Mechanisms involved in eosinophil migration. Platelet-activating factor-induced Chemotaxis and interleukin-5-induced chemokinesis are mediated by different signals

Schweizer, René C.; Kessel-Welmers, Berris A. C. van; Warringa, R. A. J.; Maikoe, Tjander; Raaijmakers, J. A. M.; Lammers, Jan-Willem; Koenderman, Leo

doi:10.1002/jlb.59.3.347

Cited by 57 publications

(44 citation statements)

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“…For example, the urokinase plasminogen activator (uPA)/plasminogen have been implicated in the extravasation of T cells and the uPA receptor was identified as a Tlymphocyte activation antigen (34). A variety of agonists (35)(36)(37) induce uPA-dependent plasminogen activation of eosinophils. Also, inhibition of uPA, MMPs, or Plg/plasmin decreases in vitro eosinophil adhesion (38) or transmigration (12,37).…”

Section: Discussionmentioning

confidence: 99%

Plasminogen Is an Important Regulator in the Pathogenesis of a Murine Model of Asthma

Swaisgood¹,

Aronica²,

Swaidani³

et al. 2007

Am J Respir Crit Care Med

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Section: Discussionmentioning

confidence: 99%

Plasminogen Is an Important Regulator in the Pathogenesis of a Murine Model of Asthma

Swaisgood¹,

Aronica²,

Swaidani³

et al. 2007

Am J Respir Crit Care Med

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“…One putative principle involved in the priming of eosinophils is interleukin (IL)-5, as has been demonstrated in vitro and in vivo for bronchial asthma (20).…”

Section: Discussionmentioning

confidence: 99%

Major basic protein, but not eosinophil cationic protein or eosinophil protein X, is related to atopy in cystic fibrosis

Koller

Halmerbauer

Müller

et al. 1999

Allergy

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Increased eosinophil granule proteins have been described in serum and sputum samples of patients with cystic fibrosis (CF). It has been assumed that eosinophil degranulation is enhanced in atopic subjects – as in asthmatics. Since in CF no differences in eosinophil cationic protein (ECP), eosinophil protein X (EPX), and eosinophil peroxidase between atopic and nonatopic subjects have been detected, we investigated whether major basic protein (MBP) is increased in serum and sputum samples derived from atopic (n=14) compared with nonatopic CF subjects (n=26). In CF patients, high mean serum (sputum) levels of ECP 29.7 μg/l (2.7 mg/l), EPX 53.7 μg/l (7.9 mg/l), and MBP 984.6 μg/l but low sputum MBP levels (57.4 μg/l) were measured. In addition, in serum and in sputum samples, a significant correlation between MBP and ECP (P<0.03 and P<0.0001, respectively) or EPX (P<0.05 and P<0.0004, respectively) was detected. By subdivision of the patients into allergic and nonallergic subjects, significant differences were found for serum MBP values only (mean 1382.2 μg/l vs 770.5 μg/l; P<0.0001), but not for ECP or EPX serum levels or for eosinophil proteins in sputum. Although no differences between atopic and nonatopic CF patients in ECP and EPX were found, serum MBP levels were higher in patients sensitized to inhalant allergens than in nonsensitized subjects. These results indicate differential release of eosinophil granule proteins in peripheral blood from eosinophils, and they also indicate that MBP in serum likely is to be a better discriminator of atopy in CF.

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“…HUVECs were isolated from human umbilical cord veins as described previously [29]. The cells were cultured in endothelial cell growth medium-2 (Lonza, Walkersville, MD, USA).…”

Section: Huvec Culture and Stimulationmentioning

confidence: 99%

Steroids induce a disequilibrium of secreted interleukin-1 receptor antagonist and interleukin-1β synthesis by human neutrophils

Langereis

Oudijk²,

Schweizer³

et al. 2010

Eur Respir J

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Chronic obstructive pulmonary disease (COPD) is characterised by neutrophilic inflammation in the airways and these neutrophils contribute to the production of inflammatory mediators. Dampening the production of proinflammatory mediators might be an important strategy to treat COPD and glucocorticosteroids are known to do so via inhibition of nuclear factor-kB. However, this pathway is important for the control of pro-and anti-inflammatory genes.We studied the effects of dexamethasone on production and secretion of pro-inflammatory interleukin (IL)-1b and anti-inflammatory secreted IL-1 receptor antagonist (sIL-1Ra) by human neutrophils activated with tumor necrosis factor (TNF)-a.In vitro, TNF-a-stimulated neutrophils produced significant amounts of IL-1b and sIL-1Ra; this production was inhibited by dexamethasone. However, synthesis and secretion of sIL-1Ra was inhibited at lower concentrations dexamethasone compared to IL-1b, which changed the IL-1b:sIL1Ra ratio significantly. This altered ratio resulted in a more pro-inflammatory condition, as visualised by increased intercellular adhesion molecule-1 expression on human endothelial cells. In vivo, moderate-to-severe COPD patients using inhaled glucocorticosteroids have decreased plasma sILRa levels compared with mild-to-moderate patients not on glucocorticosteroid treatment.In conclusion, dexamethasone induces a pro-inflammatory shift in the IL-1b:sIL-1Ra cytokine balance in neutrophils in vitro, which might contribute to a lack of endogenous anti-inflammatory signals to dampen inflammation in vivo.

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Mechanisms involved in eosinophil migration. Platelet-activating factor-induced Chemotaxis and interleukin-5-induced chemokinesis are mediated by different signals

Cited by 57 publications

References 0 publications

Plasminogen Is an Important Regulator in the Pathogenesis of a Murine Model of Asthma

Plasminogen Is an Important Regulator in the Pathogenesis of a Murine Model of Asthma

Major basic protein, but not eosinophil cationic protein or eosinophil protein X, is related to atopy in cystic fibrosis

Steroids induce a disequilibrium of secreted interleukin-1 receptor antagonist and interleukin-1β synthesis by human neutrophils

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