Measuring and tracking vitamin B12: A review of current methods with a focus on optical spectroscopy

Tsiminis, Georgios; Schartner, Erik P.; Brooks, Joanna; Hutchinson, Mark R.

doi:10.1080/05704928.2016.1229325

Cited by 28 publications

(32 citation statements)

References 119 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Optical spectroscopy techniques, including chemiluminescence, absorption, fluorescence, and Raman spectroscopy, have been demonstrated to be powerful methods for the detection and quantification of VitB12 in food matrices and human tissues such as blood, serum, and urine [ 100 ]. Nanotechnologies offer unique solutions to improve the sensitivity of these methods by taking advantage of the enhancement of the electromagnetic signal in presence of metal nanoparticles or surfaces with nanosized features due to the surface plasmon resonance (SPR) effect.…”

Section: Nanotechnologies and Vitb12mentioning

confidence: 99%

Current Nanocarrier Strategies Improve Vitamin B12 Pharmacokinetics, Ameliorate Patients’ Lives, and Reduce Costs

et al. 2021

View full text Add to dashboard Cite

Vitamin B12 (VitB12) is a naturally occurring compound produced by microorganisms and an essential nutrient for humans. Several papers highlight the role of VitB12 deficiency in bone and heart health, depression, memory performance, fertility, embryo development, and cancer, while VitB12 treatment is crucial for survival in inborn errors of VitB12 metabolism. VitB12 is administrated through intramuscular injection, thus impacting the patients’ lifestyle, although it is known that oral administration may meet the specific requirement even in the case of malabsorption. Furthermore, the high-dose injection of VitB12 does not ensure a constant dosage, while the oral route allows only 1.2% of the vitamin to be absorbed in human beings. Nanocarriers are promising nanotechnology that can enable therapies to be improved, reducing side effects. Today, nanocarrier strategies applied at VitB12 delivery are at the initial phase and aim to simplify administration, reduce costs, improve pharmacokinetics, and ameliorate the quality of patients’ lives. The safety of nanotechnologies is still under investigation and few treatments involving nanocarriers have been approved, so far. Here, we highlight the role of VitB12 in human metabolism and diseases, and the issues linked to its molecule properties, and discuss how nanocarriers can improve the therapy and supplementation of the vitamin and reduce possible side effects and limits.

show abstract

Section: Nanotechnologies and Vitb12mentioning

confidence: 99%

Current Nanocarrier Strategies Improve Vitamin B12 Pharmacokinetics, Ameliorate Patients’ Lives, and Reduce Costs

et al. 2021

View full text Add to dashboard Cite

show abstract

“…There is a potential causal association between these highly prevalent mental symptoms and low serum levels of B vitamins [ 11 ]. Pyridoxine (vitamin B6), folic acid (vitamin B9), and cobalamin (vitamin B12) are necessary cofactors for the synthesis of myelin and neurotransmitters [ 12 , 13 , 14 , 15 , 16 , 17 ]. A decrease in levels of these vitamins is associated with elevated homocysteine levels, risk of cognitive impairment [ 18 , 19 , 20 , 21 , 22 , 23 ], and depression [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression

et al. 2021

View full text Add to dashboard Cite

Vitamin B12 is often used to improve cognitive function, depressive symptoms, and fatigue. In most cases, such complaints are not associated with overt vitamin B12 deficiency or advanced neurological disorders and the effectiveness of vitamin B12 supplementation in such cases is uncertain. The aim of this systematic review and meta-analysis of randomized controlled trials (RCTs) is to assess the effects of vitamin B12 alone (B12 alone), in addition to vitamin B12 and folic acid with or without vitamin B6 (B complex) on cognitive function, depressive symptoms, and idiopathic fatigue in patients without advanced neurological disorders or overt vitamin B12 deficiency. Medline, Embase, PsycInfo, Cochrane Library, and Scopus were searched. A total of 16 RCTs with 6276 participants were included. Regarding cognitive function outcomes, we found no evidence for an effect of B12 alone or B complex supplementation on any subdomain of cognitive function outcomes. Further, meta-regression showed no significant associations of treatment effects with any of the potential predictors. We also found no overall effect of vitamin supplementation on measures of depression. Further, only one study reported effects on idiopathic fatigue, and therefore, no analysis was possible. Vitamin B12 supplementation is likely ineffective for improving cognitive function and depressive symptoms in patients without advanced neurological disorders.

show abstract

“…Estimation of Vitamin B12 was done by the chemiluminescent microparticle intrinsic factor assay for the quantitative determination of Vitamin B12 in human serum method. [ 12 ]…”

Section: Inclusion Criteriamentioning

confidence: 99%

Evaluation of Hematological profile in Oral Submucous Fibrosis: A Cross-sectional Study

Patil

Joshi

2020

J Oral Maxillofac Pathol

View full text Add to dashboard Cite

Measuring and tracking vitamin B12: A review of current methods with a focus on optical spectroscopy

Cited by 28 publications

References 119 publications

Current Nanocarrier Strategies Improve Vitamin B12 Pharmacokinetics, Ameliorate Patients’ Lives, and Reduce Costs

Current Nanocarrier Strategies Improve Vitamin B12 Pharmacokinetics, Ameliorate Patients’ Lives, and Reduce Costs

Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression

Evaluation of Hematological profile in Oral Submucous Fibrosis: A Cross-sectional Study

Contact Info

Product

Resources

About