Mechanical, In vitro Antimicrobial, and Biological Properties of Plasma-Sprayed Silver-Doped Hydroxyapatite Coating

Roy, Mousumi; Fielding, Gary; Beyenal, Haluk; Bandyopadhyay, Amit; Bose, Susmita

doi:10.1021/am201610q

Cited by 175 publications

(104 citation statements)

References 52 publications

Supporting

Mentioning

100

Contrasting

Unclassified

Order By: Relevance

“…23 This is probably, on the one hand, due to the constraints of the fivemembered ring that do not allow the optimum orientation of the lone pair on the nitrogen atoms, and, on the other hand, due to the larger basicity of the secondary amine. All of the remaining amino acids are predicted to coordinate in a tridentate fashion with side chain participation (5). In these cases, the silver-coordination bonds with the termini are elongated as compared to the bidentate structures of the unpolar, aliphatic amino acids (by ca.…”

Section: Silver Binding To Amino Acids and Peptidesmentioning

confidence: 99%

Nanobio Silver: Its Interactions with Peptides and Bacteria, and Its Uses in Medicine

et al. 2013

View full text Add to dashboard Cite

Introduction 4708 2. Peptides and Silver 4709 2.1. Silver Binding to Amino Acids and Peptides 4709 2.1.1. Silver Binding to Amino Acids − Theory 4709 2.1.2. Silver Binding to Amino Acids − Experiment 4711 2.1.3. Silver Binding to Peptides 4711 2.2. Natural Peptides Involved in Metal Detoxification 4714 2.3. Peptides for the Formation of Silver Nanostructures 4716 2.3.1. Biomineralization of Silver by Means of Peptides 4716 2.3.2. Peptides as Structure-Determining Scaffolds in the Synthesis of Silver Nanostructures 4721 3. Bacteria and Silver 4722 3.1. Antimicrobial Properties of Silver-Containing Compounds 4722 3.1.1. Interactions with the Bacterial Cell Wall 4722 3.1.2. Interactions with DNA, Enzymes, and Membrane Proteins 4724 3.1.3. Generation of Reactive Oxygen Species 4725 3.2. Bacterial Resistance Mechanisms against Ag(I) 4726 3.2.1. Accumulation and Storage-Based Mechanism 4726 3.2.2. Efflux Pump-Based Mechanism 4727 3.3. Synthesis of Silver Nanoparticles by Means of Bacteria 4728 4. Silver-Based Biomaterials in the Medical Field 4730 4.1. Types of Silver-Containing Biomaterials 4731 4.1.1. Metallic Silver Coatings and Silver's Antimicrobial Efficiency 4731 4.1.2. Silver-Containing Nanocomposites 4732 4.1.3. Silver-Containing Polymers 4732 4.1.4. Surface Modification with Ionic Silver Compounds 4734 4.1.5. Hybrid Silver Materials − Synergistic Effects 4734 4.2. Deposition Processes 4735 4.3. Mechanical Properties 4736 5. Biocompatibility of Silver 4737 5.1. General Routes of Silver Exposure 4737 5.2. Exposure to Silver-Containing Medical Products 4737 5.2.1. Dermal Contact: Burn Wound Dressings 4737 5.2.2. Bone Contact: Orthopedic and Dental Implants and Bone-Filling Products 4738 5.2.3. Blood Contact: Implants Introduced into the Vascular System 4739 5.3. Effects of Silver Exposure on Tissues and Organs 4739 5.3.1. Acute and Chronic Toxicity of Silver 4740 5.3.2. Tissue and Organ Damages 4740 5.3.3. Cellular Uptake of Silver 4741 5.4. Toxic Effects of Silver Nanoparticles 4741 5.5. Silver Detoxification 4742 5.5.1. Sequestration of Silver Ions 4742 5.5.2. Silver Ion Transport by ATPase P-type Efflux Pumps 4743 6. Conflicting Evidence 4744 7. Conclusions 4744 Author Information 4744 Corresponding Author 4744 Notes 4744 Biographies 4745 Acknowledgments 4746 References 4746

show abstract

Section: Silver Binding To Amino Acids and Peptidesmentioning

confidence: 99%

Nanobio Silver: Its Interactions with Peptides and Bacteria, and Its Uses in Medicine

et al. 2013

View full text Add to dashboard Cite

show abstract

“…The efficacy of the Ag-HAp coatings on titanium substrates against P. aeruginosa adhesion and colonization was investigated and demonstrated by live/dead fluorescence staining [208] (Fig. 4b).…”

