Mechanically Tunable Hollow Silica Ultrathin Nanoshells for Ultrasound Contrast Agents

Liberman, Alexander; Wang, James; Lü, Ning; Viveros, Robert D.; Allen, Chuck; Mattrey, Robert F.; Blair, Sarah L.; Trogler, William C.; Kim, M. J.; Kummel, Andrew C.

doi:10.1002/adfm.201500610

Cited by 49 publications

(56 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This phenomenon is typically used for ultrasound‐based diagnostic imaging. As a widely employed diagnostic‐imaging modality clinically, US imaging is featured with real‐time observation, noninvasiveness, high efficiency, low cost and high safety . In addition to typical imaging capability, US also has found broad therapeutic applications, such as US‐triggered drug releasing and focused ultrasound‐induced hyperthermia (Figure ) .…”

Section: Introductionmentioning

confidence: 99%

Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

2016

View full text Add to dashboard Cite

The fast development of photoactivation for cancer treatment provides an efficient photo-therapeutic strategy for cancer treatment, but traditional photodynamic or photothermal therapy suffers from the critical issue of low in vivo penetration depth of tissues. As a non-invasive therapeutic modality, sonodynamic therapy (SDT) can break the depth barrier of photoactivation because ultrasound has an intrinsically high tissue-penetration performance. Micro/nanoparticles can efficiently augment the SDT efficiency based on nanobiotechnology. The state-of-art of the representative achievements on micro/nanoparticle-enhanced SDT is summarized, and specific functions of micro/nanoparticles for SDT are discussed, from the different viewpoints of ultrasound medicine, material science and nanobiotechnology. Emphasis is put on the relationship of structure/composition-SDT performance of micro/nanoparticle-based sonosensitizers. Three types of micro/nanoparticle-augmented SDT are discussed, including organic and inorganic sonosensitizers and micro/nanoparticle-based but sonosensitizer-free strategies to enhance the SDT outcome. SDT-based synergistic cancer therapy augmented by micro/nanoparticles and their biosafety are also included. Some urgent critical issues and potential developments of micro/nanoparticle-augmented SDT for efficient cancer treatment are addressed. It is highly expected that micro/nanoparticle-augmented SDT will be quickly developed as a new and efficient therapeutic modality which will find practical applications in cancer treatment. At the same time, fundamental disciplines regarding materials science, chemistry, medicine and nanotechnology will be advanced.

show abstract

Section: Introductionmentioning

confidence: 99%

Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

2016

View full text Add to dashboard Cite

show abstract

“…15,1617 The hollow silica NS are subjected to at least three cycles of vacuum desorption followed by perfluoropentane filling. The perfluoropentane gas filled NS are suspended in degassed water at a concentration of 4 mg/ml…”

Section: Methodsmentioning

confidence: 99%

Utilization of iron (III)-doped nanoshells for in vivo marking of nonpalpable tumors using a VX2 rabbit model

Ward

Wang

Mendez

et al. 2016

The American Journal of Surgery

Self Cite

View full text Add to dashboard Cite

INTRODUCTION We aimed to evaluate the potential for ultrasound (US) visible biodegradable nanoshells (NS) as an alternative to wire guided localization (WL) for non-palpable tumors in vivo. METHODS VX2 tumor was injected in bilateral thighs of 22 New Zealand rabbits and after 5-10 days one tumor was marked with a wire as a control and the contralateral tumor was injected with 1mL of 500 nm gas-filled silica NS under Doppler US. Tumors were excised after 24 hours. Chi square was utilized for significance, p=.05. RESULTS One rabbit was excluded on postoperative day 1 due to equipment failure, no ill effects were observed from the NS. The NS were utilized to localize and resect 100% of marked tissue, 4/21 wires were displaced (p<.05) . CONCLUSIONS We have shown that preoperatively injected US visible silica NS can be successfully utilized to mark non-palpable tumors in vivo more consistently than WL.

show abstract

“…Milli-Q purified water was obtained from a Millipore SuperQ Plus Water Purification System (Billerica, MA). The 2-lm microshells used in this study were synthesized with methods previously developed by Liberman et al 27 To visualize transition of the particles, an MR contrast agent, Gd 2 O 3 , was incorporated into the PFP liquid. Gadolinium oxide nanoparticles (2-nm diameter) were manufactured following a modified polyol method.…”

