Mechanical Behaviour and Finite Element Analysis of Biomaterials: A Review

Sharma, Gaurav; Kukshal, Vikas

doi:10.1007/978-981-16-4138-1_26

Cited by 5 publications

(2 citation statements)

References 69 publications

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“…Through mechanical testing, finite element analysis, and in vivo mechanical evaluations, researchers can thoroughly characterize the mechanical features of NFMS and ensure their suitability for successful bone tissue regeneration applications. 110 4.3. Biocompatibility and Cell Recruitment/Attachment.…”

Section: Key Attributesmentioning

confidence: 99%

“…Evaluating the biomechanical compatibility of NFMS involves assessing their response to dynamic mechanical stimuli and their adaptation to changes in the in vivo environment during tissue regeneration. Through mechanical testing, finite element analysis, and in vivo mechanical evaluations, researchers can thoroughly characterize the mechanical features of NFMS and ensure their suitability for successful bone tissue regeneration applications …”

Section: Key Attributesmentioning

confidence: 99%

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Nanofibrous Microspheres: A Biomimetic Platform for Bone Tissue Regeneration

Desai,

Pande,

Vora

et al. 2024

ACS Appl. Bio Mater.

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Bone, a fundamental constituent of the human body, is a vital scaffold for support, protection, and locomotion, underscoring its pivotal role in maintaining skeletal integrity and overall functionality. However, factors such as trauma, disease, or aging can compromise bone structure, necessitating effective strategies for regeneration. Traditional approaches often lack biomimetic environments conducive to efficient tissue repair. Nanofibrous microspheres (NFMS) present a promising biomimetic platform for bone regeneration by mimicking the native extracellular matrix architecture. Through optimized fabrication techniques and the incorporation of active biomolecular components, NFMS can precisely replicate the nanostructure and biochemical cues essential for osteogenesis promotion. Furthermore, NFMS exhibit versatile properties, including tunable morphology, mechanical strength, and controlled release kinetics, augmenting their suitability for tailored bone tissue engineering applications. NFMS enhance cell recruitment, attachment, and proliferation, while promoting osteogenic differentiation and mineralization, thereby accelerating bone healing. This review highlights the pivotal role of NFMS in bone tissue engineering, elucidating their design principles and key attributes. By examining recent preclinical applications, we assess their current clinical status and discuss critical considerations for potential clinical translation. This review offers crucial insights for researchers at the intersection of biomaterials and tissue engineering, highlighting developments in this expanding field.

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Section: Key Attributesmentioning

confidence: 99%

Section: Key Attributesmentioning

confidence: 99%