Measurement of the hyperelastic properties of 72 normal homogeneous and heterogeneous ex vivo breast tissue samples

Dempsey, Sergio C. H.; O'Hagan, Joseph J; Samani, Abbas

doi:10.1016/j.jmbbm.2021.104794

Cited by 10 publications

(5 citation statements)

References 36 publications

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“…Focusing on the hyperelastic behavior, Samani and Plewes (2004) performed indentation tests and successfully measured the adipose and fibroglandular breast tissue hyperelastic parameters, using an inverse technique based on FE modeling. A similar protocol was used by Dempsey et al (2021) , in which adipose, fibrogladular, and mixed tissues were tested via indentation to estimate the hyperelastic properties using 4 models. They concluded that the three types of tissues were statistically similar, which corroborates the use of a homogeneous model for large strain simulation.…”

Section: Breast Tissue: Basic Concepts and Mechanical Propertiesmentioning

confidence: 99%

A review of bioengineering techniques applied to breast tissue: Mechanical properties, tissue engineering and finite element analysis

Teixeira

Martins

2023

Front. Bioeng. Biotechnol.

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Female breast cancer was the most prevalent cancer worldwide in 2020, according to the Global Cancer Observatory. As a prophylactic measure or as a treatment, mastectomy and lumpectomy are often performed at women. Following these surgeries, women normally do a breast reconstruction to minimize the impact on their physical appearance and, hence, on their mental health, associated with self-image issues. Nowadays, breast reconstruction is based on autologous tissues or implants, which both have disadvantages, such as volume loss over time or capsular contracture, respectively. Tissue engineering and regenerative medicine can bring better solutions and overcome these current limitations. Even though more knowledge needs to be acquired, the combination of biomaterial scaffolds and autologous cells appears to be a promising approach for breast reconstruction. With the growth and improvement of additive manufacturing, three dimensional (3D) printing has been demonstrating a lot of potential to produce complex scaffolds with high resolution. Natural and synthetic materials have been studied in this context and seeded mainly with adipose derived stem cells (ADSCs) since they have a high capability of differentiation. The scaffold must mimic the environment of the extracellular matrix (ECM) of the native tissue, being a structural support for cells to adhere, proliferate and migrate. Hydrogels (e.g., gelatin, alginate, collagen, and fibrin) have been a biomaterial widely studied for this purpose since their matrix resembles the natural ECM of the native tissues. A powerful tool that can be used in parallel with experimental techniques is finite element (FE) modeling, which can aid the measurement of mechanical properties of either breast tissues or scaffolds. FE models may help in the simulation of the whole breast or scaffold under different conditions, predicting what might happen in real life. Therefore, this review gives an overall summary concerning the human breast, specifically its mechanical properties using experimental and FE analysis, and the tissue engineering approaches to regenerate this particular tissue, along with FE models.

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Section: Breast Tissue: Basic Concepts and Mechanical Propertiesmentioning

confidence: 99%

A review of bioengineering techniques applied to breast tissue: Mechanical properties, tissue engineering and finite element analysis

Teixeira

Martins

2023

Front. Bioeng. Biotechnol.

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“…Cardiovascular tissue and skin were the next most commonly studied tissues. The remaining studies focused on tissues from the ear, nose, and throat, 43,56,71,91,100,116,131,210 cornea, 77,129,171 lens, 83 central nervous structures, 39,47,49,65,78,101,105,109,111,113,117,121,122,135,148,156,165,170,215 peripheral nervous structures, 141,145,208 adipose, 48 breast, 66,110,176,179 heel pad, 55,103,110 tissues supporting the abdomen, 108,124 parietal pleura, 184 perineal body, 125 soft tissues near pressure ulcers, 75 lung, 118 liver, 30,50,119,133,134,159,174,194 stomach, 133,134 gallbladder, 92,120 spleen, 174 and prostate 207 . There were 57 studies that did not focus on musculoskeletal, cardiovascular, or skin tissues.…”

Section: Resultsmentioning

confidence: 99%

“…During full-text review, study citations were examined, and 20 articles were identified and included. A total of 186 papers 29–31,33–215 were included for data extraction.…”

Section: Resultsmentioning

confidence: 99%

“…This is probably because the study’s objectives influence which biomechanical measurements are required. For example, constitutive parameters (eg, third-order Ogden hyperelastic parameters, 5-term polynomial hyperelastic parameters) 66 were used to develop mathematical models of a tissue’s response to applied loads. A study in which the main objective was to develop a database of material properties reported on more “traditional” material properties (eg, elastic modulus) 176 …”

Section: Resultsmentioning

confidence: 99%

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Applied use of biomechanical measurements from human tissues for the development of medical skills trainers: a scoping review

