-assay coefficient of variation is 5.41%, and the detection range is 0.1 to 100 ng/mL;Omentin-1 levels were measured using an ELISA kit (Catalog#: XY2457A, Shanghai XuanYa Biotechnology Co., Ltd.), The intra-assay coefficient of variation is 5.91%, the inter-assay coefficient of variation is 5.77%, and the detection range is 10 to 1000 ng/mL. The severity of sepsis patients within 24 hours of admission was assessed using the APACHE II scoring system [ 10 ].…”

Early Prediction of Mortality for Septic Patients Visiting Emergency Room Based on Explainable Machine Learning: A Real-World Multicenter Study

“…Currently, sequential organ failure assessment (SOFA) component scores are used in clinical risk stratification of patients with sepsis; however, they have limitations of poor specificity and sensitivity. 7 8 9 10 11 The SOFA score is one of the main criteria for sepsis-3 definitions. Several previous studies have suggested predictive results for patients with sepsis using the SOFA score; however, they have achieved varying performances in predicting short-term mortality.…”