Measuring disease activity and response to treatment in rheumatoid arthritis

Buzatu, Casandra; Moots, Robert J.

doi:10.1080/1744666x.2019.1559050

Cited by 16 publications

(10 citation statements)

References 52 publications

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“…However, a major proportion of the patients (44%) still had reduced grip force at 5 years. The results of this study underline the importance of using PROMs in the assessment of patients with RA, which is an important part of modern management .…”

Section: Discussionmentioning

confidence: 72%

The Relation Between Disease Activity, Patient‐Reported Outcomes, and Grip Force Over Time in Early Rheumatoid Arthritis

Rydholm

Wikström

Hagel

et al. 2019

ACR Open Rheumatology

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ObjectiveThe objective of this study is to identify early predictors of future reduced grip force in patients with rheumatoid arthritis (RA) and to identify early predictors of grip force over time.MethodsIn a structured follow‐up of an inception cohort of patients with early RA, average grip force values of the dominant hand were evaluated and compared with the expected based on age‐ and sex‐specific reference values. Potential predictors of reduced grip force (less than 50% of expected) at 5 years were examined using logistic regression. Differences in percentage of expected grip force values over the study period and differences in change over time, by baseline disease parameters, were estimated using mixed linear‐effects models.ResultsAmong 200 patients with early RA, 44% had reduced grip force 5 years after diagnosis. Baseline characteristics that predicted reduced grip force at 5 years included high scores for the Health Assessment Questionnaire Disability Index (odds ratio 1.54 per SD; 95% confidence interval 1.13‐2.11), high scores for pain and patient global assessment, and low grip force. C‐reactive protein levels, the erythrocyte sedimentation rate, the 28‐joint Disease Activity Score (DAS28), rheumatoid factor, anti–cyclic citrullinated peptide antibodies, joint counts, and synovitis of individual joints in the dominant upper extremity did not predict reduced grip force. Patients with baseline synovitis of the wrist or metacarpophalangeal joints or patients with a high DAS28 had lower estimated grip force at inclusion but also greater improvement of grip force over time.ConclusionPatient‐reported outcomes predicted reduced grip strength 5 years after diagnosis. This underlines the prognostic importance of disability in early RA. Joint counts and synovitis in individual joints may change rapidly in early RA and appear to be less predictive of long‐term hand function.

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Section: Discussionmentioning

confidence: 72%

The Relation Between Disease Activity, Patient‐Reported Outcomes, and Grip Force Over Time in Early Rheumatoid Arthritis

Rydholm

Wikström

Hagel

et al. 2019

ACR Open Rheumatology

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“…Although there is no definite information about the pathological processes that cause the emergence of RA, it contains a balance between genetic risks and environmental factors. If the inflammatory process that leads to the formation of RA is left uncontrolled, it will injure the joints and cause disability (2). RA disease can cause consequences such as disability, bone erosion, cartilage damage, morbidity, and mortality.…”

Section: Introductionmentioning

confidence: 99%

A New Inflammation Marker in Rheumatoid Arthritis: Immature Granulocyte

ÖZCAN

GÜLTEN

2023

Kırıkkale Üniversitesi Tıp Fakültesi Dergisi

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Objective: This study aimed to reveal whether immature granulocyte levels can be used for determining the disease activity of rheumatoid arthritis. Material and Methods: The study was conducted in the Kastamonu Rehabilitation Center. The data of 163 patients with rheumatoid arthritis were reviewed retrospectively. Laboratory data of 92 healthy individuals were used for the control group. Complete blood cell counts, measurement of erythrocyte sedimentation rate, and C-reactive protein level were used for the laboratory assessments. The individuals with active infection and any hematological, cardiovascular, metabolic disorder, malignancy, history of trauma, surgery, and hospitalization within the last 15 days were excluded from the study. Results: We found that the number and percentage of immature granulocyte were significantly higher in the patient group (p

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“…Early diagnosis of the underlying inflammation is essential for effective treatment in rheumatoid arthritis. Furthermore, measurement of disease activity is essential to target treatment and improve outcomes (4).…”

Section: Introductionmentioning

confidence: 99%