Mechanical waves caused by collective cell migration: generation

Pajić‐Lijaković, Ivana; Milivojević, Milan

doi:10.1007/s00249-021-01581-x

Cited by 15 publications

(17 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result points to the surface rearrangement of cancer cells, as a dominant scenario (Pajic-Lijakovic and Milivojevic, 2022). This surface rearrangement becomes more intensive with an increase in the surface-to-volume ratio of the twoaggregate system, i.e., for smaller cell aggregates.…”

Section: Volumetric and Surface Cell Rearrangement During The Aggrega...mentioning

confidence: 80%

“…If the cell jamming exists, it causes the arrested coalescence (Oriola et al, 2020;Grosser et al, 2021). In this case, cells perform the volumetric rearrangement which results in: (1) a decrease in surface and volume of the two-aggregate system, (2) an increase in the cell packing density accompanied by the cell residual stress accumulated in the core region of the two-aggregate system, and (3) an increase in the neck radius (Pajic-Lijakovic and Milivojevic, 2022). The corresponding cell volumetric rearrangement during the aggregate fusion can result in a total or arrested coalescence depending on the accumulated cell stress (Oriola et al, 2020;Grosser et al, 2021;Pajic-Lijakovic and Milivojevic, 2022).…”

Section: The Fusion Of Two Cell Aggregatesmentioning

confidence: 99%

“…Otherwise, reduced surface tension, which represents a characteristic of cancer aggregates, induces cell movement from the core region of the two-aggregate system toward its surface driven by the solid stress (Kalli and Stylianopoulos, 2018). Cell movement in this case results in: (1) an increase in the volume and surface of two-aggregate systems, (2) a decrease in the cell packing density accompanied by a decrease in the compressive residual stress in the core region of the two-aggregate system, and (3) an increase in the neck radius (Pajic-Lijakovic and Milivojevic, 2022). In contrast to the rearrangement of epithelial cells, cancer cells rather perform the surface rearrangement by avoiding the transition into a jamming state (Grosser et al, 2021).…”

Section: The Fusion Of Two Cell Aggregatesmentioning

confidence: 99%

“…The fusion also induces an increase in the neck radius while the surface and volume of the twoaggregate system increase by forming an irregular ellipsoidal shape. Dechristé et al (2018) considered the fusion of two human carcinoma cell aggregates (HCT116 cell line) as a consequence of cell divisions within 70 h. The doubling time of HCT116 cells is 18 h (Gongora et al, 2008), however, the volume and surface of two-aggregate systems increase even during the first 5 h. Cancer cell divisions can be neglected within this time period, while the surface and volume changes occur primarily via CCM driven by solid stress accumulated in a core region of the two-aggregate systems (Pajic-Lijakovic and Milivojevic, 2022). The surface of two-aggregate systems increases: (1) 1.8 times for larger cancer cell aggregates (500 μm diameter) and (2) 2.3 times for smaller aggregates (300 μm diameter) within the first 5 h (Fig.…”

Section: Volumetric and Surface Cell Rearrangement During The Aggrega...mentioning

confidence: 99%

“…(1) solid stress accumulated within the aggregate core region (Kalli and Stylianopoulos, 2018), (2) tissue surface tension (Devanny et al, 2021), and (3) viscoelasticity caused by collective cell migration (CCM) (Pajic-Lijakovic and Milivojevic, 2019a;2022). In this review, we have discussed the influence of these factors on cell rearrangement studied in the model systems such as the fusion of two cell aggregates by emphasizing the difference between epithelial and cancer cells.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Surface activity of cancer cells: The fusion of two cell aggregates

Pajić‐Lijaković¹,

Milivojević²

2023

Biocell

Self Cite

View full text Add to dashboard Cite

A key feature that distinguishes cancer cells from all other cells is their capability to spread throughout the body.Although how cancer cells collectively migrate by following molecular rules which influence the state of cell-cell adhesion contacts has been comprehensively formulated, the impact of physical interactions on cell spreading remains less understood. Cumulative effects of physical interactions exist as the interplay between various physical parameters such as (1) tissue surface tension, (2) viscoelasticity caused by collective cell migration, and (3) solid stress accumulated in the cell aggregate core region. This review aims to point out the role of these physical parameters in cancer cell spreading by considering and comparing the rearrangement of various mono-cultured cancer and epithelial model systems such as the fusion of two cell aggregates. While epithelial cells undergo volumetric cell rearrangement driven by the tissue surface tension, which directs cell movement from the surface to the core region of two-aggregate systems, cancer cells rather perform surface cell rearrangement. Cancer cells migrate toward the surface of the two-aggregate system driven by the solid stress while the surface tension is significantly reduced. The solid stress, accumulated in the core region of the two-aggregate system, is capable of suppressing the movement of epithelial cells that can undergo the jamming state transition; however, this stress enhances the movement of cancer cells. We have focused here on the multi-scale rheological modeling approaches that aimed at reproducing and understanding these biological systems.

show abstract

Section: Volumetric and Surface Cell Rearrangement During The Aggrega...mentioning

confidence: 80%