Measurement of novel adipokine visfatin in young patients with acute myocardial infarction. Clinical testing of a new ELISA

Stejskal, David; Šigutová, Radka; Švesták, Marek; Václavík, J.; Kušnierová, Pavlína; Švagera, Zdeněk

doi:10.5507/bp.2020.024

Cited by 5 publications

(3 citation statements)

References 4 publications

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“…Studies have shown that visfatin induces Hep G2 cells to produce pro-inflammatory cytokines through the STAT3 and nuclear factor-κB (NF-κB) pathways and inhibits the insulin signaling pathway [7] . Elevated blood visfatin levels in patients with T2DM or metabolic syndrome are related to coronary and carotid atherosclerosis [8] . Some researchers also believe that serum visfatin levels in T2DM patients were significantly elevated, especially in T2DM GG genotype patients with cardiovascular disease (CVD) [9] .…”

Section: Discussionmentioning

confidence: 99%

Research on the Correlation Between rs2110385 Polymorphisms of the Visfatin Gene and Nonproliferative Diabetic Retinopathy

Zhang,

Li,

et al. 2024

JCNR

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Objective: To investigate the association between rs2110385 polymorphisms of the visfatin gene and the risk of type 2 diabetic retinopathy (DR). Methods: 172 Han subjects were selected from Xi’an Shaanxi Province；140 patients with type 2 diabetes mellitus (T2DM) and 32 normal controls (NC) were selected from our hospital. Patients with diabetes were divided into a non-DR group (T2DM) (n = 69) and a nonproliferative diabetic retinopathy Group (DR) (n =71) after dilated fundus photography and fundus fluorescein angiography. rs2110385/Alu Ⅰ genotypes were detected by standardized polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and the differences in the detection rates of different genotypes in the above populations were compared. Results: 1) The visfatin level in the DR Group was significantly higher than that in the NC and T2DM groups (P < 0.05). 2) The frequency of GG genotype and G allele of rs2110385 in the DR Group were higher than those in the T2DM and NC groups (80.3, 69.6, 50.0, 86.6, 79, 65.6, P < 0.05). 3) There were significant differences in allele frequency and genotype frequency distribution of rs2110385 between the DR Group and the NC group (P < 0.01). Conclusion: Visfatin increased in the nonproliferative diabetic retinopathy group and could be a potential indicator for the clinical prediction of DR. The G allele of the rs2110385 polymorphic site may be related to the risk of DR.

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Section: Discussionmentioning

confidence: 99%

Research on the Correlation Between rs2110385 Polymorphisms of the Visfatin Gene and Nonproliferative Diabetic Retinopathy

Zhang,

Li,

et al. 2024

JCNR

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“…Zheng et al found a strong relationship between increased visfatin levels (>8.799 ng/mL) and major adverse cardiovascular events (MACEs) in acute myocardial infarction [26]. Stejskal et al reported that the 20 ng/ mL cut-off value of visfatin is an independent marker for AMI with high sensitivity (84%) and specificity (90%) [27]. Miranda-Filloy et al found visfatin levels higher in AS patients than healthy controls, but they did not find any relationship between visfatin level with lipid parameters and BASDAI [28].…”

Section: Discussionmentioning

confidence: 99%

The relationship of serum visfatin levels with clinical parameters, flow-mediated dilation, and carotid intima-media thickness in patients with ankylosing spondylitis

