Measurement of theophylline absorption from different regions of the gastro-intestinal tract using a remote controlled durg delivery device

Abstract

The absorption of a theophylline solution containing 80-120 mg doses delivered to different sites in the gastro-intestinal tract has been determined in 3 male volunteers using a remote controlled drug release system (HF-capsule). There was no difference between the stomach, ileum and the colon in the amount of theophylline absorbed (AUC). The T 1/2abs of theophylline absorbed via the colon was prolonged when compared with that entering via the upper gastro-intestinal tract. The results provide a rational basis for the further development of theophylline formulations and are indispensable for planned development and to account for variation in the bioavailability of retarded release drug preparations.

Examining Small Intestinal Transit Time as a Function of Age: Is There Evidence to Support Age-Dependent Differences among Children?

“…As a result, pediatric oral absorption models are commonly parameterized in a similar manner to those of adults. Second, theophylline is considered to be Biopharmaceutics Classification System class I compound (high solubility and high permeability) with adequate levels of absorption attainable throughout the entire GI tract (i.e., small bowel and colon) (Staib et al, 1986). When formulated as a SR preparation, the limiting factor modulating theophylline absorption can be attributed to its rate of release.…”

Pharmacokinetics of Lisdexamfetamine Dimesylate after Targeted Gastrointestinal Release or Oral Administration in Healthy Adults

“…Traditionally, in vitro dissolution tests followed by conventional pharmacokinetic studies, coupled with intubation and fluoroscopy methods, have been performed (Staib et al, 1986;Shargel et al, 2005). Although designed to assess drug absorption, these methods are not useful in establishing drug-release mechanisms (Davis et al, 1992).…”

“…The intubation tubes have an impact on GI motility (Read et al, 1983). A less invasive and more pharmaceutically relevant technique is the use of remote-controlled drug-release systems, which include the high-frequency capsule (Battelle-Institute V, Frankfurt am Main, Germany) (Staib et al, 1986;Harder et al, 1990), InteliSite capsule (Casper Associates, Raleigh, NC), and Enterion capsule (Phaeton Research, Nottingham, UK) (Prior et al, 2004). Gamma scintigraphy (a well established radionuclide imaging technique) provides information on regional drug absorption and is a useful tool to evaluate various drug-delivery methods (Davis et al, 1992;Meseguer et al, 1994).…”

Development of colon targeted multiparticulate pulsatile drug delivery system for treating nocturnal asthma

“…TP was used as a model drug due to its suitable pharmacokinetic properties for colonic delivery and good absorption in the large intestine (Staib et al, 1986;Paola et al, 2003).…”