The integration of sustainable entrepreneurship education in higher education is important as part of efforts to step towards equipping future leaders with the knowledge, skills and mindset needed to address global sustainability challenges through innovative and entrepreneurial solutions. This approach involves a multidisciplinary, holistic education model that combines the principles of sustainability with entrepreneurial practices. This paper, which entails a case studies approach, examines the current initiatives being undertaken by a sample of higher education institutions located in Asia, Africa, North America, South America and Europe, with the aim of fostering sustainable entrepreneurship. It concludes by proposing a series of measures with respect to sustainable entrepreneurship that higher education institutions may deploy, to address the environmental, social, and economic dimensions of the global sustainability challenges.