Mechanical behaviour, in-vitro analysis, hemocompatibility and study of human osteosarcoma cell line proliferation of TiO2 substituted 1393-B3 borate glass

Singh, Akanksha; Goswami, Pooja; Koch, Biplob; Singh, Preetam; Pyare, Ram

doi:10.1016/j.ceramint.2024.05.159

Cited by 1 publication

(1 citation statement)

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“…Several approaches have been explored to enhance the biological fixation process and increase bioactivity. Many researchers have investigated the effects of an ion substitution and differences in the composition of chemicals on the qualities of biologically active glass, including its ability to deposit hydroxyapatite [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. Some investigations examined the relationship between electrical properties and hydroxyl apatite formation.…”

Section: Introductionmentioning

confidence: 99%

Impact of electrical polarization in the production of hydroxyapatite on ZnO substituted 45S5 bioglass

Singh,

Jaiswal,

Singh

et al. 2024

Phys. Scr.

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In the present investigation, we show the role of dielectric permittivity in the growth of hydroxyl carbonate apatite over ZnO-substituted 45S5 bioglass. ZnO is incorporated here in 45S5 bioglass because of its incipient dielectricity. Zinc is a necessary element for the formation, mineralization, development and maintenance of healthy bones. Here, the bioactive glass ZBG, having the general composition of 46.1 SiO2, 26.9 CaO, 2.6 P2O5, 24.4-X Na2O, and X ZnO (here X = 0 to 3 mole %), was synthesized using the traditional melting technique. The ZBG bioglass samples underwent electro-thermal poling with a voltage value of 10 kV at a temperature of 500 °C for 1 h. The impact of substituting Na2O with ZnO on the in-vitro bioactive property following submersion in simulated bodily fluid (SBF) was examined using the Fourier transform of infrared spectroscopy (FTIR) and x-ray diffraction (XRD). A comparison has been made between the dielectric constant (ε) and alternating current conductivity of unpolarized and polarized hydroxyl carbonate apatite (HCA) formed samples subjected to a 90 kV cm−1 polarisation field. Additionally, the influence of electrical poling on the ZBG samples that were created was examined via the use of XRD, scanning electron microscopy (SEM), energy-dispersive x-ray spectroscopy (EDX), and atomic force microscopy (AFM) research. The dielectric characteristics of bioactive glasses were improved by substituting Na2O with ZnO, as seen in the study. The ZBG samples immersed in SBF solution enhance the hydroxyl calcium phosphate precipitation process due to electrical interaction with the polarized sample. This result shows us that N-poled samples are more suitable for orthopaedic applications. Thus, our main aim of the present investigation is to increase the bioactivity of 45S5 glasses substituted with ZnO after polarization, which will be more suitable for orthopaedic implants.

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