Meaningful improvement thresholds in measures of pain and quality of life in oral lichen planus

Abstract

Objectives To evaluate the responsiveness of measures of pain and oral health‐related quality of life (OH‐QoL) in patients with oral lichen planus (OLP) and to determine thresholds for minimal important change (MIC) and minimal important difference (MID) for use in this patient population. Methods Data from baseline and 4‐month follow‐up including Visual Analog Scale (VAS), Numerical Rating Scale (NRS), 14‐item Oral Health Impact Profile (OHIP‐14), 15‐item and 26‐item Chronic Oral Mucosal Disease Questionnaire (COMDQ‐15; COMDQ‐26) were collected from 157 patients with OLP. Responsiveness was assessed by testing hypotheses and calculating the area under the curve. MIC and MID were established based on triangulation of distribution‐based and anchor‐based estimates. Results The results supported adequate responsiveness of VAS, NRS, COMDQ‐15 and COMDQ‐26 for use in OLP, while the OHIP‐14 demonstrated relatively low sensitivity to detect improvement in the OLP status. Recommended meaningful improvement thresholds were as follows: VAS (MIC 16 mm; MID 18 mm), NRS (MIC/MID 2 points), OHIP‐14 (MIC/MID 5 points), COMDQ‐15 (MIC 5 points; MID 6 points) and COMDQ‐26 (MIC/MID 9 points). Conclusion This study provides some evidence of responsiveness as well as establishing meaningful improvement thresholds in scores of pain and OH‐QoL measures in OLP.

Impact of Oral Lichen Planus on Oral Health-Related Quality of Life: A Systematic Review and Meta-Analysis

“…We screened 704 potentially relevant, non-duplicate articles ( articles were excluded based on an initial screening of study title tional screening after obtaining the full texts of the articles was car which resulted in the exclusion of additional 31 articles due to the gibility criteria for inclusion. After data collection, additional 5 s resulting in 17 articles [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] being deemed eligible for inclusion studies, 14 articles reported the overall OH-QoL score as a mean a The OHIP-14 score for two studies were obtained from the autho trapolated from median/range values for four studies. Total participants with OLP were 1265 (pooled mean sample s 44, range 10-300), with pooled mean age of 56 years (pooled SD; 6 centages of males and females in the sample were 35.73% (452) and tively.…”

“…However, it is difficult for clinicians and patients to notice a definitive change or improvement in OH-QoL after interventions. Wiriyakijjia et al suggested a threshold for minimal important changes in QoL score [25]. The OHIP-14 scores for OLP patients in the included studies were variable.…”

Psychological profile and unexpected pain in oral lichen planus: A case–control multicenter SIPMO studya

“…; 2012). Painful lesions may affect eating, swallowing, and speaking, causing an impaired quality of life in OLP patients (Wiriyakijja et al., 2020a,b,c). Moreover, other complex oral symptoms, probably related to changes in the surface of the oral mucosa, have been reported (Adamo et.…”

The patient acceptable symptom state in oral lichen planus: identification of cut-off threshold scores in measures of pain and quality of life

“…In this case, conversion of continuous scores into a dichotomous variable using cutoff scores may be of interest [5]. A recent study defined clinical meanings of pain and OH-QoL change scores using the cut-off scores for meaningful change thresholds in patients with OLP [6]. However, the concept of meaningful change thresholds applies for longitudinal data only and clinically meaningful single scores of pain and OH-QoL have yet to be explored in this population.…”