Measurement and Computational Experiments Within Newborn's Brain Cooling Process

Bandoła, Dominika; Nowak, Andrzej J.; Ostrowski, Ziemowit; Rojczyk, Marek; Walas, Wojciech

doi:10.1615/ihtc16.bma.022900

Cited by 4 publications

(4 citation statements)

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“…The central volume temperature denoted by core in Figure 4(a) and 4(b) is the same for both front and back sectors. The initial fast cooling period of the treatment was simulated by linearly reducing the temperature of the arterial blood from 37°C to 34°C in 1 h (Bandola et al , 2018). The arterial blood temperature was then maintained at 34°C afterwards.…”

Section: Resultsmentioning

confidence: 99%

“…In Wang and Zhu (2007) and Yin et al (2019), both head and neck were modeled. Three-dimensional whole-body models were presented by Łaszczyk et al (2014), Łaszczyk and Nowak (2016), Silva et al (2016) and Bandola et al (2018), some of them with realistic geometries obtained from magnetic resonance imaging. Regarding the cooling technique and device, local brain cooling promoted by surrounding the head with cold water or ice in a cap were considered by Diao and Zhu (2001), Diao et al (2003), Janssen et al (2005), Łaszczyk et al (2014), Łaszczyk and Nowak (2016), Silva et al (2016), Bandola et al (2018), Yin et al (2019) and Nunes et al (2019).…”

Section: Introductionmentioning

confidence: 99%

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An inverse analysis of the brain cooling process in neonates using the particle filter method

Nunes

Orlande

Nowak

2022

HFF

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Purpose This study deals with the computational simulation and inverse analysis of the cooling treatment of the hypoxic-ischemic encephalopathy in neonates. A reduced-order model is implemented for real-time monitoring of the internal body temperatures. The purpose of this study is to sequentially estimate the transient temperatures of the brain and other body regions with reduced uncertainties. Design/methodology/approach Pennes’ model was applied in each body element, and Fiala’s blood pool concept was used for the solution of the forward bioheat transfer problem. A state estimation problem was solved with the Sampling Importance Resampling (SIR) algorithm of the particle filter method. Findings The particle filter method was stable and accurate for the estimation of the internal body temperatures, even in situations involving large modeling and measurement uncertainties. Research limitations/implications The proposed reduced-order model was verified with the results of a high-fidelity model available in the literature. Validation of the proposed model and of the solution of the state estimation problem shall be pursued in the future. Practical implications The solution of the state estimation problem with the reduced-order model presented in this paper has great potential to perform as an observer of the brain temperature of neonates, for the analysis and control of the systemic cooling treatment of neonatal hypoxic-ischemic encephalopathy. Social implications The main treatment for hypoxic-ischemic encephalopathy in neonates is the cooling of affected regions. Accurate and fast models might allow the development of individualized protocols, as well as control strategies for the cooling treatment. Originality/value This paper presents the application of the SIR algorithm for the solution of a state problem during the systemic cooling of a neonate for the treatment of the hypoxic-ischemic encephalopathy.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An inverse analysis of the brain cooling process in neonates using the particle filter method

Nunes

Orlande

Nowak

2022

HFF

Self Cite

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“…By processing these heat transfer rates and applying the energy balance for a neonate, one is capable of determining not only the metabolic heat rate but also changes in this quantity during the therapy. The theoretical basis for the use of non-invasive thermal measurements performed during standard therapeutic hypothermia is discussed for instance in [2], [3] and [4]. The current work is an extension of the paper [4] and its main aim is a novel way of formulating a whole series of energy balances.…”

Section: Introductionmentioning

confidence: 99%

“…The theoretical basis for the use of non-invasive thermal measurements performed during standard therapeutic hypothermia is discussed for instance in [2], [3] and [4]. The current work is an extension of the paper [4] and its main aim is a novel way of formulating a whole series of energy balances. Namely, considering the actual time step its energy effects are added to the energy balance covering the whole period from the beginning of the therapy up to the beginning of the considered time step.…”

Section: Introductionmentioning

confidence: 99%

Non-invasive thermal measurements during newborn’s therapeutic hypothermia and processing of their results

Tumidajski,

Wagstyl,

Bandoła

et al. 2024

J. Phys.: Conf. Ser.

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This paper focuses on the heat transfer processes occurring during the treatment of neonates suffering from hypoxic-ischemic. This is a type of brain dysfunction (brain injury) that happens (mainly during delivery) when the brain experiences a decrease in blood flow (because of abnormal blood circulation) and in consequence, a decrease in oxygen. It frequently results in an increase in brain temperature to the danger level and hypoxia in some other organs. Treatment requires a specialized cooling device to decrease the temperature of the neonate’s body and particularly the brain temperature. One of the cooling methods is so-called “selective brain cooling”, which consists of direct cooling of the head by a cooling cap. In this work results of non-invasive measurements for 11 patients suffering from hypoxic-ischemic encephalopathy and treated at the University Clinical Hospital in Opole, Poland. Collected data were processed in a novel way to formulate a whole series of cumulative energy balances for all patients. It is found that cumulative balancing allows one to determine the metabolic heat rate and results in a more stable history of the therapy than balancing step by step.

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Heat and mass transfer of preterm neonates nursed inside incubators - A review

Hannouch

Lemenand

Khoury

et al. 2020

Thermal Science and Engineering Progress

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Measurement and Computational Experiments Within Newborn's Brain Cooling Process

Cited by 4 publications

References 0 publications

An inverse analysis of the brain cooling process in neonates using the particle filter method

An inverse analysis of the brain cooling process in neonates using the particle filter method

Non-invasive thermal measurements during newborn’s therapeutic hypothermia and processing of their results

Heat and mass transfer of preterm neonates nursed inside incubators - A review

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