Mechanical properties of oligomer-modified acrylic bone cement

Puska, Mervi; Kokkari, Anne; Närhi, Timo; Vallittu, Pekka K.

doi:10.1016/s0142-9612(02)00354-x

Cited by 62 publications

(52 citation statements)

References 23 publications

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“…To carry out biological testing, the cell culture and histological laboratory, standard stainings and molecular biology techniques should be available, as well as several light microscopes and a computer-based histomorphometric analysis system (e.g. Aho et al, 2004;Meretoja et al, 2006;Puska et al, 2003;Silva Nykänen et al, 2011).…”

Section: Methods To Study Materials For Bone Reconstructionmentioning

confidence: 99%

“…In addition, in the form of thermosets and thermoplastics, both biostable and biodegradable polymers (e.g. polycaprolactone, PCL and PMMA) have been studied, largely for tissue engineering Middleton & Tipton, 2000;Morita et al, 1998;Puska et al, 2003;Wang, 2003). Structurally, the form of these polymers can be linear, cross-linked or interpenetrated polymer networks (IPNs).…”

Section: Composites For Bone Reconstructionmentioning

confidence: 99%

“…However, PMMA-based bone cement can also be modified in the form of a semi-IPN structure by adding small amounts of cross-linking monomers (e.g. 2-30 wt% of ethylene glycol dimethacrylate, egdma) to the liquid phase (Lewis, 2009;Puska et al, 2003Puska et al, , 2004. In future tissue reconstruction applications, the acrylic polymer matrix will most probably also be modified using dendritic macromonomers.…”

Section: Chemistry Of Pmma-based Bone Cementsmentioning

confidence: 99%

“…In addition, the exothermal polymerization of MMA in vivo might cause a risk of thermal and chemical necrosis of bone. However, in most cases, PMMA-based cements have been successfully utilized in orthopaedic surgery for many decades (Lewis 2009;Puska et al, 2003). Therefore, interest has arisen in developing more biocompatible PMMA-based cements.…”

Section: Chemistry Of Pmma-based Bone Cementsmentioning

confidence: 99%

See 3 more Smart Citations

Polymer Composites for Bone Reconstruction

Puska¹,

Aho²,

Vallittu³

2011

Advances in Composite Materials - Analysis of Natural and Man-Made Materials

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Section: Methods To Study Materials For Bone Reconstructionmentioning

confidence: 99%

Section: Composites For Bone Reconstructionmentioning

confidence: 99%

Section: Chemistry Of Pmma-based Bone Cementsmentioning

confidence: 99%

Section: Chemistry Of Pmma-based Bone Cementsmentioning

confidence: 99%

See 2 more Smart Citations

Polymer Composites for Bone Reconstruction

Puska¹,

Aho²,

Vallittu³

2011

Advances in Composite Materials - Analysis of Natural and Man-Made Materials

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“…Failure of the bone/cement interface in cemented joint prostheses is the main contributor to implant loosening 15 . Furthermore, PMMA cements have a dense structure, which does not allow bone cells to grow into the cement 16 , and they show inadequate elasticity (E-module) in relation to natural bone, especially to spongiosa 17 . Calcium phosphate cements, however, show good biocompatibility and osteoconduction, but on the other hand they have inappropriate mechanical properties, low biodegradation in vivo, high brittleness, relatively long final setting times and lower flexibility than natural bone 7,18 .…”

Section: Introductionmentioning

confidence: 99%

Material properties and in vitro biocompatibility of a newly developed bone cement

Mitzner¹,

Pelt²,

Mueller³

et al. 2009

Mat. Res.

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In this study mechanical properties and biocompatibility (In Vitro) of a new bone cement were investigated. A new platform technology named COOL is a variable composite of dissolved, chemically modified PMMA and different bioceramics. COOL cures at body temperature via a classical cementation reaction. Compressive strengths ranging from 3.6 ± 0.8 to 62.8 ± 1.3 MPa and bending strengths ranging from 9.9 ± 2.4 to 26.4 ± 3.0 MPa were achieved with different COOL formulations. Porosity varied between 31 and 43%. Varying the components of each formulation mechanical properties and porosity could be adjusted. In Vitro biocompatibility studies with primary human osteoblasts (pHOB) in direct contact with different COOL formulations, did not reveal any signs of toxicity. In contrast to Refobacin ® R, cells incubated with COOL showed similar density, viability and ALP activity compared to control, if specimen were added immediately to the cell monolayer after preparation. In conclusion, COOL has promising mechanical properties in combination with high biocompatibility In Vitro and combines different advantages of both CPCs and PMMA cements by avoiding some of the respective shortcomings.

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Toughening of bone cement using nanoparticle: The effect of solvent

Misra

Kapusetti

Jaiswal

et al. 2011

J of Applied Polymer Sci

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Drawbacks of poly(methyl methacrylate) (PMMA)-based bone cement as a grouting agent for in vivo fixation of orthopedic and dental implants such as considerable low mechanical strength have been improved using nanotechnology. Bone cement-layered silicate nanocomposites have been prepared without any heat treatment in the presence of polar (dimethyl formamide, DMF) and nonpolar (benzene) solvents. Solvents have been removed completely from the bone cement after its preparation. Nanostructure is very much dependent on the solvent used for nanocomposite preparation, and benzenebased nanocomposites are highly intercalated, whereas DMF-based nanocomposites do not exhibit intercalation. Thermal stability of bone cement has improved in the presence of nanoclays. The relative enhanced interaction in case of benzene-based nanocomposites has been shown through FTIR and UV-vis studies. The significant improvement in modulus and toughness of bone cement has been demonstrated in the presence of minimum amount of nanoclay for benzene-based nanocomposites, whereas no change in modulus and reduced toughness have been observed for DMF-based nanocomposites. The decrease of contact angle has been witnessed with increasing nanoclay concentration indicating better hydrophilic materials suitable for biomedical applications for greater cell growth. The reason for varying property enhancement in different solvents has been discussed considering the polarity effect and interactions.

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Mechanical properties of oligomer-modified acrylic bone cement

Cited by 62 publications

References 23 publications

Polymer Composites for Bone Reconstruction

Polymer Composites for Bone Reconstruction

Material properties and in vitro biocompatibility of a newly developed bone cement

Toughening of bone cement using nanoparticle: The effect of solvent

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