Measuring multidimensional particle size distributions during crystallization

Schorsch, Stefan; Vetter, Thomas; Mazzotti, Marco

doi:10.1016/j.ces.2011.11.029

Cited by 74 publications

(100 citation statements)

References 26 publications

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“…Intensive research and development has been carried out to obtain 3D topographical data of objects in robotics and machine vision areas for applications such as vehicle identification and face recognition. In addition, research is being carried out for threedimensional (3D) particle shape measurements [1,30,45,48,51,56,65], in particular the determination of crystal facet growth rates.…”

Section: Three-dimensional Imaging Systemsmentioning

confidence: 99%

Measurement, modelling, and closed-loop control of crystal shape distribution: Literature review and future perspectives

2016

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Crystal morphology is known to be of great importance to the end-use properties of the crystal product and affect the down-stream processing such as in filtration and drying, but was previously regarded as too challenging to achieve automatic closed-loop control. As a consequence, previous work has focused on control the crystal size distribution (CSD) where the size of a crystal is often defined as the diameter of a sphere that has the same volume of the crystal. This paper reviews very promising new advances made in recent years in morphological population balance models for modelling and simulation of crystal shape distribution (CShD), measurement and estimation of crystal facet growth kinetics, as well as in 2D and 3D imaging for on-line characterisation of crystal morphology and CShD. A framework is presented integrating various components in order to achieve the ultimate objective of model-based closed-loop control of CShD. The knowledge gaps and challenges that require further research are also identified.

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Section: Three-dimensional Imaging Systemsmentioning

confidence: 99%

Measurement, modelling, and closed-loop control of crystal shape distribution: Literature review and future perspectives

2016

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“…Therefore, for suspension crystallisation processes, stereoscopic imaging, i.e., photographing the same particle from multiple view directions, is a promising method to overcome the issue (Bujak and Bottlinger, 2008;Wang et al, 2008). A method of photographing from vertical directions using a single camera but two mirrors the same particles that flow through a cell was presented by Mazzotti and co-workers (Kempkes et al, 2010;Schorsch et al, 2012). The system was further improved based on their early work, i.e., replacing the mirrors with a second camera (Schorsch et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

On-line measurement of the real size and shape of crystals in stirred tank crystalliser using non-invasive stereo vision imaging

Zhang

Cai

Liu

et al. 2015

Chemical Engineering Science

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Non-invasive stereo vision imaging technique was applied to monitoring a cooling crystallisation process in a stirred tank for real-time characterisation of the size and shape of needle-like Lglutamic acid (LGA)  polymorphic crystals grown from solution. The instrument consists of two cameras arranged in an optimum angle that take 2D images simultaneously and are synchronised with the lighting system. Each 2D image pair is processed and analysed and then used to reconstruct the 3D shape of the crystal. The needle shaped LGA  form crystal length thus obtained is found to be in good agreement with the result obtained from off-line analysis of crystal samples, and is about three times larger than that estimated using 2D imaging technique. The result demonstrates the advantage of 3D imaging over 2D in measurement of crystal real size and shape.

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“…In these industries, accurate control or monitoring of crystal size is eagerly demanded because particle size has significant effects on downstream operations such as filtration, drying, transport and storage [1][2].…”

Section: Introductionmentioning

confidence: 99%

On-line monitoring of the crystallization process: relationship between crystal size and electrical impedance spectra

Zhao

Yao

Wang

2016

Meas. Sci. Technol.

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On-line monitoring of crystal size in the crystallization process is crucial to many pharmaceutical and fine-chemical industrial applications. In this paper, a novel method is proposed for the on-line monitoring of the cooling crystallization process of L-glutamic acid (LGA) using electrical impedance spectroscopy (EIS). The EIS method can be used to monitor the growth of crystal particles relying on the presence of an electrical double layer on the charged particle surface and the polarization of double layer under the excitation of alternating electrical field. The electrical impedance spectra and crystal size were measured on-line simultaneously by an impedance analyzer and focused beam reflectance measurement (FBRM), respectively. The impedance spectra were analyzed using the equivalent circuit model and the equivalent circuit elements in the model can be obtained by fitting the experimental data. Two equivalent circuit elements, including capacitance (C 2 ) and resistance (R 2 ) from the dielectric polarization of the LGA solution and crystal particle/solution interface, are in relation with the crystal size. The mathematical relationship between the crystal size and the equivalent circuit elements can be obtained by a non-linear fitting method. The function can be used to predict the change of crystal size during the crystallization process.

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Measuring multidimensional particle size distributions during crystallization

Cited by 74 publications

References 26 publications

Measurement, modelling, and closed-loop control of crystal shape distribution: Literature review and future perspectives

Measurement, modelling, and closed-loop control of crystal shape distribution: Literature review and future perspectives

On-line measurement of the real size and shape of crystals in stirred tank crystalliser using non-invasive stereo vision imaging

On-line monitoring of the crystallization process: relationship between crystal size and electrical impedance spectra

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