Mechanical destruction using a minimally invasive Ultrasound Needle induces anti-tumor immune responses and synergizes with the anti-PD-L1 blockade

Tang, Jianmin; Tang, Junhui; Li, Hui; Zhou, Jing; Tang, Najiao; Wang, Xinxin; Zhu, Bo; Li, Ningshan; Liu, Zheng

doi:10.1016/j.canlet.2022.216009

Cited by 10 publications

(5 citation statements)

References 47 publications

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“…Therefore, normalizing tumor vascularization is proposed as an efficient way of either decreasing IFP or increasing TILs [ 90 , 148 ]. UTMC was compared with T-HIFU in a MC38 murine model in combination with aPD-L1 [ 180 ]. Although the authors reported ablative UTMC, we believe it should be considered non-ablative, given that tumor perfusion was maintained after UTMC.…”

Section: Immune Profiles Fus Bioeffects and Icimentioning

confidence: 99%

“…Although the authors reported ablative UTMC, we believe it should be considered non-ablative, given that tumor perfusion was maintained after UTMC. In this study, UTMC was more efficient in inducing an abscopal effect; mechanical perturbation by UTMC improved mouse survival following UTMC + aPD-L1 therapy by increasing the expression of DAMPs; enhancing the tumor infiltration of CTLs, DCs, TAMs; and reducing Tregs and MDSCs [ 180 ].…”

Section: Immune Profiles Fus Bioeffects and Icimentioning

confidence: 99%

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Fundamentals and Applications of Focused Ultrasound-Assisted Cancer Immune Checkpoint Inhibition for Solid Tumors

Jahangiri,

2024

Pharmaceutics

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Despite spectacular clinical successes across several cancer types, immune checkpoint inhibition is effective only in subgroups of patients and suffers from significant systemic toxicities, highlighting the need to understand and locally overcome the mechanisms of therapeutic resistance. Similarly to other therapeutics, immunotherapies face delivery challenges (for example, antibodies need to reach their targets) and immunological barriers that are unique to solid tumors and their microenvironment. Interestingly, focused ultrasound (FUS), with or without microbubbles, which has been shown to enhance gene and drug delivery, notably in oncology, has been recently found to trigger immunological responses. In recent years, there has been a strong emphasis on understanding the biological and immunological effects of FUS for cancer therapy, and FUS is now emerging as an approach that can improve cancer immunotherapy. We herein review: (1) the immunological barriers implicated in ICI resistance; (2) the fundamentals of FUS +/− MB and the current knowledge on leveraging FUS +/− MB bioeffects for improving ICI therapy efficacy; (3) the immune profile of tumor models that have been successfully treated with FUS and ICI; and finally, (4) we discuss the challenges ahead for translating FUS and MB treatments to the clinic, highlighting the exciting perspectives for this new research area.

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Section: Immune Profiles Fus Bioeffects and Icimentioning

confidence: 99%

Section: Immune Profiles Fus Bioeffects and Icimentioning

confidence: 99%

Fundamentals and Applications of Focused Ultrasound-Assisted Cancer Immune Checkpoint Inhibition for Solid Tumors

Jahangiri,

2024

Pharmaceutics

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“…Recently, it was reported that UTMD plays an indispensable role in enhancing the transfection efficiency of tumor suppressor genes and cytokines and promoting the recruitment of T cells at tumor targeted sites. We detected its synergistic efficacy in the treatment of tumors with anti-PD-L1 antibody in a mouse tumor model ( Ilovitsh et al, 2020 ; Tang et al, 2023 ). By combining ultrasound with tumor targeting microbubbles, Hu J team showed that USNB promoted the infiltration and antitumor activity of CD8 + T cells ( Sun et al, 2023 ).…”

Section: Mechanism and Application Of Ultrasound Combined With Microb...mentioning

confidence: 99%

Ultrasound combined with microbubble mediated immunotherapy for tumor microenvironment

Wu,

Li,

Shu

et al. 2024

Front. Pharmacol.

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The tumor microenvironment (TME) plays an important role in dynamically regulating the progress of cancer and influencing the therapeutic results. Targeting the tumor microenvironment is a promising cancer treatment method in recent years. The importance of tumor immune microenvironment regulation by ultrasound combined with microbubbles is now widely recognized. Ultrasound and microbubbles work together to induce antigen release of tumor cell through mechanical or thermal effects, promoting antigen presentation and T cells’ recognition and killing of tumor cells, and improve tumor immunosuppression microenvironment, which will be a breakthrough in improving traditional treatment problems such as immune checkpoint blocking (ICB) and himeric antigen receptor (CAR)-T cell therapy. In order to improve the therapeutic effect and immune regulation of TME targeted tumor therapy, it is necessary to develop and optimize the application system of microbubble ultrasound for organs or diseases. Therefore, the combination of ultrasound and microbubbles in the field of TME will continue to focus on developing more effective strategies to regulate the immunosuppression mechanisms, so as to activate anti-tumor immunity and/or improve the efficacy of immune-targeted drugs, At present, the potential value of ultrasound combined with microbubbles in TME targeted therapy tumor microenvironment targeted therapy has great potential, which has been confirmed in the experimental research and application of breast cancer, colon cancer, pancreatic cancer and prostate cancer, which provides a new alternative idea for clinical tumor treatment. This article reviews the research progress of ultrasound combined with microbubbles in the treatment of tumors and their application in the tumor microenvironment.

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“…In addition to the mechanical effects generated by the gas nucleus, the ultrasonic horn, an acoustic device with an operating frequency of 20–40 kHz and a pressure amplitude of more than several hundred kilopascals at the horn tip, also produce direct mechanical destruction and strong cavitation, which provides the possibility of destroying tumors by increasing tumor antigen exposure to improve the efficiency of the immune response [ 137 ]. Tang et al [ 138 ] modified the ultrasonic horn to prepare a new type of device, which is called the ultrasonic needle (UN). By inducing antitumor immunity through mechanical destruction of UN, and combining with αPD-L1, it provides a new idea for ultrasound-assisted immunotherapy.…”

Section: Ismt For Cancermentioning

confidence: 99%

Nanomaterials augmented bioeffects of ultrasound in cancer immunotherapy

Xie,

Zhang,

Wang

et al. 2024

Materials Today Bio

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Mechanical destruction using a minimally invasive Ultrasound Needle induces anti-tumor immune responses and synergizes with the anti-PD-L1 blockade

Cited by 10 publications

References 47 publications

Fundamentals and Applications of Focused Ultrasound-Assisted Cancer Immune Checkpoint Inhibition for Solid Tumors

Fundamentals and Applications of Focused Ultrasound-Assisted Cancer Immune Checkpoint Inhibition for Solid Tumors

Ultrasound combined with microbubble mediated immunotherapy for tumor microenvironment

Nanomaterials augmented bioeffects of ultrasound in cancer immunotherapy

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