Measuring acute pulmonary responses to occupational wildland fire smoke exposure using exhaled breath condensate

Wu, Chao-Hsin; Adetona, Anna M.; Song, Chi; Naeher, Luke P.; Adetona, Olorunfemi

doi:10.1080/19338244.2018.1562413

Cited by 25 publications

(13 citation statements)

References 25 publications

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“…In a study of fire-fighters by Wu et al, there was a marginal increase of 8-isoprostane levels in the post-shift EBC samples on burn days (3.5-3.8 pg/mL; p = 0.06) compared to non-burn days (2.86-3.20 pg/mL) [29]. These post-shift levels were approximately 10-fold lower than the concentrations in this study's worker subjects post-shift, as a less sensitive method, the enzyme-linked immunosorbent assays (ELISA), was used in that study.…”

Section: Acute Effectmentioning

confidence: 90%

Three-Year Study of Markers of Oxidative Stress in Exhaled Breath Condensate in Workers Producing Nanocomposites, Extended by Plasma and Urine Analysis in Last Two Years

et al. 2020

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Human data concerning exposure to nanoparticles are very limited, and biomarkers for monitoring exposure are urgently needed. In a follow-up of a 2016 study in a nanocomposites plant, in which only exhaled breath condensate (EBC) was examined, eight markers of oxidative stress were analyzed in three bodily fluids, i.e., EBC, plasma and urine, in both pre-shift and post-shift samples in 2017 and 2018. Aerosol exposures were monitored. Mass concentration in 2017 was 0.351 mg/m3 during machining, and 0.179 and 0.217 mg/m3 during machining and welding, respectively, in 2018. In number concentrations, nanoparticles formed 96%, 90% and 59%, respectively. In both years, pre-shift elevations of 50.0% in EBC, 37.5% in plasma and 6.25% in urine biomarkers were observed. Post-shift elevation reached 62.5% in EBC, 68.8% in plasma and 18.8% in urine samples. The same trend was observed in all biological fluids. Individual factors were responsible for the elevation of control subjects’ afternoon vs. morning markers in 2018; all were significantly lower compared to those of workers. Malondialdehyde levels were always acutely shifted, and 8-hydroxy-2-deoxyguanosine levels best showed chronic exposure effect. EBC and plasma analysis appear to be the ideal fluids for bio-monitoring of oxidative stress arising from engineered nanomaterials. Potential late effects need to be targeted and prevented, as there is a similarity of EBC findings in patients with silicosis and asbestosis.

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Section: Acute Effectmentioning

confidence: 90%

Three-Year Study of Markers of Oxidative Stress in Exhaled Breath Condensate in Workers Producing Nanocomposites, Extended by Plasma and Urine Analysis in Last Two Years

et al. 2020

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“…43,44 For the respiratory case study, electrostatic stationary dust samplers will be employed to collect dust samples in the participants’ home during one week and will be analyzed for microbial abundance and diversity using a microbiome approach. 45,46…”

Section: Project Descriptionmentioning

confidence: 99%

Applying the exposome concept to working life health

Pronk

Loh

Kuijpers

et al. 2022

Environmental Epidemiology

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The EPHOR Consortium, Rob Stierum a loskeletal disorders. 4 Conservative estimates of the global burden of occupational disease vary between 3% and 7% of global mortality, translating to 1.5 to 2.3 million deaths each year. [5][6][7] In the European Union (EU), approximately 300,000 work-related deaths per year are estimated resulting in economic losses of Abstract. Exposures at work have a major impact on noncommunicable diseases (NCDs). Current risk reduction policies and strategies are informed by existing scientific evidence, which is limited due to the challenges of studying the complex relationship between exposure at work and outside work and health. We define the working life exposome as all occupational and related nonoccupational exposures. The latter includes nonoccupational exposures that may be directly or indirectly influenced by or interact with the working life of the individual in their relation to health. The Exposome Project for Health and Occupational Research aims to advance knowledge on the complex working life exposures in relation to disease beyond the single high exposure-single health outcome paradigm, mapping and relating interrelated exposures to inherent biological pathways, key body functions, and health. This will be achieved by combining (1) large-scale harmonization and pooling of existing European cohorts systematically looking at multiple exposures and diseases, with (2) the collection of new high-resolution external and internal exposure data. Methods and tools to characterize the working life exposome will be developed and applied, including sensors, wearables, a harmonized job exposure matrix (EuroJEM), noninvasive biomonitoring, omics, data mining, and (bio)statistics. The toolbox of developed methods and knowledge will be made available to policy makers, occupational health practitioners, and scientists. Advanced knowledge on working life exposures in relation to NCDs will serve as a basis for evidence-based and cost-effective preventive policies and actions. The toolbox will also enable future scientists to further expand the working life exposome knowledge base.

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“…WFS has been associated with impacts on respiratory disorders including asthma, bronchitis, dyspnea, and COPD, cardiovascular disease, and mortality [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. Limited evidence shows that the level of systemic inflammation markers, such as interleukin-8 (IL-8) and C-reactive protein (CRP), are also associated with WFS [ 11 , 12 ]. Separately, there is growing evidence that social status may increase susceptibility to pollution [ 13 , 14 ], possibly mediated via chronic stress and associated ‘allostatic load’ pathways [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Social status and susceptibility to wildfire smoke among outdoor-housed female rhesus monkeys: A natural experiment

Bai

Capitanio

Miller

et al. 2021

Heliyon

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Measuring acute pulmonary responses to occupational wildland fire smoke exposure using exhaled breath condensate

Cited by 25 publications

References 25 publications

Three-Year Study of Markers of Oxidative Stress in Exhaled Breath Condensate in Workers Producing Nanocomposites, Extended by Plasma and Urine Analysis in Last Two Years

Three-Year Study of Markers of Oxidative Stress in Exhaled Breath Condensate in Workers Producing Nanocomposites, Extended by Plasma and Urine Analysis in Last Two Years

Applying the exposome concept to working life health

Social status and susceptibility to wildfire smoke among outdoor-housed female rhesus monkeys: A natural experiment

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