Measuring Apparent Trabecular Density and Bone Structure Using Peripheral Quantitative Computed Tomography at the Tibia: Precision in Participants With and Without Spinal Cord Injury

Giangregorio, Lora; Lala, Deena; Hummel, Kayla; Gordon, Christopher L.; Craven, B. Catharine

doi:10.1016/j.jocd.2012.02.003

Cited by 10 publications

(8 citation statements)

References 37 publications

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“…We have established pQCT precision in our setting among individuals with and without SCI; the root mean square coefficient of variation was ≤2% for all bone outcomes of interest. 34 Analyses of the pQCT scans were performed using the manufacturer's software (Stratec XCT-2000 version 5.50). Contour mode 3 and peel mode 2 with an outer threshold of 130 mg/cm 3 and an inner threshold of 400 mg/cm 3 was used in CALCBD mode to assess trabecular vBMD (TbvBMD, milligrams per cubic centimeter).…”

Section: Osteocalcinmentioning

confidence: 99%

Evaluating the efficacy of functional electrical stimulation therapy assisted walking after chronic motor incomplete spinal cord injury: effects on bone biomarkers and bone strength

Craven

Giangregorio

Alavinia

et al. 2017

The Journal of Spinal Cord Medicine

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Section: Osteocalcinmentioning

confidence: 99%

Evaluating the efficacy of functional electrical stimulation therapy assisted walking after chronic motor incomplete spinal cord injury: effects on bone biomarkers and bone strength

Craven

Giangregorio

Alavinia

et al. 2017

The Journal of Spinal Cord Medicine

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“…To ensure consistency, the same technologist performed all the scans. We have established precision in our setting in individuals with and without SCI; the root mean square coefficient of variation was ≤2 % for all bone measures of interest [31].…”

Section: Pqct Assessmentmentioning

confidence: 99%

Exploring the determinants of fracture risk among individuals with spinal cord injury

et al. 2013

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“…Several cross-sectional studies confirmed that trabecular architecture is markedly deteriorated after chronic SCI [22]. The only available longitudinal studies described changes of bone stiffness and strength properties over a short-time post-SCI but did not report adaptations of trabecular micro-architectural parameters [2, 23, 24].…”

Section: Introductionmentioning

confidence: 99%

Bone architecture adaptations after spinal cord injury: impact of long-term vibration of a constrained lower limb

et al. 2015

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Summary This study examined the effect of a controlled dose of vibration upon bone density and architecture in people with spinal cord injury (who eventually develop severe osteoporosis). Very sensitive computed tomography (CT) imaging revealed no effect of vibration after 12 months, but other doses of vibration may still be useful to test. Introduction The purposes of this report were to determine the effect of a controlled dose of vibratory mechanical input upon individual trabecular bone regions in people with chronic spinal cord injury (SCI) and to examine the longitudinal bone architecture changes in both the acute and chronic state of SCI. Methods Participants with SCI received unilateral vibration of the constrained lower limb segment while sitting in a wheelchair (0.6g, 30 Hz, 20 min, three times weekly). The opposite limb served as a control. Bone mineral density (BMD) and trabecular micro-architecture were measured with high-resolution multi-detector CT. For comparison, one participant was studied from the acute (0.14 year) to the chronic state (2.7 years). Results Twelve months of vibration training did not yield adaptations of BMD or trabecular micro-architecture for the distal tibia or the distal femur. BMD and trabecular network length continued to decline at several distal femur sub-regions, contrary to previous reports suggesting a “steady state” of bone in chronic SCI. In the participant followed from acute to chronic SCI, BMD and architecture decline varied systematically across different anatomical segments of the tibia and femur. Conclusions This study supports that vibration training, using this study’s dose parameters, is not an effective antiosteoporosis intervention for people with chronic SCI. Using a high-spatial-resolution CT methodology and segmental analysis, we illustrate novel longitudinal changes in bone that occur after spinal cord injury.

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Measuring Apparent Trabecular Density and Bone Structure Using Peripheral Quantitative Computed Tomography at the Tibia: Precision in Participants With and Without Spinal Cord Injury

Cited by 10 publications

References 37 publications

Evaluating the efficacy of functional electrical stimulation therapy assisted walking after chronic motor incomplete spinal cord injury: effects on bone biomarkers and bone strength

Evaluating the efficacy of functional electrical stimulation therapy assisted walking after chronic motor incomplete spinal cord injury: effects on bone biomarkers and bone strength

Exploring the determinants of fracture risk among individuals with spinal cord injury

Bone architecture adaptations after spinal cord injury: impact of long-term vibration of a constrained lower limb

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