Mechanical enhancement of graphene oxide-filled chitosan-based composite hydrogels by multiple mechanisms

Huang, Yiwan; Xiao, Longya; Zhou, Ju; Li, Xuefeng; Liu, Jianxin; Zeng, Ming

doi:10.1007/s10853-020-05063-x

Cited by 24 publications

(10 citation statements)

References 28 publications

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“…This may be because, despite GO's exceptional mechanical resistance, gelatin starts to degrade faster at the rich GO clusters, most likely due to mechanical stress propagation at such sites. This appears to be exacerbated when GO has sufficient space for displacement, i.e., at the lower concentration of 0.1 mg/mL [93][94][95][96].…”

Section: Mechanical Resistance Evaluationmentioning

confidence: 99%

Gelatin-Graphene Oxide Nanocomposite Hydrogels for Kluyveromyces lactis Encapsulation: Potential Applications in Probiotics and Bioreactor Packings

et al. 2021

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Nutraceutical formulations based on probiotic microorganisms have gained significant attention over the past decade due to their beneficial properties on human health. Yeasts offer some advantages over other probiotic organisms, such as immunomodulatory properties, anticancer effects and effective suppression of pathogens. However, one of the main challenges for their oral administration is ensuring that cell viability remains high enough for a sustained therapeutic effect while avoiding possible substrate inhibition issues as they transit through the gastrointestinal (GI) tract. Here, we propose addressing these issues using a probiotic yeast encapsulation strategy, Kluyveromyces lactis, based on gelatin hydrogels doubly cross-linked with graphene oxide (GO) and glutaraldehyde to form highly resistant nanocomposite encapsulates. GO was selected here as a reinforcement agent due to its unique properties, including superior solubility and dispersibility in water and other solvents, high biocompatibility, antimicrobial activity, and response to electrical fields in its reduced form. Finally, GO has been reported to enhance the mechanical properties of several materials, including natural and synthetic polymers and ceramics. The synthesized GO-gelatin nanocomposite hydrogels were characterized in morphological, swelling, mechanical, thermal, and rheological properties and their ability to maintain probiotic cell viability. The obtained nanocomposites exhibited larger pore sizes for successful cell entrapment and proliferation, tunable degradation rates, pH-dependent swelling ratio, and higher mechanical stability and integrity in simulated GI media and during bioreactor operation. These results encourage us to consider the application of the obtained nanocomposites to not only formulate high-performance nutraceuticals but to extend it to tissue engineering, bioadhesives, smart coatings, controlled release systems, and bioproduction of highly added value metabolites.

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Section: Mechanical Resistance Evaluationmentioning

confidence: 99%

Gelatin-Graphene Oxide Nanocomposite Hydrogels for Kluyveromyces lactis Encapsulation: Potential Applications in Probiotics and Bioreactor Packings

et al. 2021

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“…[ 12,13 ] To overcome such obstacle, several strategies have been developed. [ 12,14–19 ] Among them, double‐network (DN) hydrogels, consisting of a densely cross‐linked first network and a loosely cross‐linked second network, show a high strength (megapascal level) and high fracture energy (≈10 3 J m −2 ). [ 13,20,21 ] The outstanding mechanical properties of the DN gels are attributed to the covalent bonds breakage of the first network when resisting deformation and crack, providing numerous sacrificial bonds to prevent bulk failure of the material.…”

Section: Introductionmentioning

confidence: 99%

Strong Tough Polyampholyte Hydrogels via the Synergistic Effect of Ionic and Metal–Ligand Bonds

Huang

Xiao

Zhou

et al. 2021

Adv Funct Materials

Self Cite

135

126

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Despite existing in biological systems, developing synthetic polyampholyte (PA) hydrogels constructed by both ionic and metal–ligand bonds remains challenging. Herein, a simple secondary equilibrium approach is proposed to fabricate strong and tough PA hydrogels via the synergy of ionic and metal–ligand bonds. The original PA gels (constructed by ionic bonds) are first dialyzed in multivalent metal‐ion solutions to reach a swelling equilibrium and then moved to deionized water to dialyze excess free ions to achieve a new equilibrium. Through this approach, the original PA gel network can be optimized and eventually constructed by ionic and metal–ligand bonds, enabling a synergistic reinforcement. By selecting different original PA gel systems and diverse multivalent metal‐ions, the proposed approach is proved to be generalizable to fabricate strong and tough PA gels. Additionally, the hydrogels have stable ion‐conductivity even at the water‐equilibrium state, making them promising as strain sensors. The viscoelastic and elastic contributions to the mechanical properties of the hydrogels by a viscoelastic model are also discussed to further understand the strengthening and toughening mechanisms. The proposed strategy is simple but effective for achieving strong and tough PA‐based hydrogels. This study also provides new insights for PA hydrogels in electrolyte environments.

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“…These coatings can improve the biocompatibility and functionality of medical implants, reducing the risk of adverse reactions and promoting better integration with the surrounding tissues. Huang et al 41 investigated a strategy to enhance the mechanical properties of chitosan-based composite hydrogels. Chitosan is a favorable material for making hydrogels due to its hydrophilic and biocompatible nature.…”

Section: Nanocomposite Hydrogel Formulation and Designmentioning

confidence: 99%

Revolutionizing biomedicine: advancements, applications, and prospects of nanocomposite macromolecular carbohydrate-based hydrogel biomaterials: a review

Alshangiti,

El-damhougy,

Zaher

et al. 2023

RSC Adv.

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Mechanical enhancement of graphene oxide-filled chitosan-based composite hydrogels by multiple mechanisms

Cited by 24 publications

References 28 publications

Gelatin-Graphene Oxide Nanocomposite Hydrogels for Kluyveromyces lactis Encapsulation: Potential Applications in Probiotics and Bioreactor Packings

Gelatin-Graphene Oxide Nanocomposite Hydrogels for Kluyveromyces lactis Encapsulation: Potential Applications in Probiotics and Bioreactor Packings

Strong Tough Polyampholyte Hydrogels via the Synergistic Effect of Ionic and Metal–Ligand Bonds

Revolutionizing biomedicine: advancements, applications, and prospects of nanocomposite macromolecular carbohydrate-based hydrogel biomaterials: a review

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