Mechanical, morphological and comparative properties of microbeads assembled from carboxylated cellulose nanocrystals

Wu, Junqi; Andrews, Mark P.

doi:10.1039/d3ta05298b

J. Mater. Chem. A

2024

DOI: 10.1039/d3ta05298b

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Mechanical, morphological and comparative properties of microbeads assembled from carboxylated cellulose nanocrystals

Junqi Wu,

Mark P. Andrews

Abstract: While carboxylated cellulose nanocrystal (cCNC) microbeads are an emerging class of sustainable alternatives to microplastics, their expanded potential lies in diverse fields like drug delivery, cosmetics and personal care, agriculture,...

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Vibration-assisted Microbead Production: A New Frontier for Biocompatible Surfaces

Yingngam,

Makewilai,

Chaisawat

et al. 2024

Medical Applications for Biocompatible Surfaces and Coatings

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The encapsulation of active pharmaceutical ingredients (APIs) in microbeads is an essential step in drug delivery; however, it is also inherently associated with the need to control particle size and drug release profiles. Nevertheless, most conventional methods of microencapsulation fail to provide consistent results. A new method called vibration-assisted microbead coating is a novel unified technique utilizing mechanical vibrations to enable the controlled, uniform coating of microbeads on APIs. This chapter discusses the technology of vibration-assisted encapsulation performed by the authors through microbead formation and the physical activity of coating APIs. This chapter focuses on achieving uniform control of the final coated surface of the API, microbead shape, size, and loading through vibration parameters. Additionally, this chapter discusses the biocompatibility and stability of the final coated surface. This new means of encapsulation has high potential for drug delivery. This method reduces most of the traditional challenges of encapsulation, if not eliminates them, and is more reliable. Based on the abovementioned findings, the authors propose the following main areas for their further work: optimisation of vibration parameters for various APIs, research into the long-term stability of the loading–release profile, and possible use of the technique in targeted drug delivery.

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Vibration-assisted Microbead Production: A New Frontier for Biocompatible Surfaces

Yingngam,

Makewilai,

Chaisawat

et al. 2024

Medical Applications for Biocompatible Surfaces and Coatings

View full text Add to dashboard Cite

show abstract

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Mechanical, morphological and comparative properties of microbeads assembled from carboxylated cellulose nanocrystals

Abstract: While carboxylated cellulose nanocrystal (cCNC) microbeads are an emerging class of sustainable alternatives to microplastics, their expanded potential lies in diverse fields like drug delivery, cosmetics and personal care, agriculture,...

Cited by 1 publication

References 52 publications

Vibration-assisted Microbead Production: A New Frontier for Biocompatible Surfaces

Vibration-assisted Microbead Production: A New Frontier for Biocompatible Surfaces

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