Measuring circulating miRNAs in early pregnancy could identify fetuses’ destined to undergrow and be at increased risk of stillbirth

Tong, Stephen; Kaitu’u-Lino, Tu’uhevaha J

doi:10.1016/j.ebiom.2020.103172

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2024

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“…Tong and Kaitu'u-Lino observed that miRs 374a-5p and let-7d-5p, while not necessarily clinical biomarkers, exhibited early derangement by 12-14 weeks gestation in pregnancies leading to preterm birth. This highlights a sensitive first-trimester period, suggesting the origins of fetal growth restriction proposed over 20 years ago [22].…”

Section: Resultsmentioning

confidence: 82%

MicroRNA Associations with Preterm Labor—A Systematic Review

Kondracka,

Stupak,

Rybak-Krzyszkowska

et al. 2024

IJMS

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This systematic review delves into the connections between microRNAs and preterm labor, with a focus on identifying diagnostic and prognostic markers for this crucial pregnancy complication. Covering studies disseminated from 2018 to 2023, the review integrates discoveries from diverse pregnancy-related scenarios, encompassing gestational diabetes, hypertensive disorders and pregnancy loss. Through meticulous search strategies and rigorous quality assessments, 47 relevant studies were incorporated. The synthesis highlights the transformative potential of microRNAs as valuable diagnostic tools, offering promising avenues for early intervention. Notably, specific miRNAs demonstrate robust predictive capabilities. In conclusion, this comprehensive analysis lays the foundation for subsequent research, intervention strategies and improved outcomes in the realm of preterm labor.

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Section: Resultsmentioning

confidence: 82%