Mechanism of O2-sensitive red cell properties

Gibson, John S.

doi:10.1182/blood-2016-10-743898

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…The study by Reiner et al showed that ticagrelor may reduce the activity of PAI-1 [22]. Ticagrelor blocks platelet P2Y 12 receptors, inhibits platelet activation, and, finally, aggregation through binding α2β3 receptors, which bind fibrinogen [23]. In addition, the study by Gasecka et al showed that ticagrelor may reduce the release of extracellular vesicles (EVs) [24].…”

Section: Introductionmentioning

confidence: 99%

Factors Determining Ticagrelor-Induced Dyspnea in Patients with Acute Coronary Syndrome

et al. 2022

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(1) Background: The aim of this study was to determine clinical and genetic factors predicting the development of dyspnea in patients receiving ticagrelor. (2) Methods: A total of 277 patients with acute myocardial infarction (with and without ST-segment elevation), who underwent coronary angiography and PTCA with stent implantation and treated with antiplatelet drugs (ticagrelor and aspirin), were enrolled in this study. Platelet aggregation (induction with high-sensitivity ADP, ADP HS) testing was performed using a MULTIPLATE analyzer and reagents for the determination of P2Y12 receptor activity. Venous blood samples were collected for genotyping. (3) Results: Patients experiencing ticagrelor-related dyspnea had lower ADP HS. ROC curve analysis showed that an ADP HS cut-off of ≤19.5 U was associated with the development of dyspnea. The ADP HS value of ≤19.5 U and any dose of atorvastatin lower than 80 mg (or no atorvastatin) increased the risk of dyspnea by more than 4 and 2 times, respectively (OR = 4.07, p ≤ 0.001 and OR = 2.25; p = 0.008). (4) Conclusion: A lower ADP HS value possibly indicates greater ticagrelor activity and a higher plasma concentration of this drug. Atorvastatin might have an impact on the occurrence of ticagrelor-related dyspnea by affecting ticagrelor metabolism. No impact of any genetic variant on the development of dyspnea was determined.

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Section: Introductionmentioning

confidence: 99%

Factors Determining Ticagrelor-Induced Dyspnea in Patients with Acute Coronary Syndrome

et al. 2022

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“…Thus, the Hb molecule can be combined with semiconductor materials to promote CO 2 capture. As ZnO has interesting surface properties, which drive the many applications mentioned before, it is a great candidate to serve as a base to be linked with Hb [22]. Even though ZnO has been functionalized with many molecules in other studies that focused on CO 2 capture (such as benzimidazole-based ionic liquid [23], carbon nitride [24], and multiwalled carbon nanotubes and SiO 2 [25]), finding accessible methodologies for achieving a commercial device is a current need [26].…”

Section: Introductionmentioning

confidence: 99%

Influence of ZnO Morphology on the Functionalization Efficiency of Nanostructured Arrays with Hemoglobin for CO2 Capture

et al. 2022

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In this study, nanostructured ZnO arrays were synthesized by an accessible thermal oxidation (TO) methodology. The Zn films were chemically etched with nitric acid (HNO3) and then oxidized in a furnace at 500 °C for 5 h. Two different morphologies were achieved by modifying the HNO3 concentration in the etching process: (a) ZnO grass-like nanostructures and (b) rod-like nanostructures, with an etching process in HNO3 solution at 2 and 8 M concentration, respectively. The physical and chemical properties of the samples were analyzed by X-ray diffraction (XRD), scanning (SEM) and transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDS), and Raman spectroscopy. Both morphologies were functionalized with hemoglobin, and a difference was found in the efficiency of functionalization, which was monitored by UV–Vis spectroscopy. The sample with the highest efficiency was the ZnO grass-like nanostructures. Afterward, the capture of carbon dioxide was evaluated by monitoring a sodium carbonate solution interacting with the as-functionalized samples. The evaluation was analyzed by UV–Vis spectroscopy and the results showed a CO2 capture of 98.3% and 54% in 180 min for the ZnO grass-like and rod-like nanostructures, respectively.

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CHIP, ICUS, CCUS and other four-letter words

Bejar

2017

Leukemia

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Clonal hematopoiesis can be identified by the presence of somatic mutations in blood or bone marrow even in individuals without a myeloid malignancy. Advances in DNA sequencing have led to the discovery that clonal hematopoiesis is remarkably common and occurs in a wide variety of settings, each often described by unique acronym. These distinctions can be useful as the implications of clonal hematopoiesis depend almost entirely on the clinical context in which it is identified. However, some generalizations can be made. The prevalence of clonal hematopoiesis increases with age, particularly after the fifth decade of life. Clonal hematopoiesis in normal individuals with very small clones is typically benign, while patients with clinically abnormal hematopoiesis, larger clones and more driver gene mutations appear to be at much greater risk. Understanding the significance of clonal hematopoiesis in the various contexts in which it occurs can influence how physicians assess risk, select therapies and counsel their patients. This concise review examines the implications of clonal hematopoiesis in several settings, including normal aging, aplastic anemia, unexplained cytopenias and patients receiving cytotoxic chemotherapy.

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Mechanism of O2-sensitive red cell properties

Cited by 4 publications

References 10 publications

Factors Determining Ticagrelor-Induced Dyspnea in Patients with Acute Coronary Syndrome

Factors Determining Ticagrelor-Induced Dyspnea in Patients with Acute Coronary Syndrome

Influence of ZnO Morphology on the Functionalization Efficiency of Nanostructured Arrays with Hemoglobin for CO2 Capture

CHIP, ICUS, CCUS and other four-letter words

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