Measured (and estimated) glomerular filtration rate: reference values in West Africa

Yayo, Eric; Ayé, Mireille; Yao, Carine; Gnionsahé, Appolinaire; Attoungbré, M.-L.; Cavalier, Étienne; Pottel, Hans; Monnet, Dagui; Delanaye, Pierre

doi:10.1093/ndt/gfx244

Cited by 25 publications

(33 citation statements)

References 24 publications

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“…This observation confirmed limited previous data suggesting that SCr normal values were comparable in Africa and Europe. 17,31 Regarding reference values, we also confirmed that healthy people from West Africa or Central Africa have the same distribution of mGFR as Whites, 17,18 notably with the same decrease in mGFR with aging. 32 Among the different SCr-based equations, both CKD-EPI and FAS-SCr equations had the same performance in the whole population and in subjects with GFR >60 ml/min per 1.73 m 2 .…”

Section: Discussionsupporting

confidence: 78%

“…21 Previous data from Africa (and African European) also suggested that such an ethnic factor was not valuable. [18][19][20][21][22]29,30 Regarding ethnicity, we showed that FAS SCr af had the same global performance as FAS SCr observed in Whites, both in patients with low GFR values and in subjects with high GFR values. This is easily explained, as Q af was not different from the Q values observed in Whites.…”

Section: Discussionsupporting

confidence: 53%

“…Figure 2 demonstrates that percentiles of normal GFR in healthy African subjects matched with those in Whites, both in Ivory Coast and in the Democratic Republic of Congo (DRC). 18,26…”

Section: Percentiles Of Normal Mgfrmentioning

confidence: 99%

“…Also, relatively few studies have considered the performance of the CKD-EPI and MDRD equations in African people, and most were focused on healthy adult black Africans and/or in one country. [18][19][20] In the present analysis, we evaluated the performance of different equations (Table 1) for GFR estimation in a large cohort of sub-Saharan African people from 2 countries, including patients with CKD. Our goal was to study 3 topics of clinical interest for nephrologists in Africa regarding estimating GFR.…”

mentioning

confidence: 99%

“…The MDRD and CKD-EPI equations were thus considered and compared with and without the African American ethnic factors (ef) (MDRD ef or MDRD and CKD-EPI ef or CKD-EPI). 18,19,21,22 In the same view, specific Q values for African people were proposed for the creatinine-based FAS equation. The creatinine-based FAS equation was considered with these Q values (FAS af) or with the values for Whites (FAS).…”

mentioning

confidence: 99%

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Performance of creatinine- or cystatin C–based equations to estimate glomerular filtration rate in sub-Saharan African populations

Bukabau

Yayo

Gnionsahé

et al. 2019

Kidney International

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Glomerular filtration rate (GFR) is the best index for kidney function; however, the applicability of GFR estimating equations in sub-Saharan African populations remains unclear. In a cross-sectional study of adults living in Kinshasa, Democratic Republic of Congo (n[210) and Abidjan, Ivory Coast (n[284), we evaluated the performance of creatinine and cystatin C-based equations using plasma clearance of iohexol as the reference standard. The race coefficient did not improve the performance of creatinine-based GFR estimates; in fact, both the Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology (CKD-EPI) equations performed better without the race coefficient in participants with GFR ‡60 mL/min/1.73m 2. The CKD-EPI and Full Age Spectrum (FAS) equations were unbiased and had similar precision (SD of 17.9 versus 19 mL/min/1.73 m 2) and accuracy within 30% (P30, 86.7% versus 87.4%) in participants with GFR ‡60 mL/min/1.73m 2. Both equations performed poorly in the subgroup with measured GFR < 60 mL/min/1.73m 2 (n[80), but the FAS equation had smaller bias (L4.8 mL/min/1.73m 2 versus L7.7 mL/min/1.73m 2 for CKD-EPI) and higher P30 (56.3% versus 31.3% for CKD-EPI). The corresponding equations including cystatin C alone or in combination with creatinine had similar performance. In a sub-Saharan African population, adjustment for race did not improve the performance of GFR estimating equations. The creatinine-based FAS and CKD-EPI equations performed reasonably well and were comparable when GFR was ‡ 60 mL/min/1.73m 2. Cystatin C did not improve performance. The FAS equation may be preferable when GFR is < 60 mL/min/1.73m 2 , but this should be confirmed in larger studies.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionsupporting

confidence: 53%

“…Figure 2 demonstrates that percentiles of normal GFR in healthy African subjects matched with those in Whites, both in Ivory Coast and in the Democratic Republic of Congo (DRC). 18,26…”

