Mechanical White Blood Cell Damage in Rotary Blood Pumps

Takami, Yoshiyuki; Yamane, Shingo; Makinouchi, Kenzo; Glueck, Julie; Nosé, Yukihiko

doi:10.1111/j.1525-1594.1997.tb00350.x

Cited by 27 publications

(21 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Because the new pump has no occlusive elements, the alteration of the flow pattern inside the pump due to the action of the membrane could possibly provide an explanation. Concerning changes in the WBC count and despite the fact that the decrease at 3 h ECC was not significant, a clear tendency to decrease was detected (the difference between basal and 1 h post-ECC was significant), which can be explained by the fact that WBC count is highly sensitive to ECC (9,10).…”

Section: Hematological Studymentioning

confidence: 93%

In Vivo Assessment of a New Method of Pulsatile Perfusion Based on a Centrifugal Pump

et al. 2010

View full text Add to dashboard Cite

The aim of this study was to assess platelet dysfunction and damage to organs after extracorporeal circulation using a pump based on a new method that adds a pulsatile flow to the continuous flow provided by a centrifugal pump. The continuous component of the total flow (2-3 L/min) is created by a Bio-Pump centrifugal pump, while the pulsatile component is created by the pulsating of an inner membrane pneumatically controlled by an intra-aortic counterpulsation balloon console (systolic volume of 37.5 mL in an asynchronous way with a frequency of 60 bpm). Six pigs were subjected to a partial cardiopulmonary bypass lasting 180 min and were sacrificed 60 min after extracorporeal circulation was suspended. The hematological study included the measurement of hematocrit, hemoglobin, leukocytes, and platelet function. The new pump did not significantly alter either platelet count or platelet function. In contrast, hematocrit and hemoglobin were significantly reduced during extracorporeal circulation (approximately 5% P = 0.011, and 2 g/dL P = 0.01, respectively). The leukocyte count during extracorporeal circulation showed a tendency to decrease, but this was not significant. In general, the short-term use of the new pump (4 h) did not cause any serious morphological damage to the heart, lung, kidney, or liver. The results suggest that the hemodynamic performance of the new pump is similar to a conventional centrifugal pump and could therefore be appropriate for use in extracorporeal circulation.

show abstract

Section: Hematological Studymentioning

confidence: 93%

In Vivo Assessment of a New Method of Pulsatile Perfusion Based on a Centrifugal Pump

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Due to space limitations, this is not considered further in this study. Readers wishing to gain more knowledge on this subject can take a look at for white cells or for platelets.…”

Section: Classification Of Reviewed Hemolysis Modelsmentioning

confidence: 99%

A Review of Hemolysis Prediction Models for Computational Fluid Dynamics

et al. 2017

View full text Add to dashboard Cite

Flow-induced hemolysis is a crucial issue for many biomedical applications; in particular, it is an essential issue for the development of blood-transporting devices such as left ventricular assist devices, and other types of blood pumps. In order to estimate red blood cell (RBC) damage in blood flows, many models have been proposed in the past. Most models have been validated by their respective authors. However, the accuracy and the validity range of these models remains unclear. In this work, the most established hemolysis models compatible with computational fluid dynamics of full-scale devices are described and assessed by comparing two selected reference experiments: a simple rheometric flow and a more complex hemodialytic flow through a needle. The quantitative comparisons show very large deviations concerning hemolysis predictions, depending on the model and model parameter. In light of the current results, two simple power-law models deliver the best compromise between computational efficiency and obtained accuracy. Finally, hemolysis has been computed in an axial blood pump. The reconstructed geometry of a HeartMate II shows that hemolysis occurs mainly at the tip and leading edge of the rotor blades, as well as at the leading edge of the diffusor vanes.

show abstract

“…This observation matches with observations of white blood cells in a rotary pump that suggest shear-induced damage is an integral effect over time. 26 That is, cell vitality decreases the longer cells are exposed to high shear. Experiments done by Di Carlo et al 27 to examine gene expression in cells exposed to high shear showed no significant changes.…”

confidence: 99%

Deterministic separation of cancer cells from blood at 10 mL/min

et al. 2012

View full text Add to dashboard Cite

Circulating tumor cells (CTCs) and circulating clusters of cancer and stromal cells have been identified in the blood of patients with malignant cancer and can be used as a diagnostic for disease severity, assess the efficacy of different treatment strategies and possibly determine the eventual location of metastatic invasions for possible treatment. There is thus a critical need to isolate, propagate and characterize viable CTCs and clusters of cancer cells with their associated stroma cells. Here, we present a microfluidic device for mL/min flow rate, continuous-flow capture of viable CTCs from blood using deterministic lateral displacement (DLD) arrays. We show here that a DLD array device can isolate CTCs from blood with capture efficiency greater than 85% CTCs at volumetric flow rates of up to 10 mL/min with no effect on cell viability

show abstract

Mechanical White Blood Cell Damage in Rotary Blood Pumps

Cited by 27 publications

References 10 publications

In Vivo Assessment of a New Method of Pulsatile Perfusion Based on a Centrifugal Pump

In Vivo Assessment of a New Method of Pulsatile Perfusion Based on a Centrifugal Pump

A Review of Hemolysis Prediction Models for Computational Fluid Dynamics

Deterministic separation of cancer cells from blood at 10 mL/min

Contact Info

Product

Resources

About