Section: A Ultrasound Phase-shift Emulsion Formulationmentioning

confidence: 99%

“…Silica‐shell ultrasound‐triggered phase‐shift emulsions (sUPEs) can be transitioned to microbubbles to enhance the effects of therapeutic ultrasound and act as multimodality contrast agents . sUPEs also exhibit increased stability and longevity in vivo compared with microbubbles or other nanoparticle formulations . Transition of sUPEs containing MR contrast agents may increase MR image intensity for clearer delineation of the ablation zone .…”

Section: Introductionmentioning

confidence: 99%

“…22,23,25 sUPEs also exhibit increased stability and longevity in vivo compared with microbubbles or other nanoparticle formulations. 21,22,[25][26][27] Transition of sUPEs containing MR contrast agents may increase MR image intensity for clearer delineation of the ablation zone. 28 Furthermore, bubble-enhanced heating has been demonstrated via droplet transition.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

MRI‐guided transurethral insonation of silica‐shell phase‐shift emulsions in the prostate with an advanced navigation platform

et al. 2018

Self Cite

View full text Add to dashboard Cite

Purpose In this study, the efficacy of transurethral prostate ablation in the presence of silica‐shell ultrasound‐triggered phase‐shift emulsions (sUPEs) doped with MR contrast was evaluated. The influence of sUPEs on MR imaging assessment of the ablation zone was also investigated. Methods sUPEs were doped with a magnetic resonance (MR) contrast agent, Gd2O3, to assess ultrasound transition. Injections of saline (sham), saline and sUPEs alone, and saline and sUPEs with Optison microbubbles were performed under guidance of a prototype interventional MRI navigation platform in a healthy canine prostate. Treatment arms were evaluated for differences in lesion size, T1 contrast, and temperature. In addition, non‐perfused areas (NPAs) on dynamic contrast‐enhanced (DCE) MRI, 55°C isotherms, and areas of 240 cumulative equivalent minutes at 43°C (CEM43) dose or greater computed from MR thermometry were measured and correlated with ablated areas indicated by histology. Results For treatment arms including sUPEs, the computed correlation coefficients between the histological ablation zone and the NPA, 55°C isotherm, and 240 CEM43 area ranged from 0.96–0.99, 0.98–0.99, and 0.91–0.99, respectively. In the absence of sUPEs, the computed correlation coefficients between the histological ablation zone and the NPA, 55°C isotherm, and 240 CEM43 area were 0.69, 0.54, and 0.50, respectively. Across all treatment arms, the areas of thermal tissue damage and NPAs were not significantly different (P = 0.47). Areas denoted by 55°C isotherms and 240 CEM43 dose boundaries were significantly larger than the areas of thermal damage, again for all treatment arms (P = 0.009 and 0.003, respectively). No significant differences in lesion size, T1 contrast, or temperature were observed between any of the treatment arms (P > 0.0167). Lesions exhibiting thermal fixation on histological analysis were present in six of nine insonations involving sUPE injections and one of five insonations involving saline sham injections. Significantly larger areas (P = 0.002), higher temperatures (P = 0.004), and more frequent ring patterns of restricted diffusion on ex vivo diffusion‐weighted imaging (P = 0.005) were apparent in lesions with thermal fixation. Conclusions T1 contrast suggesting sUPE transition was not evident in sUPE treatment arms. The use of MR imaging metrics to predict prostate ablation was not diminished by the presence of sUPEs. Lesions generated in the presence of sUPEs exhibited more frequent thermal fixation, though there were no significant changes in the ablation areas when comparing arms with and without sUPEs. Thermal fixation corresponded to some qualitative imaging features.

show abstract

Mechanically Tunable Hollow Silica Ultrathin Nanoshells for Ultrasound Contrast Agents

Cited by 49 publications

References 44 publications

Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

Utilization of iron (III)-doped nanoshells for in vivo marking of nonpalpable tumors using a VX2 rabbit model

MRI‐guided transurethral insonation of silica‐shell phase‐shift emulsions in the prostate with an advanced navigation platform

Contact Info

Product

Resources

About