Section: Influence Of Agmentioning

confidence: 99%

“…Moreover, it has to be taken into account that excessive silver content within hydroxyapatite may be toxic, not only towards microorganisms but also towards mammalian tissues, and may lead to the inhibition of their growth and development and to their death in the case of too high Ag + amounts [190,207,208], toxic silver concentrations being in the range 1-3 μg/ml [191]. Thus, it is fundamental to select the silver doping amount in order to effectively kill microorganisms, without adversely influencing the mammalian tissue condition.…”

Section: Influence Of Agmentioning

confidence: 99%

Cationic and Anionic Substitutions in Hydroxyapatite

Cacciotti¹

2016

Handbook of Bioceramics and Biocomposites

View full text Add to dashboard Cite

“…47 Accordingly, silver released from the Ag-PIII samples to PBS after a 30-day incubation was evaluated by inductively coupled plasma mass spectrometry. As shown in Figure 4, the amounts of silver released from 30 min-15 Ag-PIII, 60 min-15 Ag-PIII, and 90 min-15 Ag-PIII were 3.6 ppb, 4.3 ppb, and 4.6 ppb, respectively, signifying that the leakages of silver from Ag-PIII samples were minimal.…”

Section: Silver Releasementioning

confidence: 99%

Hierarchical micro/nanostructured titanium with balanced actions to bacterial and mammalian cells for dental implants

Zhu

Cao

Qiao

et al. 2015

IJN

View full text Add to dashboard Cite

A versatile strategy to endow dental implants with long-term antibacterial ability without compromising the cytocompatibility is highly desirable to combat implant-related infection. Silver nanoparticles (Ag NPs) have been utilized as a highly effective and broad-spectrum antibacterial agent for surface modification of biomedical devices. However, the high mobility and subsequent hazardous effects of the particles on mammalian cells may limit its practical applications. Thus, Ag NPs were immobilized on the surface of sand-blasted, large grit, and acid-etched (SLA) titanium by manipulating the atomic-scale heating effect of silver plasma immersion ion implantation. The silver plasma immersion ion implantation-treated SLA surface gave rise to both good antibacterial activity and excellent compatibility with mammalian cells. The antibacterial activity rendered by the immobilized Ag NPs was assessed using Fusobacterium nucleatum and Staphylococcus aureus , commonly suspected pathogens for peri-implant disease. The immobilized Ag NPs offered a good defense against multiple cycles of bacteria attack in both F. nucleatum and S. aureus , and the mechanism was independent of silver release. F. nucleatum showed a higher susceptibility to Ag NPs than S. aureus , which might be explained by the presence of different wall structures. Moreover, the immobilized Ag NPs had no apparent toxic influence on the viability, proliferation, and differentiation of rat bone marrow mesenchymal stem cells. These results demonstrated that good bactericidal activity could be obtained with very small quantities of immobilized Ag NPs, which were not detrimental to the mammalian cells involved in the osseointegration process, and promising for titanium-based dental implants with commercial SLA surfaces.

show abstract

Mechanical, In vitro Antimicrobial, and Biological Properties of Plasma-Sprayed Silver-Doped Hydroxyapatite Coating

Cited by 175 publications

References 52 publications

Nanobio Silver: Its Interactions with Peptides and Bacteria, and Its Uses in Medicine

Nanobio Silver: Its Interactions with Peptides and Bacteria, and Its Uses in Medicine

Cationic and Anionic Substitutions in Hydroxyapatite

Hierarchical micro/nanostructured titanium with balanced actions to bacterial and mammalian cells for dental implants

Contact Info

Product

Resources

About