Baykara¹,

Küçük²,

Tuzcu³

et al. 2021

Turk J Med Sci

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Background/aim: Atherosclerotic heart diseases can occur at an early age in patients with ankylosing spondylitis (AS). Flow-mediated dilation (FMD) and carotid intima-media thickness (cIMT) values are reliable markers for early detection of subclinical atherosclerosis in patients with AS. We aimed to investigate the relationship between visfatin levels and indirect markers of subclinical atherosclerosis and endothelial dysfunction in patients with AS. Materials and methods:Forty-two patients diagnosed with AS and 42 age, sex, and body mass index (BMI)-matched controls were included in the study. Visfatin levels, FMD, and cIMT were measured using appropriate methods.Results: Visfatin levels of the patients were significantly higher than controls (p < 0.001). FMD values in patients with AS were significantly lower (p = 0.007) whereas cIMT were significantly higher than the controls (p = 0.003). There was a negative relationship between FMD with visfatin levels (p = 0.004), BASDAI (p = 0.010), and BASFI (p = 0.007). There was a positive relationship between cIMT with visfatin (p = 0.005), BASDAI (p < 0.001), and BASFI (p < 0.001). There was a positive relationship between visfatin with BASDAI (p < 0.001), and BASFI (p < 0.001). Conclusion:Visfatin levels are increased and associated with impaired FMD and increased cIMT in patients with AS. Increased visfatin levels may be associated with subclinical atherosclerosis in AS.

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“…Terefore, fnding biological markers for efective prediction in the early stage of NSTE-ACS and then taking measures to achieve satisfactory therapeutic efects has always been a hot topic in academic research. In recent years, studies have found that visfatin plays an important role in the occurrence and outcome of ACS [3][4][5]. Tis study intends to observe the diference of serum visfatin levels between NSTE-ACS patients and control group, then to explore the relationship between visfatin and the number of diseased coronary artery.…”

Section: Introductionmentioning

confidence: 99%

Visfatin Related to the Severity of Non-ST-Segment Elevation Acute Coronary Syndrome: A Retrospective Study of 164 Patients at a Tertiary Chest Pain Center

Zheng,

Wu,

Liu

et al. 2024

Journal of Interventional Cardiology

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Acute coronary syndrome (ACS) poses a pervasive threat to individuals grappling with cardiovascular afflictions, manifesting as unstable angina, non-ST-segment elevation myocardial infarction (NSTEMI), ST-segment elevation myocardial infarction (STEMI), or sudden cardiac death, depending on vascular obstruction’s extent and location. NSTEMI, closely linked to substantial morbidity and mortality, has become the primary cause of hospitalization in ischemic heart disease patients. Swift prognostication of non-ST-segment elevation acute coronary syndrome (NSTE-ACS) is crucial, necessitating the identification of precise markers. This study, conducted from January 2020 to March 2021, explored the correlation between serum visfatin levels and NSTE-ACS severity. A total of 164 patients undergoing coronary angiography were enrolled, with a control group (n = 55) exhibiting less than 50% coronary stenosis. NSTE-ACS patients were categorized based on angiography outcomes into single-vessel (n = 41), double-vessel (n = 28), and multivessel (n = 40) groups. Serum visfatin levels, meticulously quantified, showed significant elevation in NSTE-ACS patients (n = 109) compared to the control group (n = 55) (P<0.01). Visfatin correlated positively with the GRACE score (r = 0.397, P<0.01). In the multivessel disease group, visfatin levels were notably higher (P<0.01). After adjusting for cardiovascular risk factors, visfatin emerged as an independent predictor of affected coronary arteries (OR 0.205; 95% CI 0.032–0.378; P=0.02). Receiver-operating characteristic (ROC) curves demonstrated enhanced prognostic ability when combining visfatin with age, hypertension, and diabetes for multivessel disease (AUC: 0.839, sensitivity: 65.0%, specificity: 89.7%, P<0.001). Elevated serum visfatin in NSTE-ACS patients suggests its role as an independent harbinger for the number of affected coronary arteries, potentially indicating severity in NSTE-ACS patients.

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Measurement of novel adipokine visfatin in young patients with acute myocardial infarction. Clinical testing of a new ELISA

Cited by 5 publications

References 4 publications

Research on the Correlation Between rs2110385 Polymorphisms of the Visfatin Gene and Nonproliferative Diabetic Retinopathy

Research on the Correlation Between rs2110385 Polymorphisms of the Visfatin Gene and Nonproliferative Diabetic Retinopathy

The relationship of serum visfatin levels with clinical parameters, flow-mediated dilation, and carotid intima-media thickness in patients with ankylosing spondylitis

Visfatin Related to the Severity of Non-ST-Segment Elevation Acute Coronary Syndrome: A Retrospective Study of 164 Patients at a Tertiary Chest Pain Center

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