Mechanically reinforced injectable bioactive nanocomposite hydrogels for in-situ bone regeneration

Yu, Xingge; Wang, Xiuhui; Li, Dejian; Sheng, Ruilong; Qian, Yong; Zhu, Rui; Wang, Xudong; Lin, Kaili

doi:10.1016/j.cej.2021.132799

Cited by 84 publications

(47 citation statements)

References 52 publications

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“…Because of their biocompatible properties and tunable physical characteristics, GelMA hydrogels hold great promise in biomedical applications including tissue repair and regeneration, 36 drug delivery, 37 and wearable biosensing. 38 Since pure GelMA hydrogels are extremely weak and fragile, they are rarely used alone and are commonly combined with other components to increase the mechanical strength 39,40 and/or endow new biological functions. 41,42 Hydrogels have a wide range of applications in drug delivery.…”

Section: Resultsmentioning

confidence: 99%

Mechanoresponsive Drug Loading System with Tunable Host–Guest Interactions for Ocular Disease Treatment

Zhao

Wang

et al. 2022

ACS Biomater. Sci. Eng.

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Conventional administration of eye drops often requires high dosages and/or repetitive treatments to achieve therapeutic efficacy. This is inefficient and may result in side effects or even toxicity. Although many delivery systems of ophthalmic drugs have been reported, most of them work in a fixed format in which both the type and dose of the loaded drugs cannot be changed upon demand. To overcome this limitation, a hybrid double network hydrogel system composed of methacryloyl gelatin, pluronic F127 diacrylate, and β-cyclodextrin-modified oxidized dextran was developed. The hydrogels presented good mechanical strength and biocompatibility. In vitro assessments demonstrated that the hydrogels loaded with commonly used ophthalmic drugs could sustain the drug release for more than 21 days. This hydrogel system exhibited features of mechanoresponsive drug loading, and the capacity of drug loading could be significantly enhanced by macroscopically mechanical compression. Further in vivo evaluation of the drug delivery capacity showed that a dexamethasone-loaded hydrogel as a fornix insert effectively suppressed upregulation of proangiogenic factors and suture-induced corneal neovascularization in rats. This novel hydrogel system represents a promising drug delivery platform, which could potentially improve the treatments of ocular surface and other diseases.

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Section: Resultsmentioning

confidence: 99%

Mechanoresponsive Drug Loading System with Tunable Host–Guest Interactions for Ocular Disease Treatment

Zhao

Wang

et al. 2022

ACS Biomater. Sci. Eng.

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“…BMP-2 has an important role in activate osteoblasts and promote bone formation ( Wang et al, 2021 ). OCN influences late differentiation of osteoblasts, which mainly occurs in the mineralization stage ( Wan et al, 2022 ; Yu et al, 2022 ). In vitro RT-PCR analysis showed that the expression levels of these genes in cells cultured on AHT-Sr were significantly higher than those cultured on AHT.…”

Section: Discussionmentioning

confidence: 99%

Strontium-doping promotes bone bonding of titanium implants in osteoporotic microenvironment

Geng

Wang

Lin

et al. 2022

Front. Bioeng. Biotechnol.

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Osteoporosis is a major challenge to oral implants, and this study focused on improving the osseointegration ability of titanium (Ti) implants in osteoporosis environment via surface modification, including doping of strontium ion and preparation of nanoscale surface feature. Our previous studies have shown that strontium (Sr) ions can enhance osteogenic activity. Therefore, we aimed to comprehensively evaluate the effect of hydrothermal treatment of Sr-doped titanium implant coating on bone-binding properties in the microenvironment of osteoporosis in this study. We fabricated Sr-doped nanocoating (AHT-Sr) onto the surface of titanium implants via hydrothermal reaction. The rough Sr-doping had good biological functions and could apparently promote osteogenic differentiation of osteoporotic bone marrow mesenchymal stem cells (OVX-BMSCs). Most importantly, AHT-Sr significantly promoted bone integration in the osteoporosis environment. This study provides an effective approach to implant surface modification for better osseointegration in an osteoporotic environment.

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“…Sprague–Dawley (SD) rats (2 weeks old) were purchased from Shanghai Sippr-BK Laboratory Animal Co. Ltd. (China). Bone marrow stem cells (BMSCs) were extracted from the femur and tibia of the rats as previously reported [ 30 ]. Then, the BMSCs were cultured in α-minimum essential medium (α-MEM, Gibco, USA) supplemented with 10% FBS (Gibco, USA) and 1% penicillin–streptomycin (Gibco, USA).…”

Section: Methodsmentioning

confidence: 99%

In situ construction of flower-like nanostructured calcium silicate bioceramics for enhancing bone regeneration mediated via FAK/p38 signaling pathway

et al. 2022

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Background The repair of tissue defects has attracted considerable attention and remained a substantial challenge. Calcium silicate (CaSiO3, CS) bioceramics have attracted the interest of researchers due to their excellent biodegradability. Recent studies have demonstrated that nanoscale-modified bioactive materials with favorable biodegradability could promote bone tissue regeneration, providing an alternative approach for the repair of bone defects. However, the direct construction of biodegradable nanostructures in situ on CS bioceramics was still difficult. Results In this study, flower-like nanostructures were flexibly prepared in situ on biodegradable CS bioceramics via hydrothermal treatment. The flower-like nanostructure surfaces exhibited better hydrophilicity and more significantly stimulated cell adhesion, alkaline phosphatase (ALP) activity, and osteogenic differentiation. Furthermore, the CS bioceramics with flower-like nanostructures effectively promoted bone regeneration and were gradually replaced with newly formed bone due to the favorable biodegradability of these CS bioceramics. Importantly, we revealed an osteogenesis-related mechanism by which the FAK/p38 signaling pathway could be involved in the regulation of bone mesenchymal stem cell (BMSC) osteogenesis by the flower-like nanostructure surfaces. Conclusions Flower-like nanostructure surfaces on CS bioceramics exerted a strong effect on promoting bone repair and regeneration, suggesting their excellent potential as bone implant candidates for improving bone regeneration. Graphical Abstract

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Mechanically reinforced injectable bioactive nanocomposite hydrogels for in-situ bone regeneration

Cited by 84 publications

References 52 publications

Mechanoresponsive Drug Loading System with Tunable Host–Guest Interactions for Ocular Disease Treatment

Mechanoresponsive Drug Loading System with Tunable Host–Guest Interactions for Ocular Disease Treatment

Strontium-doping promotes bone bonding of titanium implants in osteoporotic microenvironment

In situ construction of flower-like nanostructured calcium silicate bioceramics for enhancing bone regeneration mediated via FAK/p38 signaling pathway

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