Mechanical Aspects of Tissue Engineering

Liebschner, Michael A. K.; Bucklen, Brandon; Wettergreen, Matthew

doi:10.1055/s-2005-919717

Cited by 23 publications

(19 citation statements)

References 61 publications

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“…Time-dependent mechanical properties have been modeled during degradation based on the change in microstructure and/or material properties of the scaffold [ 131 ]. A profile of change in scaffold mechanical properties has also been designed [ 132 ] based on a proposed profile of degradation [ 48 ]. Consequently, the variation of scaffold mechanical properties while in vitro or in vivo can be controlled/customized using factors that govern the degradation process.…”

Section: Scaffold Design For Cartilage Tissue Engineeringmentioning

confidence: 99%

“…The implementation of this strategy is practically challenging. The degradation properties of scaffolds depend on and can be modified by variables including biomaterial type and composition [ 18 ], surface chemistry [ 147 ], scaffold local environment [ 132 ], and architecture [ 148 ]. These factors can be used in the design of scaffolds to customize their degradation behavior during cartilage tissue growth in vitro or in vivo .…”

Section: Scaffold Design For Cartilage Tissue Engineeringmentioning

confidence: 99%

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Strategic Design and Fabrication of Engineered Scaffolds for Articular Cartilage Repair

Izadifar

Chen

Kulyk

2012

JFB

171

127

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Damage to articular cartilage can eventually lead to osteoarthritis (OA), a debilitating, degenerative joint disease that affects millions of people around the world. The limited natural healing ability of cartilage and the limitations of currently available therapies make treatment of cartilage defects a challenging clinical issue. Hopes have been raised for the repair of articular cartilage with the help of supportive structures, called scaffolds, created through tissue engineering (TE). Over the past two decades, different designs and fabrication techniques have been investigated for developing TE scaffolds suitable for the construction of transplantable artificial cartilage tissue substitutes. Advances in fabrication technologies now enable the strategic design of scaffolds with complex, biomimetic structures and properties. In particular, scaffolds with hybrid and/or biomimetic zonal designs have recently been developed for cartilage tissue engineering applications. This paper reviews critical aspects of the design of engineered scaffolds for articular cartilage repair as well as the available advanced fabrication techniques. In addition, recent studies on the design of hybrid and zonal scaffolds for use in cartilage tissue repair are highlighted.

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Section: Scaffold Design For Cartilage Tissue Engineeringmentioning

confidence: 99%

Section: Scaffold Design For Cartilage Tissue Engineeringmentioning

confidence: 99%

Strategic Design and Fabrication of Engineered Scaffolds for Articular Cartilage Repair

Izadifar

Chen

Kulyk

2012

JFB

171

127

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“…Bone, for example, has an exceptional list of mechanical requirements, which include the capability of providing structural rigidity to protect soft tissue organs, acting as a reservoir for minerals, and providing a framework for the transfer of muscle forces to locomotion (12,23). Therefore, the success of bone scaffold as measured in vivo is determined by its ability to participate efficiently in repairing bone defect and maintain its mechanical stability under different loading pressures.…”

Section: Mechanical Requirementsmentioning

confidence: 99%

“…Engineering (12) The main paradigm of tissue engineering is the combination of cells, growth factors, and substrates. In practice, the three are melded into an implantable tissue replacement.…”

Section: The Fourth Paradigm In Tissuementioning

confidence: 99%

Computer-Aided Tissue Engineering: Benefiting from the Control Over Scaffold Micro-Architecture

Tarawneh

Wettergreen²,

Liebschner

2012

Methods in Molecular Biology

Self Cite

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Minimization schema in nature affects the material arrangements of most objects, independent of scale. The field of cellular solids has focused on the generalization of these natural architectures (bone, wood, coral, cork, honeycombs) for material improvement and elucidation into natural growth mechanisms. We applied this approach for the comparison of a set of complex three-dimensional (3D) architectures containing the same material volume but dissimilar architectural arrangements. Ball and stick representations of these architectures at varied material volumes were characterized according to geometric properties, such as beam length, beam diameter, surface area, space filling efficiency, and pore volume. Modulus, deformation properties, and stress distributions as contributed solely by architectural arrangements was revealed through finite element simulations. We demonstrated that while density is the greatest factor in controlling modulus, optimal material arrangement could result in equal modulus values even with volumetric discrepancies of up to 10%. We showed that at low porosities, loss of architectural complexity allows these architectures to be modeled as closed celled solids. At these lower porosities, the smaller pores do not greatly contribute to the overall modulus of the architectures and that a stress backbone is responsible for the modulus. Our results further indicated that when considering a deposition-based growth pattern, such as occurs in nature, surface area plays a large role in the resulting strength of these architectures, specifically for systems like bone. This completed study represents the first step towards the development of mathematical algorithms to describe the mechanical properties of regular and symmetric architectures used for tissue regenerative applications. The eventual goal is to create logical set of rules that can explain the structural properties of an architecture based solely upon its geometry. The information could then be used in an automatic fashion to generate patient-specific scaffolds for the treatment of tissue defects.

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“…Pavyzdžiui, kauliniam audiniui keliama daug mechaninių reikalavimų. Šis audinys turi suteikti struktūrinį standumą saugant minkštųjų audinių organus, taip pat turi veikti kaip mineralinių medžiagų rezervuaras (kaulinė medžiaga yra kalcio druskų saugykla) bei suteikti pagrindą raumenims (Cowin 1989;Liebschner et al 2005). Dėl to kaulinio audinio karkaso sėkmė in vivo priklauso nuo karkaso sugebėjimo efektyviai dalyvauti taisant kaulo defektus ir užtikrinant mechaninį stabilumą esant skirtingoms apkrovoms.…”

Section: Audinių Regeneracijos Karkasinės Medžiagosunclassified

Analysis of Scaffold Materials of Implant and Tissue Regeneration / Implantų Ir Audinių Regeneracijos Karkasų Medžiagų Analizė

Mizeras

Valiulis

Šešok

et al. 2015

Mokslas – Lietuvos Ateitis

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The article presents bioinert and bioactive materials used for manufacturing implants and describes the main features and characteristics of these materials. A thorough overview and analysis of scientific works related to the properties of scaffolds for tissue regeneration and problem applicability are provided. Straipsnyje nagrinėjamos bioinertinės ir bioaktyviosios medžiagos, naudojamos medicininių implantų gamybai. Pateikiamos šių medžiagų savybės. Apžvelgiami ir analizuojami mokslo darbai, susiję su audinių regeneracijos karkasų savybėmis, naudojimo problemomis.

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Mechanical Aspects of Tissue Engineering

Cited by 23 publications

References 61 publications

Strategic Design and Fabrication of Engineered Scaffolds for Articular Cartilage Repair

Strategic Design and Fabrication of Engineered Scaffolds for Articular Cartilage Repair

Computer-Aided Tissue Engineering: Benefiting from the Control Over Scaffold Micro-Architecture

Analysis of Scaffold Materials of Implant and Tissue Regeneration / Implantų Ir Audinių Regeneracijos Karkasų Medžiagų Analizė

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