Mechanism and Kinetics of Punch Sticking of Pharmaceuticals

Paul, Shubhajit; Taylor, Lisa J.; Murphy, Brendan; Krzyzaniak, Joseph F.; Dawson, Neil; Mullarney, Matthew P.; Meenan, Paul; Sun, Changquan Calvin

doi:10.1016/j.xphs.2016.07.015

Cited by 57 publications

(49 citation statements)

References 35 publications

(35 reference statements)

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“…Many attempts in the literature have been made to determine the elusive root cause of this phenomenon however no single root cause has been identified [7,8]. It is known that sticking may be due to API adherence even when it is present in a formulation at low concentrations [9] and many complex processing and environmental mechanisms such as speed/force/dwell time [10], temperature/humidity [11], punch geometry/quality where quality is defined as surface roughness and if the punch contains any defects [10] and lubrication [12] have been shown to contribute.…”

Section: Introductionmentioning

confidence: 99%

Effects of crystal habit on the sticking propensity of ibuprofen—A case study

Hooper

Clarke

Docherty

et al. 2017

International Journal of Pharmaceutics

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This study demonstrates the effect of active pharmaceutical ingredient (API) particle habit on the sticking propensity of ibuprofen. Four diverse crystal habits with similar physico chemical properties are reported and the sticking propensity was found to increase with shape regularity. The surface energy of the extreme habits were shown to be different where particles that were more regular in shape exhibited surface energies of 9mJ/m higher than those that were needle-like in habit. Computational and experimental data reveals that the increase in surface energy of the regular shaped particles can be attributed to the increase in the specific (polar) component, which is due to greater presence of faces which contain the carboxylic acid functionality at the surface. The increase in the specific energy component is shown to correlate with the sticking propensity of ibuprofen. It is proposed that investigation of the chemical causality of sticking, for this API and others, using the techniques demonstrated in this paper will be of increasing importance.

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Section: Introductionmentioning

confidence: 99%

Effects of crystal habit on the sticking propensity of ibuprofen—A case study

Hooper

Clarke

Docherty

et al. 2017

International Journal of Pharmaceutics

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“…remarkably decreased owing to the efficient coating layer, making the surface of the acidic granules more prone to the PVP's surface. 27,28 Such an efficient surface coating was conrmed by the SEM and surface element analysis data ( Fig. 2 and Table 3).…”

Section: Sticking Propensity During Tabletingmentioning

confidence: 87%

Improvements in sticking, hygroscopicity, and compactibility of effervescent systems by fluid-bed coating

Zheng

Yang

et al. 2019

RSC Adv.

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“…IBU has a high tendency to stick and adhere to tablet press punches and die cavity walls. The sticking properties of APIs can be affected by temperature during compaction, humidity, degree of lubrication, melting point of the API, particle size, excipient type and grade, and surface roughness of tablet press tooling surface (Paul et al, 2017). A high force of ejection due to powder sticking problems can slow down the tablet manufacturing process speed.…”

Section: Compactability and Tensile Strength Of Ibu Powders And Tabletsmentioning

confidence: 99%

Modelling and understanding powder flow properties and compactability of selected active pharmaceutical ingredients, excipients and physical mixtures from critical material properties

Worku

Kumar

Gomes

et al. 2017

International Journal of Pharmaceutics

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The development of solid dosage forms and manufacturing processes are governed by complex physical properties of the powder and the type of pharmaceutical unit operation the manufacturing processes employs. Suitable powder flow properties and compactability are crucial bulk level properties for tablet manufacturing by direct compression. It is also generally agreed that small scale powder flow measurements can be useful to predict large scale production failure. In this study, predictive multilinear regression models were effectively developed from critical material properties to estimate static powder flow parameters from particle size distribution data for a single component and for binary systems. A multilinear regression model, which was successfully developed for ibuprofen, also efficiently predicted the powder flow properties for a range of batches of two other active pharmaceutical ingredients processed by the same manufacturing route. The particle size distribution also affected the compactability of ibuprofen, and the scope of this work will be extended to the development of predictive multivariate models for compactability, in a similar manner to the approach successfully applied to flow properties.

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Mechanism and Kinetics of Punch Sticking of Pharmaceuticals

Cited by 57 publications

References 35 publications

Effects of crystal habit on the sticking propensity of ibuprofen—A case study

Effects of crystal habit on the sticking propensity of ibuprofen—A case study

Improvements in sticking, hygroscopicity, and compactibility of effervescent systems by fluid-bed coating

Modelling and understanding powder flow properties and compactability of selected active pharmaceutical ingredients, excipients and physical mixtures from critical material properties

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