Section: Percentiles Of Normal Mgfrmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Performance of creatinine- or cystatin C–based equations to estimate glomerular filtration rate in sub-Saharan African populations

Bukabau

Yayo

Gnionsahé

et al. 2019

Kidney International

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Diagnostic Performance of Creatinine-Based Equations for Estimating Glomerular Filtration Rate in Adults 65 Years and Older

et al. 2019

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IMPORTANCE Estimating glomerular filtration rate (GFR) is useful in many clinical conditions. However, very few studies have evaluated the performance of GFR-estimating equations in older adults at various degrees of kidney impairment. OBJECTIVE To determine the performance of plasma-creatinine-based equations Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI), Lund-Malmö Revised, (LMR), full age spectrum (FAS), and Berlin Initiative Study (BIS) 1 in older adults across a broad spectrum of GFRs. DESIGN, SETTING, AND PARTICIPANTS Single-center cross-sectional study performed in France including 2247 participants aged 65 to 90 years who underwent inulin GFR measurements from July 1, 2003, to July 30, 2017, for suspected or established renal dysfunction, for renal risk, before kidney donation, or after kidney transplant. MAIN OUTCOMES AND MEASURES The main outcome measure was GRF measured by inulin clearance. Equation performance criteria considered bias (difference between estimated and measured GFR), precision (interquartile range of the median difference), and accuracy P 30 (percentage of estimated GFRs lying between [measured GFR-30% of measured GFR] and [measured GFR + 30% of measured GFR]). RESULTS The mean (SD) age of the 2247 participants was 71.5 (5) years and 1192 (53.0%) were male. The difference in median (95% CI) bias was significant between CKD-EPI vs LMR (−4.0 [-4.0 to-3.5 mL/min/1.73 m 2 ; P < .001]) and CKD-EPI vs FAS (-2.0 [-3.5 to-2.5] mL/min/1.73 m 2 , P < .001) but not significant between CKD-EPI vs BIS 1 (0.0 [-1.5 to 0.5], P = .07, Mood test). In patients aged 65 to 74 years with measured GFR<45 mL/min/1.73 m 2 , the difference in median P 30 (95% CI) was not significant between CKD-EPI vs LMR (P = .08) and CKD-EPI vs FAS (P = .48) but significant vs BIS 1 (P = .004, McNemar test). In subjects 75 years and older, with measured GFR less than 45 mL/min/1.73 m 2 , LMR and BIS 1 were more accurate than CKD-EPI and FAS (P 30 = 74.

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Impact of estimation versus direct measurement of predonation glomerular filtration rate on the eligibility of potential living kidney donors

Gaillard

Courbebaisse

Kamar

et al. 2019

Kidney International

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Measured (and estimated) glomerular filtration rate: reference values in West Africa

Abstract: Normal GFR values and descriptions of percentiles are now available for West Africa. As in Caucasians, no significant difference was observed between men and women. Moreover, the same age-associated decline in mGFR is also observed after 40 years of age, as in Caucasians.

Cited by 25 publications

References 24 publications

Performance of creatinine- or cystatin C–based equations to estimate glomerular filtration rate in sub-Saharan African populations

Performance of creatinine- or cystatin C–based equations to estimate glomerular filtration rate in sub-Saharan African populations

Diagnostic Performance of Creatinine-Based Equations for Estimating Glomerular Filtration Rate in Adults 65 Years and Older

Impact of estimation versus direct measurement of predonation glomerular filtration rate on the eligibility of potential living kidney donors

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