Measuring Marrow Density and Area Using Peripheral Quantitative Computed Tomography at the Tibia: Precision in Young and Older Adults and Individuals With Spinal Cord Injury

Gibbs, Jenna C.; Brown, Zachary M.; Wong, Andy Kin On; Craven, B. Catharine; Adachi, Jonathan D.; Giangregorio, Lora

doi:10.1016/j.jocd.2017.02.002

Cited by 6 publications

(3 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This measure was used as a means of internal validation against the threshold‐segmented MwD measure from Stratec. Marrow analysis at 66% tibias: Stratec software was used to separate the mid‐tibial cortex from medullary area using contour mode 1, peel mode 2, and outer and inner thresholds of 280 and 100 mg/cm 3 , respectively, as previously validated by Gibbs and colleagues . The mid‐tibial MwD was extracted as the trabecular region density.…”

Section: Methodsmentioning

confidence: 99%

“…Gibbs and colleagues measured diaphyseal BMA from peripheral quantitative computed tomography (pQCT) scans of the mid-leg using a threshold-based segmentation method, yielding reproducible values (precision error 2% to 5%) that were comparable to that obtained by a watershedguided manual segmentation method. (17) However, this study did not examine the 4% tibia where differences in bone metabolism are more apparent. Although Goldstein and colleagues have identified marrow within cortical pore spaces at the distal tibia, (18) the sequence used was neither fat-specific nor quantitative.…”

Section: Introductionmentioning

confidence: 96%

“…Moreover, MRS is less accessible on most clinical MRIs. Gibbs and colleagues measured diaphyseal BMA from peripheral quantitative computed tomography (pQCT) scans of the mid‐leg using a threshold‐based segmentation method, yielding reproducible values (precision error 2% to 5%) that were comparable to that obtained by a watershed‐guided manual segmentation method . However, this study did not examine the 4% tibia where differences in bone metabolism are more apparent.…”

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Bone Marrow and Muscle Fat Infiltration Are Correlated among Postmenopausal Women With Osteoporosis: The AMBERS Cohort Study

Wong

Chandrakumar

Whyte

et al. 2019

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

Bone and muscle have shown to interact, but little is known about fat within bone and muscle. Clinical studies have isolated fat within bone and muscle using MRI. In this cross‐sectional study, we hypothesized that bone marrow adiposity and muscle adiposity are related and that this relationship is associated with osteoporosis. Postmenopausal women aged 60 to 85 years were recruited as part of the Appendicular Muscle and Bone Extension Research Study (AMBERS). Participants completed dual‐energy X‐ray absorptiometry (DXA) of the hip and spine to diagnose osteoporosis. Muscle adiposity was measured with MRI at the 66% site of the leg. Fat segmentation was achieved using a semi‐automated iterative threshold‐optimizing algorithm (error < 5%). Peripheral quantitative computed tomography measured marrow density of the 4% distal tibia (surrogate for marrow fat) by threshold‐based, edge‐detection segmentations and by examining residuals from trabecular bone density regressed on trabecular tissue mineral density. Muscle adiposity from MRI was regressed on marrow density using linear regression. Models were further examined with an interaction with osteoporosis status. Among 312 women (aged 75.4 ± 5.9 years, body mass index [BMI] 29.5 ± 5.7 kg/m2), a larger amount of muscle fat was associated with lower marrow density at the 66% mid‐tibia (B = 84.08 [27.56], p = 0.002) and at the 4% distal tibia (B = 129.17 [55.96], p = 0.022) after accounting for age, height, weight, average daily energy expenditure, hypertension, and diabetes. Interactions of this relationship with osteoporosis status were also significant. Upon probing these interactions, the relationships were significant only in women with osteoporosis but not in those without osteoporosis. Fat from bone marrow and muscle may be related to one another through the same phenomenon, which is likely also responsible for osteoporosis, but independent of hypertension and diabetes. More research should focus on the potential abnormalities in muscle and bone fat metabolism and mesenchymal cell commitment to fat within patients with osteoporosis. © 2019 American Society for Bone and Mineral Research.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation