Mechanical properties of gastrointestinal smooth muscle

Meiss, Richard A.

doi:10.1002/cphy.cp060108

Cited by 11 publications

(9 citation statements)

References 281 publications

(235 reference statements)

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“…Esophageal compliance seems to depend on three important mechanisms: active contractility, an "in-parallel" elastic component, and an "in-series" elastic component (18). We speculate that the similar alteration in compliance observed in both GERD-related and achalasia aperistalsis could result from alterations of the same or different compliance mechanisms.…”

Section: Discussionmentioning

confidence: 80%

Esophageal tone in patients with total aperistalsis: gastroesophageal reflux disease versus achalasia

Mearin

Vásconez

Zárate

et al. 2000

American Journal of Physiology-Gastrointestinal and Liver Physi

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We have evaluated esophageal tone in two different conditions that, in some cases, similarly impair phasic esophageal motility. Studies were performed in 14 healthy volunteers, 10 patients with total esophageal aperistalsis secondary to gastroesophageal reflux disease (GERD), and 25 untreated achalasia patients. We quantified esophageal compliance and relaxation induced by a nitric oxide donor using a barostat. Intraesophageal volume at a minimal distending pressure (2 mmHg) was not significantly different among all three groups (4.1 +/- 0.7, 3.8 +/- 0.7, and 4.2 +/- 1.2 ml for healthy, GERD, and achalasia groups, respectively). Esophageal compliance was significantly increased (P < 0.05 vs. healthy group) in the two groups of patients with aperistalsis (1.9 +/- 0.2, 3.0 +/- 0.2, and 3.1 +/- 0.3 ml/mmHg for healthy, GERD, and achalasia groups, respectively). Esophageal relaxation was decreased in GERD patients (Delta diameter: 0.4 +/- 0.1 cm) and increased in achalasia patients (Delta diameter: 1.3 +/- 0.4 cm) relative to healthy subjects (Delta diameter: 0.9 +/- 0.2 cm) (P < 0.05 for GERD vs. achalasia and healthy groups). Our results indicate that diseases that similarly impair phasic esophageal motility may affect esophageal tone differently.

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Section: Discussionmentioning

confidence: 80%

Esophageal tone in patients with total aperistalsis: gastroesophageal reflux disease versus achalasia

Mearin

Vásconez

Zárate

et al. 2000

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…These findings are attributed to an initial resistance to distension due to resting tone (less compliant), followed by a decrease in tone due to receptive reflex‐mediated relaxation (more compliant), and finally increased resistance to stretch as the lengthening is limited by less compliant passive elastic components 8,18,27 . Another factor that contributes to the more compliant accommodation phase after application of a rapid stress to a viscoelastic system is ‘stress relaxation’, 29 and will be seen with either technique.…”

Section: Rectal Compliancementioning

confidence: 99%

Abnormal rectal motor physiology in patients with irritable bowel syndrome

Kwan

Davis

Mikula

et al. 2004

Neurogastroenterology Motil

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A contentious issue is whether irritable bowel syndrome (IBS) patients have abnormal rectal motor physiology. Our aim was to determine whether IBS patients have abnormal rectal responses to low (urge producing) or high (pain producing) distension pressures. The IBS patients and healthy controls underwent five series of isobaric rectal distensions to examine volume-pressure relationships and rectal accommodation: (i) ascending stepwise distensions terminating upon report of moderate pain, (ii) phasic and (iii) tonic distensions at a single low pressure producing a moderate sensation of urge to defecate (iv) phasic and (v) tonic distensions at a single high pressure producing a moderate pain sensation. The IBS patients demonstrated a lower rectal volume-pressure ratio during repetitive single-pressure phasic distensions, and a slower rate of rectal accommodation during low (but not high) pressure tonic distensions. However, dynamic compliance during ascending stepwise distensions and the change in rectal volume during tonic distension were not significantly different from controls. Rectal abnormality was readily demonstrated by determining the volume-pressure ratio using a small number of repetitive single-pressure distensions, supporting the hypothesis that IBS patients have abnormal rectal motor physiology. We propose that a peripheral neuromuscular substrate may contribute to the pathogenesis of IBS.

