Mechanical and Histopathological Comparison between Commercialized and Newly Designed Coronary Bare Metal Stents in a Porcine Coronary Restenosis Model

Lim, Kyung Seob; Bae, In Ho; Kim, Jung Ha; Park, Dae Sung; Kim, Jong Min; Kim, Jung Hyun; Sim, Doo Sun; Hong, Young Joon; Jeong, Myung Ho

doi:10.4068/cmj.2013.49.1.7

Cited by 16 publications

(9 citation statements)

References 27 publications

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“…4b). Previously, we have been reported the superiority of CNUH stent (0.46 ± 0.079 N) on flexibility [21,22]. It was speculated that the mechanical properties of PCS is similar to CNUH since the peptide was coated to CNUH stent.…”

Section: Discussionmentioning

confidence: 94%

“…Previously, we have reported that the own designed bare metal stent (BMS, designated as CNUH stent) [21,22] . It showed the great performance on flexibility, biocompatibility and moderate performance under the guide line of FDA in foreshortening and recoil performance.…”

Section: Preparation Of Bare Metal Stentmentioning

confidence: 99%

“…These similarities have led to some concern over the longterm effect of DES following complete elution of the drug [20]. That is the reason why, previously, we have reported that our own stent design (designated as CNUH stent) to prepare the backbone for the development of DES [21,22]. It was greatly superior to other commercialized stent in terms of stent flexibility.…”

Section: Introductionmentioning

confidence: 99%

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Mechanical and physio-biological properties of peptide-coated stent for re-endothelialization

et al. 2020

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Background: The aim of this study was to characterize the mechanical and physio-biological properties of peptidecoated stent (PCS) compared to commercialized drug-eluting stents (DESs). Methods: WKYMVm (Trp-Lys-Tyr-Met-Val-D-Met), a stimulating peptide for homing endothelial colony-forming cell was specially synthesized and coated to bare metal stent (BMS) by dopamine-derived coordinated bond. Biological effects of PCS were investigated by endothelial cell proliferation assay and pre-clinical animal study. And mechanical properties were examined by various experiment. Results: The peptide was well-coated to BMS and was maintained and delivered to 21 and 7 days in vitro and in vivo, respectively. Moreover, the proliferation of endothelial cell in PCS group was increased (approximately 36.4 ± 5.77%) in PCS group at 7 day of culture compare to BMS. Although, the radial force of PCS was moderated among study group. The flexibility of PCS was (0.49 ± 0.082 N) was greatest among study group. PCS did not show the outstanding performance in recoil and foreshortening test (3.1 ± 0.22% and 2.1 ± 0.06%, respectively), which was the reasonable result under the guide line of FDA (less than 7.0%). The nominal pressure (3.0 mm in a diameter) of PCS established by compliance analysis was 9 atm. The changing of PCS diameter by expansion was similar to other DESs, which is less than 10 atm of pressure for the nominal pressure. Conclusions: These results suggest that the PCS is not inferior to commercialized DES. In addition, since the PCS was fabricated as polymer-free process, secondary coating with polymer-based immunosuppressive drugs such as-limus derivatives may possible.

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Section: Discussionmentioning

confidence: 94%

Section: Preparation Of Bare Metal Stentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mechanical and physio-biological properties of peptide-coated stent for re-endothelialization

et al. 2020

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“…The BMS (CNUH stent) used in the study was fabricated by laser-cut processing in a cobalt chromium alloy tube (L605 Co-Cr alloy) and electropolished to a strut thickness of \70 lm [14,15]. An ultrasonic spray method was used to apply coatings to the prepared BMS (3 9 16 mm).…”

Section: Preparation Of Aes Ses and Sasmentioning

confidence: 99%

Effect of stents coated with a combination of sirolimus and alpha-lipoic acid in a porcine coronary restenosis model

Lim

Park

Jeong

et al. 2016

J Mater Sci: Mater Med

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The aim of this study was to evaluate antiproliferative sirolimus- and antioxidative alpha-lipoic acid (ALA)-eluting stents using biodegradable polymer [poly-L-lactic acid (PLA)] in a porcine coronary overstretch restenosis model. Forty coronary arteries of 20 pigs were randomized into four groups in which the coronary arteries had a bare metal stent (BMS, n = 10), ALA-eluting stent with PLA (AES, n = 10), sirolimus-eluting stent with PLA (SES, n = 10), or sirolimus- and ALA-eluting stent with PLA (SAS, n = 10). A histopathological analysis was performed 28 days after the stenting. The ALA and sirolimus released slowly over 30 days. There were no significant differences between groups in the injury or inflammation score; however, there were significant differences in the percent area of stenosis (56.2 ± 11.78% in BMS vs. 51.5 ± 12.20% in AES vs. 34.7 ± 7.23% in SES vs. 28.7 ± 7.30% in SAS, P < 0.0001) and fibrin score [1.0 (range 1.0-1.0) in BMS vs. 1.0 (range 1.0-1.0) in AES vs. 2.0 (range 2.0-2.0) in SES vs. 2.0 (range 2.0-2.0) in SAS, P < 0.0001] between the four groups. The percent area of stenosis based on micro-computed tomography corresponded with the restenosis rates based on histopathological stenosis in different proportions in the four groups (54.8 ± 7.88% in BMS vs. 50.4 ± 14.87% in AES vs. 34.5 ± 7.22% in SES vs. 28.9 ± 7.22% in SAS, P < 0.05). SAS showed a better neointimal inhibitory effect than BMS, AES, and SES at 1 month after stenting in a porcine coronary restenosis model. Therefore, SAS with PLA can be a useful drug combination for coronary stent coating to suppress neointimal hyperplasia.

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“…In a previous study, our novel Co-Cr alloy BMS (CNUH stent) showed non-inferior histopathological effects compared to a commercial BMS. 9 PLA was purchased from EVONIK (UK) and sirolimus was purchased LC Laboratories (USA). An ultrasonic spray method was used to apply the coatings to the prepared BMS (3 × 16 mm).…”

Section: Preparation Of Pla-based Sirolimus Coating On a Novel Bare-mmentioning

confidence: 99%

Biodegradable Polymer-Based Sirolimus Coating Stent in a Porcine Coronary Restenosis Model

Lim

Park

Jeong

et al. 2014

Clin Exp Thromb Hemost

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Animal preparation and stent implantation The animal study was approved by the Ethics Committee of Chonnam National University Medical School and Chonnam National University Hospital (CNU IACUC-H-2013-36), and conformed to the Guide for the Care and Use of Laboratory Animals published by the US National Institutes of Health (NIH Publication No. 85-23, revised 1996). Study animals were castrated male pigs weighing 20-25 kg. To prevent acute thrombosis after stenting, premedication with aspirin 100 mg and clopidogrel 75 mg per day was given for 5 days before the procedure. On the procedure day, pigs were anesthetized with zolazepam and tiletamine (2.5 mg/kg, Zoletil50 ® , Virbac, Caros, France), xylazine (3 mg/kg, Rompun ® , Bayer AG, Leverkusen, Ger

show abstract

Mechanical and Histopathological Comparison between Commercialized and Newly Designed Coronary Bare Metal Stents in a Porcine Coronary Restenosis Model

Cited by 16 publications

References 27 publications

Mechanical and physio-biological properties of peptide-coated stent for re-endothelialization

Mechanical and physio-biological properties of peptide-coated stent for re-endothelialization

Effect of stents coated with a combination of sirolimus and alpha-lipoic acid in a porcine coronary restenosis model

Biodegradable Polymer-Based Sirolimus Coating Stent in a Porcine Coronary Restenosis Model

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