Measuring Total Blood Calcium Displays a Low Sensitivity for the Diagnosis of Hypercalcemia in Incident Renal Transplant Recipients

Evenepoel, Pieter; Bammens, Bert; Claes, Kathleen; Meijers, Björn; Vanrenterghem, Yves

doi:10.2215/cjn.02460310

Cited by 26 publications

(16 citation statements)

References 48 publications

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“…Generally hypocalcaemia has not been considered to be a frequent phenomenon in HIV infection and used to be mostly attributed to hypoalbuminaemia or to pharmacotherapy like foscarnet or ketoconazole [35-38]. In spite of this, the current study revealed high prevalence of hypocalcaemia in HIV infected participants (74.3%) than their negative counterparts (44%).…”

Section: Discussioncontrasting

confidence: 67%

“…Commercially available single element standard solutions (1000 mg/ml) were purchased from Wako Pure Chemicals (Osaka, Japan) and used for standardization of calibration curves. To allow for protein binding of calcium, measured serum total calcium concentrations were corrected for hypoalbuminemia using the following equation as published by [ 35 ]: Corrected Ca = serum Ca + 0.8 (4 - serum albumin).…”

Section: Methodsmentioning

confidence: 99%

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HIV associated hypocalcaemia among diarrheic patients in northwest Ethiopia: a cross sectional study

et al. 2014

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BackgroundHypocalcaemia, defined by serum calcium level less than 8.5 mg/dl, could be caused by human immunodeficiency virus (HIV) and diarrheal diseases. In Ethiopia, while morbidities from diarrheal diseases and HIV are serious health problems, studies assessing the interactions amongst of the three do not exist. Therefore, the present study was undertaken to investigate the level of calcium among diarrheic patients with and without HIV co-infection.MethodsConsecutive diarrheic patients attending Gondar University Hospital in Ethiopia were enrolled and screened for HIV, intestinal parasites, Shigella and Salmonella. Concentration of calcium in serum was determined using an inductively coupled plasma mass spectrometer.ResultsA total of 206 diarrheic patients were included in the study (109 = HIV positive, 97 = HIV negative). Intestinal parasites and Shigella species were detected in 32.2% and 8.5% of the patients, respectively. The serum calcium levels in the patients who were found positive for Shigella species or intestinal parasites was not significantly different by the presence or absence of HIV co-infection. HIV infected diarrheic patients had significantly lower mean serum calcium levels (7.82 ± 1.23 mg/dl) than those negative for HIV (8.38 ± 1.97) (P = 0.015). The age groups 25–35 and greater than 45 years showed significantly lower mean serum calcium levels (7.77 ± 1.55 mg/dl) in comparison to the other age groups (7.84 ± 1.41 mg/dl, P = 0.009). On the other hand, females presented with significantly lower mean serum calcium levels (7.79 ± 1.60 mg/dl, P = 0.044) than males (8.26 ± 1.65 mg/dl).ConclusionThere is high prevalence of hypocalcaemia among diarrheic patients in northwest Ethiopia. And HIV stood out to be a major risk factor for development of hypocalcaemia among the diarrheic patients in northwest Ethiopia. Further studies are required to substantiate and characterize the mechanisms and consequences of calcium metabolism disorders among HIV infected individuals in the study area.

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Section: Discussioncontrasting

confidence: 67%

Section: Methodsmentioning

confidence: 99%

HIV associated hypocalcaemia among diarrheic patients in northwest Ethiopia: a cross sectional study

et al. 2014

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“…In general, persistent HPT prevails in the early post-transplant period while de novo SHPT will become more prominent as kidney transplant function declines. While persistent HPT by definition is maladaptive and may contribute to specific post-transplant complications such as hypercalcaemia [106], hypophosphataemia [107, 108], (cortical) bone loss [109], fractures [110, 111] and nephrocalcinosis [112], de novo SHPT may be appropriate to the declining transplant function. Consequently, patients with a (predominant) persistent HPT phenotype may be hypothesized to benefit most from PTH suppressive therapy.…”

Section: Persistent Hyperparathyroidism After Renal Transplantationmentioning

confidence: 99%

Novel insights into parathyroid hormone: report of The Parathyroid Day in Chronic Kidney Disease

Ureña-Torres

Vervloet²,

Mazzaferro

et al. 2018

Clinical Kidney Journal

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Chronic kidney disease (CKD) is often associated with a mineral and bone disorder globally described as CKD-Mineral and Bone Disease (MBD), including renal osteodystrophy, the latter ranging from high bone turnover, as in case of secondary hyperparathyroidism (SHPT), to low bone turnover. The present article summarizes the important subjects that were covered during ‘The Parathyroid Day in Chronic Kidney Disease’ CME course organized in Paris in September 2017. It includes the latest insights on parathyroid gland growth, parathyroid hormone (PTH) synthesis, secretion and regulation by the calcium-sensing receptor, vitamin D receptor and fibroblast growth factor 23 (FGF23)–Klotho axis, as well as on parathyroid glands imaging. The skeletal action of PTH in early CKD stages to the steadily increasing activation of the often downregulated PTH receptor type 1 has been critically reviewed, emphasizing that therapeutic strategies to decrease PTH levels at these stages might not be recommended. The effects of PTH on the central nervous system, in particular cognitive functions, and on the cardiovascular system are revised, and the reliability and exchangeability of second- and third-generation PTH immunoassays discussed. The article also reviews the different circulating biomarkers used for the diagnosis and monitoring of CKD-MBD, including PTH and alkaline phosphatases isoforms. Moreover, it presents an update on the control of SHPT by vitamin D compounds, old and new calcimimetics, and parathyroidectomy. Finally, it covers the latest insights on the persistence and de novo occurrence of SHPT in renal transplant recipients.

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“…Najbardziej wiarygodnym badaniem dia gnostycznym jest oznaczenie stężenia wapnia zjoni zowanego. Uważa się je za zwiększone, gdy prze kracza 1,29 mmol/l [66]. W regulacji stężenia wapnia w organizmie biorą udział kalcytonina, kalcytriol, parathormon, tyreotropina, wolna trójjodotyronina.…”

Section: Wapńunclassified

Vitamin supplementation in oncological patients. Part II – vitamin C, fat-soluble vitamins and the elements calcium and iron

Badian¹,

Dzierżanowski²

2018

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Measuring Total Blood Calcium Displays a Low Sensitivity for the Diagnosis of Hypercalcemia in Incident Renal Transplant Recipients

Cited by 26 publications

References 48 publications

HIV associated hypocalcaemia among diarrheic patients in northwest Ethiopia: a cross sectional study

HIV associated hypocalcaemia among diarrheic patients in northwest Ethiopia: a cross sectional study

Novel insights into parathyroid hormone: report of The Parathyroid Day in Chronic Kidney Disease

Vitamin supplementation in oncological patients. Part II – vitamin C, fat-soluble vitamins and the elements calcium and iron

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