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“…From a mechanical point of view the intestinal wall can be regarded as a viscoelastic body (Meiss, 2011). The “three-element model” proposed by Hill (1938, 1970) considers the tissue to be composed of a “contractile element,” responsible for the “active component” of the muscle, connected with a “series elastic element,” and a “parallel element” to describe the connective tissue.…”

Section: Introductionmentioning

confidence: 99%

“…The “three-element model” proposed by Hill (1938, 1970) considers the tissue to be composed of a “contractile element,” responsible for the “active component” of the muscle, connected with a “series elastic element,” and a “parallel element” to describe the connective tissue. The parallel elastic component seems to consist of the connective tissue as the contractile element of smooth muscle which by itself does not contribute significantly to the passive tension (Weems, 1981; Fung, 1993; Gregersen and Kassab, 1996; Gregersen, 2002; Nicosia and Brasseur, 2002; Gregersen et al, 2009; Meiss, 2011). …”

Section: Introductionmentioning

confidence: 99%

“…The intestinal wall is composed of several layers including smooth muscle, mucosa, and connective tissue, and collectively these can be regarded as a viscoelastic body (Meiss, 2011). The mechanical properties of this body have been described by Hill (1938, 1970) as a “three-element model” in which the tissue is composed of a “contractile element,” responsible for the “active component” of the muscle, connected with a “series elastic element,” and a “parallel element” to describe the connective tissue.…”

Section: Introductionmentioning

confidence: 99%

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An experimental method to identify neurogenic and myogenic active mechanical states of intestinal motility

Costa¹,

Wiklendt²,

Arkwright³

et al. 2013

Front. Syst. Neurosci.

118

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Excitatory and inhibitory enteric neural input to intestinal muscle acting on ongoing myogenic activity determines the rich repertoire of motor patterns involved in digestive function. The enteric neural activity cannot yet be established during movement of intact intestine in vivo or in vitro. We propose the hypothesis that is possible to deduce indirectly, but reliably, the state of activation of the enteric neural input to the muscle from measurements of the mechanical state of the intestinal muscle. The fundamental biomechanical model on which our hypothesis is based is the “three-element model” proposed by Hill. Our strategy is based on simultaneous video recording of changes in diameters and intraluminal pressure with a fiber-optic manometry in isolated segments of rabbit colon. We created a composite spatiotemporal map (DPMap) from diameter (DMap) and pressure changes (PMaps). In this composite map rhythmic myogenic motor patterns can readily be distinguished from the distension induced neural peristaltic contractions. Plotting the diameter changes against corresponding pressure changes at each location of the segment, generates “orbits” that represent the state of the muscle according to its ability to contract or relax actively or undergoing passive changes. With a software developed in MatLab, we identified twelve possible discrete mechanical states and plotted them showing where the intestine actively contracted and relaxed isometrically, auxotonically or isotonically, as well as where passive changes occurred or was quiescent. Clustering all discrete active contractions and relaxations states generated for the first time a spatio-temporal map of where enteric excitatory and inhibitory neural input to the muscle occurs during physiological movements. Recording internal diameter by an impedance probe proved equivalent to measuring external diameter, making possible to further develop similar strategy in vivo and humans.

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Mechanical properties of gastrointestinal smooth muscle

Cited by 11 publications

References 281 publications

Esophageal tone in patients with total aperistalsis: gastroesophageal reflux disease versus achalasia

Esophageal tone in patients with total aperistalsis: gastroesophageal reflux disease versus achalasia

Abnormal rectal motor physiology in patients with irritable bowel syndrome

An experimental method to identify neurogenic and myogenic active mechanical states of intestinal motility

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