The objective of the research is to study the biology of the pathogen of the scab Venturia pirina Aderh depending on the agrometeorological conditions of the pear vegetation and to assess the collection cultivars for susceptibility to the disease. The biological features of the pear scab in the western foothill agro-climatic region of the Crimea are studied. The influence of climatic conditions on the occurrence of various epidemiological types of scab manifestations on pears is estimated. As a result of the research, highly resistant cultivars were found: Zhukovka, Zaporozhskaya, Triumph of Jodoin, Vodyanistaya, Dorodnaya, Bere Shibasso, Martin Sekl, which showed moderate levels of infection spread in all years of research, with the development of the disease in the range of 0.2-1.3%. Immune cultivars of pears with absolute resistance to the pathogen agent V. pirina, which was not affected by changes in weather conditions, were identified. These cultivars are the following: Zimovka, Trapezitsa, Chervona, Shara Bera, Seyanets Kolossa, Populyarnaya, Kurzemskaya Maslyanaya, Wonderful Italy, which can be used in breeding and ecologized protection systems when supplying with cuttings horticultural industries in the Crimea and the south of Russia.