Mechanical behaviour of porous hydroxyapatite

He, Linghui; Standard, Owen; Huang, Tiffany; Latella, Bruno A.; Swain, Michael V.

doi:10.1016/j.actbio.2007.11.002

Cited by 149 publications

(86 citation statements)

References 28 publications

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“…In other experiments, porous blocks of HA were found to be viable carriers with sustained release profiles for drugs [492] and antibiotics over 12 days [493] and 12 weeks [494], respectively. Unfortunately, porosity significantly decreases the strength of implants [233,307,325]. Thus, porous calcium orthophosphate implants cannot be loaded and are used to fill only small bone defects.…”

Section: Porositymentioning

confidence: 99%

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Untitled

2011

BIO

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In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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Section: Porositymentioning

confidence: 99%

“…Further details on the mechanical properties of calcium orthophosphate bioceramics are available elsewhere [233,325].…”

Section: Sintering and Firingmentioning

confidence: 99%

Untitled

2011

BIO

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“…Since the main mineral component present in dental enamel and dentin is hydroxyapatite (HAP), pure crystalline HAP approximates the composition of enamel and thus can be used as a representation of enamel. Pure powdered HAP, when sintered, forms spatially homogeneous solid crystalline structures 32,52,53 , but their manufacture is limited to densities above about 1.4 g/cm 3 in practical applications. 53 Difficulties are encountered when the creation of robust, dimensionally stable and reliable HAP phantoms with very low mineral concentrations is attempted.…”

Section: Measurements and Calibrationsmentioning

confidence: 99%

“…Pure powdered HAP, when sintered, forms spatially homogeneous solid crystalline structures 32,52,53 , but their manufacture is limited to densities above about 1.4 g/cm 3 in practical applications. 53 Difficulties are encountered when the creation of robust, dimensionally stable and reliable HAP phantoms with very low mineral concentrations is attempted. HAP is relatively hydrophobic and poorly soluble, and as a result, this has led some researchers to investigate other more stable materials such as dipotassium hydrogen phosphate (K2HPO4) [54][55][56][57] and lithium tetraborate (Li2B4O7).…”

Section: Measurements and Calibrationsmentioning

confidence: 99%

Theory of X-ray microcomputed tomography in dental research: application for the caries research

Park

Bae

Chang

et al. 2011

J Korean Acad Conserv Dent

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Caries remains prevalent throughout modern society and is the main disease in the field of dentistry. Although studies of this disease have used diverse methodology, recently, X-ray microtomography has gained popularity as a non-destructive, 3-dimensional (3D) analytical technique, and has several advantages over the conventional methods. According to X-ray source, it is classified as monochromatic or polychromatic with the latter being more widely used due to the high cost of the monochromatic source despite some advantages. The determination of mineral density profiles based on changes in X-ray attenuation is the principle of this method and calibration and image processing procedures are needed for the better image and reproducible measurements. Using this tool, 3D reconstruction is also possible and it enables to visualize the internal structures of dental caries. With the advances in the computer technology, more diverse applications are being studied, such automated caries assessment algorithms.

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“…HA has poor mechanical properties, low strength and toughness and lack of flexibility, which may restrict its applications in load-bearing implantation sites [2, 3, 15,18]. The mechanical properties increase with an increasing Ca/P ratio, but decrease with increasing porosity [51]. The tensile strength for dense HA is between 79 to 106 MPa, and for porous HA around 42 MPa [13], the compressive strength of up to 900 MPa, which is higher than the strength in cortical bone.…”

Section: Characterization and Preparation Of Synthetic Hamentioning

confidence: 99%

Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

Götz¹,

Papageorgiou²

2017

CPB

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Bone grafts are widely used for augmentation procedures in oral and maxillofacial surgery, with autogenous bone being the gold standard. Recently, the focus of research has shifted towards synthetic bone substitutes, as no second surgery is needed and large quantities of graft can easily be provided. Within the broad range of bone substitutes, synthetic hydroxyapatite has drawn much attention, as they are considered to be biocompatible, non-immunogenic, osteoconductive and osteoinductive. Scope of this review is to summarize existing knowledge concerning the molecular, cellular and pharmaceutical aspects of synthetic bone substitutes for oral and maxillofacial grafting.

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Mechanical behaviour of porous hydroxyapatite

Cited by 149 publications

References 28 publications

Untitled

Untitled

Theory of X-ray microcomputed tomography in dental research: application for the caries research

Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

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