Mechanical properties and in vitro biocompatibility evaluation of TiN/TiO2 coated Ti6Al4V alloy

Ormanova

et al. 2021

IJMS

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Vacuum cathodic arc TiN coatings with overlaying TiO2 film were deposited on polished and surface roughened by electron beam modification (EBM) Ti6Al4V alloy. The substrate microtopography consisted of long grooves formed by the liner scan of the electron beam with appropriate frequencies (500 (AR500) and 850 (AR850) Hz). EBM transformed the α + β Ti6Al4V mixed structure into a single α’-martensite phase. Тhe gradient TiN/TiO2 films deposited on mechanically polished (AR) and EBM (AR500 and AR850) alloys share the same surface chemistry and composition (almost stoichiometric TiN, anatase and rutile in different ratios) but exhibit different topographies (Sa equal to approximately 0.62, 1.73, and 1.08 μm, respectively) over areas of 50 × 50 μm. Although the nanohardness of the coatings on AR500 and AR850 alloy (approximately 10.45 and 9.02 GPa, respectively) was lower than that measured on the film deposited on AR alloy (about 13.05 GPa), the hybrid surface treatment offered improvement in critical adhesive loads, coefficient of friction, and wear-resistance of the surface. In phosphate buffer saline, all coated samples showed low corrosion potentials and passivation current densities, confirming their good corrosion protection. The coated EBM samples cultured with human osteoblast-like MG63 cells demonstrated increased cell attachment, viability, and bone mineralization activity especially for the AR500-coated alloy, compared to uncoated polished alloy. The results underline the synergetic effect between the sub-micron structure and composition of TiN/TiO2 coating and microarchitecture obtained by EBM.

Section: Introductionmentioning

confidence: 69%

Electrochemical, Tribological and Biocompatible Performance of Electron Beam Modified and Coated Ti6Al4V Alloy

Ormanova

et al. 2021

IJMS

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“…The coated samples displayed better cell attachment and cytocompatibility with no negative effects on MG63 cells ( Figure 5). [130]. The coated samples displayed better cell attachment and cytocompatibility with no negative effects on MG63 cells ( Figure 5).…”

Section: Nano-oxides In Hard Tissue Regenerationmentioning

confidence: 92%

“…Our research group found out that electron beam surface treatment of titanium alloy not only increased the surface micro-and nano roughness [128] but also decreased the surface hardness of the magnetron sputtered TiN with overlaying TiO 2 coating bringing it closer to that of trabecular bone and human teeth and decreasing the elastic modulus mismatch between the bone and implant [129]. Moreover, nanostructured arc PVD deposited TiN with overlaying glow-plasma discharge deposited TiO 2 coating indicated an increase in MG63 cell viability by almost 100% after 24 h relative to the bare Ti6Al4V alloys [130]. The coated samples displayed better cell attachment and cytocompatibility with no negative effects on MG63 cells ( Figure 5).…”

Section: Nano-oxides In Hard Tissue Regenerationmentioning

confidence: 99%

Metal Oxide Nanoparticles as Biomedical Materials

Chavali²

2020

Biomimetics

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344

146

The development of new nanomaterials with high biomedical performance and low toxicity is essential to obtain more efficient therapy and precise diagnostic tools and devices. Recently, scientists often face issues of balancing between positive therapeutic effects of metal oxide nanoparticles and their toxic side effects. In this review, considering metal oxide nanoparticles as important technological and biomedical materials, the authors provide a comprehensive review of researches on metal oxide nanoparticles, their nanoscale physicochemical properties, defining specific applications in the various fields of nanomedicine. Authors discuss the recent development of metal oxide nanoparticles that were employed as biomedical materials in tissue therapy, immunotherapy, diagnosis, dentistry, regenerative medicine, wound healing and biosensing platforms. Besides, their antimicrobial, antifungal, antiviral properties along with biotoxicology were debated in detail. The significant breakthroughs in the field of nanobiomedicine have emerged in areas and numbers predicting tremendous application potential and enormous market value for metal oxide nanoparticles.

“…Consequently, magnetron sputtering technology now significantly impacts many application areas, including low friction coatings, corrosion-resistant coatings, coatings and films for modern biomedicine, etc. [26,27]. The authors of [26,27] showed that 3.7 µm thick TiN/TiO 2 bilayer coatings deposited on Ti6Al4V alloy by DC magnetron sputtering exhibited high bioactivity and improved corrosion resistance.…”

Section: Of 13mentioning

confidence: 99%

Influence of Thickness on the Structure and Biological Response of Cu-O Coatings Deposited on cpTi

Ilievska,

Ivanova,

Dechev

et al. 2024

Coatings

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This work presents results on the influence of thickness on the structure and biological response of Cu-O coatings deposited on commercially pure titanium (cpTi) substrates using direct current (DC) magnetron sputtering. The deposition times were 5, 10, and 15 min to obtain coatings with different thicknesses. The results show that the films deposited for 5, 10, and 15 min correspond to thicknesses of 41, 74, and 125 nm, respectively. The phase composition of the coatings is in the form of a double-phase structure of CuO and Cu2O in all considered cases. The roughness is on the nanometric scale and no obvious trend as a function of the thickness can be observed for the deposited films. Also, it was found that, with an increase in the thickness of the films, the distribution of the heights becomes closer to symmetrical. The antimicrobial efficacy of different Cu-O-coated cpTi substrates was examined using a direct contact experiment. A possible bactericidal effect was investigated by inoculating a 200 μL bacterial suspension on CuO-coated cpTi and cpTi (control) for 24 h at 37 °C. The results showed that Cu-O-coated cpTi substrates have a 50%–60% higher antimicrobial activity than the substrate. At the same time, human osteosarcoma (MG-63) cells growing on Cu-O-coated cpTi substrates showed 80% viability following 24 h incubation. Depending on magnetron sputtering process parameters, a different coating thickness, various crystallite phase compositions, and diverse biocompatibility were obtained.