2008
DOI: 10.1016/j.ijom.2007.12.008
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Mechanical strain induces osteogenic differentiation: Cbfa1 and Ets-1 expression in stretched rat mesenchymal stem cells

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Cited by 112 publications
(78 citation statements)
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“…Among various types of biophysical stimuli, the three individual types of stimuli selected for this study have been proven to have positive effects on osteogenic potential. [12][13][14][15][16] We hypothesized that combining these biophysical stimuli could be a more powerful method for enhancing osteogenic potential induced by each individual stimulus synergistically. 17 The developed bioreactor was able to generate and transfer both individual and combined biophysical signals using three different stimuli to cells on the 3D scaffolds.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Among various types of biophysical stimuli, the three individual types of stimuli selected for this study have been proven to have positive effects on osteogenic potential. [12][13][14][15][16] We hypothesized that combining these biophysical stimuli could be a more powerful method for enhancing osteogenic potential induced by each individual stimulus synergistically. 17 The developed bioreactor was able to generate and transfer both individual and combined biophysical signals using three different stimuli to cells on the 3D scaffolds.…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, an electromagnetic field and ultrasound are nonbiomimetic stimuli frequently used for treatment of bone fracture. Even though these stimuli are effective for enhancing osteogenic differentiation and bone formation, [12][13][14][15][16] there are still only a few articles reporting the effects of combining two or more stimuli.…”
Section: Introductionmentioning
confidence: 99%
“…In fact, although a dilatational component can always be identified for any given loading regime, many tissues of interest experience in vivo stress states that depart very substantially from purely hydrostatic pressure [Potier et al, 2010]. To drive osteogenesis, there are still numerous other forms of mechanical stimulation including but not limited to: substrate strain in uniaxial [Diederichs and van Freiberger, 2009], biaxial or equiaxial directions [Qi et al, 2008;Friedl et al, 2007] and shear stress [Stiehler et al, 2009;Kreke et al, 2008], each having been proven to contribute to new bone formation and maturation. Further research is required to know if estrogen has a synergistic effect with all types of mechanical stimulation that BMSCs encounter, or if its effects are limited to only a few forms of mechanical strain.…”
Section: Discussionmentioning
confidence: 99%
“…How to promote and accelerate the process of osteogenesis are hot spots in recent researches. Many studies have indicated that physical and chemical factors could accelerate the process of BMMSCs osteogenic differentiation, such as PEMF, mechanical stress, estrogen and so on 8,10,11) . Thus, it is necessary to seek a new factor to accelerate the process of osteogenic differentiation of BMMSCs.…”
Section: Introductionmentioning
confidence: 99%