Mechanically active adhesive and immune regulative dressings for wound closure

Hu, Jiaying; Wei, Ting; Zhao, He; Chen, Muchao; Tan, Yanjun; Ji, Zhaoxin; Jin, Qiutong; Shen, Jingjing; Han, Yikai; Yang, Nailin; Chen, Linfu; Xiao, Zhisheng; Zhang, Han; Liu, Zhuang; Chen, Qian

doi:10.1016/j.matt.2021.06.044

Cited by 79 publications

(47 citation statements)

References 48 publications

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“…In the early stages of wound healing, the transition from the inflammatory stage to the proliferative stage was accelerated by MN x sutures, with granulation tissues observed in the treatment groups, indicating MN x can competently mediate a beneficial wound healing process (Supplementary Fig. 51 ) 59 , 60 . Accordingly, we further investigated the effects of MN x sutures on oxidative stress and inflammation in TBI.…”

Section: Resultsmentioning

confidence: 98%

“…As shown in the schematic wound closure process (Fig. 6a ), scalp injuries from brain trauma are physiologically complex, accompanied by complicated and dynamic interactions strongly associated with time, and can continuously trigger a cascade of molecular and biochemical events in vivo, resulting in severe inflammation and oxidative stress 59 , 61 . Typically, the scalp injuries with PGA sutures only recovered slowly from the inflammatory phase to the tissue modeling.…”

Section: Discussionmentioning

confidence: 99%

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Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma

et al. 2022

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Regenerable nanozymes with high catalytic stability and sustainability are promising substitutes for naturally-occurring enzymes but are limited by insufficient and non-selective catalytic activities. Herein, we developed single-atom nanozymes of RhN4, VN4, and Fe-Cu-N6 with catalytic activities surpassing natural enzymes. Notably, Rh/VN4 preferably forms an Rh/V-O-N4 active center to decrease reaction energy barriers and mediates a “two-sided oxygen-linked” reaction path, showing 4 and 5-fold higher affinities in peroxidase-like activity than the FeN4 and natural horseradish peroxidase. Furthermore, RhN4 presents a 20-fold improved affinity in the catalase-like activity compared to the natural catalase; Fe-Cu-N6 displays selectivity towards the superoxide dismutase-like activity; VN4 favors a 7-fold higher glutathione peroxidase-like activity than the natural glutathione peroxidase. Bioactive sutures with Rh/VN4 show recyclable catalytic features without apparent decay in 1 month and accelerate the scalp healing from brain trauma by promoting the vascular endothelial growth factor, regulating the immune cells like macrophages, and diminishing inflammation.

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Section: Resultsmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma

et al. 2022

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“…For comparison, the epidermis was utterly absent in the BC-C group. Our electromechanical synergistic system rapidly achieved over 96% closure rate and superb reepithelialization effect within 8 days, which obviously exceeded other reported mechanical regulation or electric stimulation approaches based on similar rat models ( 48 – 52 ) (Fig. 5E).…”

Section: Discussionmentioning

confidence: 56%

“…( D ) H&E stains of skin at the wound site. ( E ) Wound closure rate of the EMSD-C compared to the reported results by the mechanical regulation or electric stimulation (mechanical contraction parameters, voltage, and frequency) ( 48 – 52 ). Mechanical regulation and electric stimulation are represented by M and E, respectively.…”

Section: Discussionmentioning

confidence: 99%

A programmable and skin temperature–activated electromechanical synergistic dressing for effective wound healing

Yao

Yin

et al. 2022

Sci. Adv.

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Mechanical regulation and electric stimulation hold great promise in skin tissue engineering for manipulating wound healing. However, the complexity of equipment operation and stimulation implementation remains an ongoing challenge in clinical applications. Here, we propose a programmable and skin temperature–activated electromechanical synergistic wound dressing composed of a shape memory alloy-based mechanical metamaterial for wound contraction and an antibacterial electret thin film for electric field generation. This strategy is successfully demonstrated on rats to achieve effective wound healing in as short as 4 and 8 days for linear and circular wounds, respectively, with a statistically significant over 50% improvement in wound closure rate versus the blank control group. The optimally designed electromechanical synergistic stimulation could regulate the wound microenvironment to accelerate healing metabolism, promote wound closure, and inhibit infection. This work provided an effective wound healing strategy in the context of a programmable temperature-responsive, battery-free electromechanical synergistic biomedical device.

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“…Different from the introduction of various drugs or cells into hydrogels to passively promote wound healing, these exogenous signals can directly and actively regulate the behaviors of fibroblasts, keratinocytes, and epithelial cells, modulating the cell behavior to promote wound healing. In one study, the main network of poly ( N -isopropyl acrylamide) hydrogels were formed by free radical polymerization of N -isopropyl acrylamide, a temperature-sensitive monomer, while the semi-crosslinked network was further formed by introducing poly (methacrylic acid) ( Hu et al, 2021 ). The hydrogel could effectively accelerate wound healing in mouse and pig models by promoting angiogenesis, collagen deposition and reducing inflammation through the strong adhesion to tissue and mechanical contraction of the wound.…”

Section: Functionalization Of Hydrogels For Wound Healingmentioning

confidence: 99%

Rational Design and Preparation of Functional Hydrogels for Skin Wound Healing

et al. 2022

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Skin wound healing often contains a series of dynamic and complex physiological healing processes. It is a great clinical challenge to effectively treat the cutaneous wound and regenerate the damaged skin. Hydrogels have shown great promise for skin wound healing through the rational design and preparation to endow with specific functionalities. In the mini review, we firstly introduce the design and construction of various types of hydrogels based on their bonding chemistry during cross-linking. Then, we summarize the recent research progress on the functionalization of bioactive hydrogel dressings for skin wound healing, including anti-bacteria, anti-inflammatory, tissue proliferation and remodeling. In addition, we highlight the design strategies of responsive hydrogels to external physical stimuli. Ultimately, we provide perspectives on future directions and challenges of functional hydrogels for skin wound healing.

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Mechanically active adhesive and immune regulative dressings for wound closure

Cited by 79 publications

References 48 publications

Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma

Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma

A programmable and skin temperature–activated electromechanical synergistic dressing for effective wound healing

Rational Design and Preparation of Functional Hydrogels for Skin Wound Healing

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