Measuring nasal nitric oxide in allergic rhinitis patients

Nešić, Vladimir; Djordjević, Vesna; Spirić, Vesna Tomić; Dudvarski, Zoran; Soldatović, Ivan; Arsović, Nenad

doi:10.1017/s0022215116009087

Cited by 22 publications

(35 citation statements)

References 27 publications

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“…These data suggest that nasal FENO in combination with clinical symptoms might be a useful tool for diagnosis of AR. Nesic et al also showed that the levels of nasal FENO in AR patients were significantly higher than in healthy individuals and that nasal FENO measurement had an excellent reliability 13. Interestingly, the results of our study showed that in subjects with AR-asthma, bronchial FENO and CANO were significantly higher than in healthy subjects and subjects with AR; however, there were no significant correlations with nasal FENO.…”

Section: Discussionsupporting

confidence: 47%

“…This result is very interesting in regard to the use of nasal FENO as an independent parameter for the diagnosis of rhinosinusitis. The use of nasal FENO in diagnosis of AR has been reported in previous studies 13,17. Similar to other allergic inflammatory airway diseases such as asthma, in AR, the increase in nasal FENO appears to be related to the upregulation of inducible NO synthase, mainly in epithelial cells and eosinophils 19–22…”

Section: Discussionmentioning

confidence: 67%

“…In subjects with AR, nasal FENO is triggered principally by airborne allergens (pollens, house dust mite, insects, or pets) 9,10. Similar to the lower airway, the concentration of nasal FENO can be measured by constant aspiration or expiratory flows by nasal mask 11–13. Studies demonstrated that in healthy subjects and in subjects with AR, the values of nasal FENO are dependent on aspiration and expiratory flow rate.…”

Section: Introductionmentioning

confidence: 99%

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Study of nasal exhaled nitric oxide levels in diagnosis of allergic rhinitis in subjects with and without asthma

Duong‐Quy

Vu-Minh²,

Hua-Huy

et al. 2017

JAA

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Section: Discussionsupporting

confidence: 47%

Section: Discussionmentioning

confidence: 67%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Study of nasal exhaled nitric oxide levels in diagnosis of allergic rhinitis in subjects with and without asthma

Duong‐Quy

Vu-Minh²,

Hua-Huy

et al. 2017

JAA

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“…Eosinophils from the nasal cavity of patients with AR showed elevated production of ROS and an excess of ROS serve an important role in the pathogenesis of airway inflammation . Also, nasal NO levels in patients with AR are significantly higher than those of healthy control subjects , and ozone produced from NO by the action of sunlight reportedly exacerbates the symptoms of AR . Several studies have shown that LLLI regulates allergic lung inflammation via signal transducer and activator of transduction 6 in mouse allergic asthma models and starts the modulation of physiological processes incrementing the production of ATP, which stimulates the microcirculation, increases collagen fiber deposition, promotes higher fibroblast cell proliferation in the site of the lesion, and reduces the number of inflammatory cells .…”

Section: Discussionmentioning

confidence: 99%

Effects of Low‐Level Laser Irradiation in a Mouse Model of Allergic Rhinitis

Bae

Kim

et al. 2019

Lasers Surg Med

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Background and Objectives To evaluate the antiallergic effect of low‐level laser irradiation (LLLI) at 650 nm in a mouse model of allergic rhinitis (AR), and to examine the underlying mechanisms. Study Design/Materials and Methods BALB/c mice were sensitized with ovalbumin (OVA) and alum and challenged intranasally with OVA. Straight‐ and diffusion‐type LLLI were applied directly into the intranasal cavity of the mice once daily for 10 days (650 nm, 5 mW, 15 min/day) and multiple allergic parameters were evaluated. Results LLLI reduced allergic symptoms, such as rubbing and sneezing, and suppressed the serum total immunoglobulin E (IgE), OVA‐specific IgE, and OVA‐specific IgG1 levels. Diffusion‐type LLLI significantly reduced eosinophil infiltration of nasal mucosa and lymph nodes (LNs). LLLI reduced the expression of interleukin‐4 (IL‐4) and IL‐17 in cervical LN and splenocyte culture supernatant, as well as their messenger RNA levels in nasal mucosa. However, the expression of interferonγ (IFN‐γ) and IL‐6 was unaffected by LLLI. The levels of reactive oxygen species (ROS) and nitric oxide (NO) in LN cells and the nasal mucosa, which were increased in the AR group, were reduced by LLLI, suggesting involvement of ROS and NO within their mechanism. Conclusions LLLI exerted an antiallergic effect by decreasing local and systemic IL‐4, IL‐17, and IgE levels, as well as eosinophilic infiltration into the nasal mucosa, in a mouse model of AR by modulating ROS and NO levels. Diffusion‐type LLLI exhibited greater efficacy against AR than straight‐type LLLI. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.

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“…In this issue, a paper by Nesic et al found higher average oral and nasal nitric oxide levels in acute rhinitis patients (without concomitant asthma) compared with healthy subjects. 6 The authors further demonstrate the reliability and applicability of the measurement of nasal nitric oxide levels by both aspiration and exhalation methods. In keeping with the 'one airway' hypothesis, the results suggest generalised airway inflammation, even in the absence of asthma.…”

mentioning

confidence: 82%