Kriener,

Whiting,

Storr

et al. 2023

JBI Evidence Synthesis

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Objective: The objective of this review was to identify quantitative biomechanical measurements of human tissues, the methods for obtaining these measurements, and the primary motivations for conducting biomechanical research. Introduction: Medical skills trainers are a safe and useful tool for clinicians to use when learning or practicing medical procedures. The haptic fidelity of these devices is often poor, which may be because the synthetic materials chosen for these devices do not have the same mechanical properties as human tissues. This review investigates a heterogenous body of literature to identify which biomechanical properties are available for human tissues, the methods for obtaining these values, and the primary motivations behind conducting biomechanical tests. Inclusion criteria: Studies containing quantitative measurements of the biomechanical properties of human tissues were included. Studies that primarily focused on dynamic and fluid mechanical properties were excluded. Additionally, studies only containing animal, in silico, or synthetic materials were excluded from this review. Methods: This scoping review followed the JBI methodology for scoping reviews and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews (PRISMA-ScR). Sources of evidence were extracted from CINAHL (EBSCO), IEEE Xplore, MEDLINE (PubMed), Scopus, and engineering conference proceedings. The search was limited to the English language. Two independent reviewers screened titles and abstracts as well as full-text reviews. Any conflicts that arose during screening and full-text review were mediated by a third reviewer. Data extraction was conducted by 2 independent reviewers and discrepancies were mediated through discussion. The results are presented in tabular, figure, and narrative formats. Results: Data were extracted from a total of 186 full-text publications. All of the studies, except for 1, were experimental. Included studies came from 33 different countries, with the majority of the studies coming from the United States. Human tissues samples were ex vivo, and the most commonly studied tissue type was musculoskeletal. In this study, nearly 200 unique biomechanical values were reported, and the most commonly reported value was Young’s (elastic) modulus. The most common type of mechanical test performed was tensile testing, and the most common reason for testing human tissues was to characterize biomechanical properties. Although the number of published studies on biomechanical properties of human tissues has increased over the past 20 years, there are many gaps in the literature. Of the 186 included studies, only 7 used human tissues for the design or validation of medical skills training devices. Furthermore, in studies where biomechanical values for human tissues have been obtained, a lack of standardization in engineering assumptions, methodologies, and tissue preparation may implicate the usefulness of these values. Conclusions: This review is the first of its kind to give a broad overview of the biomechanics of human tissues in the published literature. With respect to high-fidelity haptics, there is a large gap in the published literature. Even in instances where biomechanical values are available, comparing or using these values is difficult. This is likely due to the lack of standardization in engineering assumptions, testing methodology, and reporting of the results. It is recommended that journals and/or experts in engineering fields conduct further research to investigate the feasibility of implementing reporting standards. Review Registration: Open Science Framework osf.io/fgb34

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“…Taking advantage of the fact that malignant tumors tend to be stiffer than normal tissue and benign lesions, ultrasound elastography (USE) techniques have been developed as a cost-effective imaging technique to visualize tissue stiffness. While cost-effective, this technique can be used for preliminary assessment of malignancy [2][3][4][5], hence potentially minimizing the number of follow-up biopsies. Typically, USE is performed through tissue mechanical stimulation, measuring the generated displacement field, and finally using this field to compute the tissue stiffness image.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Ultrasound Tissue Motion Tracking Techniques for Effective Breast Ultrasound Elastography

Caius,

Samani

2023

Applied Sciences

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Breast cancer is the most common and deadly cancer in women, where early detection is of the utmost importance as survival rates decrease with the advancement of the disease. Most available methods of breast cancer screening and evaluation lack the ability to effectively differentiate between benign and malignant lesions without a biopsy. Ultrasound elastography (USE) is a cost-effective method that can potentially provide an initial malignancy assessment at the bedside. One of the challenges, however, is the uncertainty of tissue displacement data when performing USE due to out-of-plane movement of the tissue during mechanical stimulation, in addition to the computational efficiency necessary for real-time image reconstruction. This work presents a comparison of four different theoretically sound displacement estimators for their ability in tissue Young’s modulus reconstruction level with an emphasis on quality-to-runtime ratio to determine which estimators are most suitable for real-time USE systems. The methods are known in literature as AM2D, GLUE, OVERWIND, and SOUL methods. The effectiveness of each method was assessed as a stand-alone method or in combination with a strain field enhancement technique known as STREAL, which was recently developed using tissue mechanics-based regularization. The study was performed using radiofrequency US data pertaining to in silico and tissue mimicking phantoms in addition to clinical data. This data was used to generate tissue displacement fields employed to generate axial and lateral strain images before Young’s modulus images were reconstructed. The study indicates that the AM2D displacement estimator, which is an older and computationally less involved method, along with a tissue-mechanics-based image processing algorithm, performs very well, with high CNR, SNR, and preservation of tumor heterogeneity obtained at both strain and stiffness image levels, while its computation run-time is much lower compared to other estimation methods. As such, it can be recommended for incorporation in real-time USE systems.

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Measurement of the hyperelastic properties of 72 normal homogeneous and heterogeneous ex vivo breast tissue samples

Cited by 10 publications

References 36 publications

A review of bioengineering techniques applied to breast tissue: Mechanical properties, tissue engineering and finite element analysis

A review of bioengineering techniques applied to breast tissue: Mechanical properties, tissue engineering and finite element analysis

Applied use of biomechanical measurements from human tissues for the development of medical skills trainers: a scoping review

Comparative Study of Ultrasound Tissue Motion Tracking Techniques for Effective Breast Ultrasound Elastography

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