Mechanisms Involved in the Development of Chemotherapy-Induced Neuropathy

Boyette-Davis, Jessica A.; Walters, Edgar T.; Dougherty, Patrick M.

doi:10.2217/pmt.15.19

Cited by 146 publications

(126 citation statements)

References 129 publications

(142 reference statements)

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“…These effects can negatively influence neuronal and glial cell phenotypes which may contribute to the development of CIPN, thus hindering the understanding of specific mechanism underlying this side effect. [4] A recent review by Boyette-Davis et al . [4] identified a number of different mechanisms of actions for CIPN [Table 1].…”

Section: Resultsmentioning

confidence: 99%

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New Insights into Potential Prevention and Management Options for Chemotherapy-Induced Peripheral Neuropathy

Schloss

Colosimo

Vitetta

2016

Asia-Pacific Journal of Oncology Nursing

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Objective:Neurological complications such as chemotherapy-induced peripheral neuropathy (CIPN) and neuropathic pain are frequent side effects of neurotoxic chemotherapy agents. An increasing survival rate and frequent administration of adjuvant chemotherapy treatments involving neurotoxic agents makes it imperative that accurate diagnosis, prevention, and treatment of these neurological complications be implemented.Methods:A consideration was undertaken of the current options regarding protective and treatment interventions for patients undergoing chemotherapy with neurotoxic chemotherapy agent or experience with CIPN. Current knowledge on the mechanism of action has also been identified. The following databases PubMed, the Cochrane Library, Science Direct, Scopus, EMBASE, MEDLINE, CINAHL, CNKI, and Google Scholar were searched for relevant article retrieval.Results:A range of pharmaceutical, nutraceutical, and herbal medicine treatments were identified that either showed efficacy or had some evidence of efficacy. Duloxetine was the most effective pharmaceutical agent for the treatment of CIPN. Vitamin E demonstrated potential for the prevention of cisplatin-IPN. Intravenous glutathione for oxaliplatin, Vitamin B6 for both oxaliplatin and cisplatin, and omega 3 fatty acids for paclitaxel have shown protection for CIPN. Acetyl-L-carnitine may provide some relief as a treatment option. Acupuncture may be of benefit for some patients and Gosha-jinki-gan may be of benefit for protection from adverse effects of oxaliplatin induced peripheral neuropathy.Conclusions:Clinicians and researchers acknowledge that there are numerous challenges involved in understanding, preventing, and treating peripheral neuropathy caused by chemotherapeutic agents. New insights into mechanisms of action from chemotherapy agents may facilitate the development of novel preventative and treatment options, thereby enabling medical staff to better support patients by reducing this debilitating side effect.

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Section: Resultsmentioning

confidence: 99%

“…[4] A recent review by Boyette-Davis et al . [4] identified a number of different mechanisms of actions for CIPN [Table 1]. …”

Section: Resultsmentioning

confidence: 99%

New Insights into Potential Prevention and Management Options for Chemotherapy-Induced Peripheral Neuropathy

Schloss

Colosimo

Vitetta

2016

Asia-Pacific Journal of Oncology Nursing

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“…24,[49][50][51][52] Exercise may ameliorate treatment-related or stressrelated chronic inflammation, 53,54 oxidative stress, 55,56 impaired neurotransmission, 57,58 or cytokine and hormonal derangements. Yet our results suggest that even small amounts of vigorous exercise may ameliorate these outcomes.…”

Section: Discussionmentioning

confidence: 99%

Impact of exercise on psychological burden in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study

Tonorezos

Ford

Wang

et al. 2019

Cancer

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BACKGROUND: Childhood cancer survivors are at risk for adverse psychological outcomes. Whether exercise can attenuate this risk is unknown. METHODS: In total, 6199 participants in the Childhood Cancer Survivor Study (median age, 34.3 years [range, 22.0-54.0 years]; median age at diagnosis, 10.0 years [range, 0-21.0 years]) completed a questionnaire assessing vigorous exercise and medical/psychological conditions. Outcomes were evaluated a median of 7.8 years (range, 0.1-10.0 years) later and were defined as: symptom level above the 90th percentile of population norms for depression, anxiety, or somatization on the Brief Symptom Inventory-18; cancer-related pain; cognitive impairment using a validated self-report neurocognitive questionnaire; or poor healthrelated quality of life. Log-binomial regression estimated associations between exercise (metabolic equivalent [MET]-hours per week −1 ) and outcomes adjusting for cancer diagnosis, treatment, demographics, and baseline conditions. RESULTS: The prevalence of depression at follow-up was 11.4% (95% CI, 10.6%-12.3%), anxiety 7.4% (95% CI, 6.7%-8.2%) and somatization 13.9% (95% CI, 13.0%-14.9%). Vigorous exercise was associated with lower prevalence of depression and somatization. The adjusted prevalence ratio for depression was 0.87 (95% CI, 0.72-1.05) for 3 to 6 MET hours per week −1 , 0.76 (95% CI, 0.62-0.94) for 9 to 12 MET-hours per week −1 , and 0.74 (95% CI, 0.58-0.95) for 15 to 21 MET-hours per week −1 . Compared with 0 MET hours per week −1 , 15 to 21 MET-hours per week −1 were associated with an adjusted prevalence ratio of 0.79 (95% CI, 0.62-1.00) for somatization. Vigorous exercise also was associated with less impairment in the physical functioning, general health and vitality (P trend < .001), emotional role limitations (P trend = .02), and mental health (P trend = .02) domains as well as higher cognitive function in the domains of task completion, organization, and working memory (P < .05 for all), but not in the domain of cancer pain. CONCLUSIONS: Vigorous exercise is associated with less psychological burden and cognitive impairment in childhood cancer survivors. Cancer 2019;125:3059-3067.

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“…Clinical data revealed that chemotherapy agents, such as oxaliplatin , vincristine , paclitaxel and bortezomib , are a significant cause of peripheral neuropathy (as reviewed by Boyette‐Davis et al . ). Although the mechanisms underlying this effect are poorly understood, chemotherapeutics were found to alter Na V s activity by mobilizing intraneuronal calcium .…”

Section: Exogenous Triggersmentioning

confidence: 97%

Profiling of how nociceptor neurons detect danger – new and old foes

et al. 2019

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The host evolves redundant mechanisms to preserve physiological processing and homeostasis. These functions range from sensing internal and external threats, creating a memory of the insult and generating reflexes, which aim to resolve inflammation. Impairment in such functioning leads to chronic inflammatory diseases. By interacting through a common language of ligands and receptors, the immune and sensory nervous systems work in concert to accomplish such protective functions. Whilst this bidirectional communication helps to protect from danger, it can contribute to disease pathophysiology. Thus, the somatosensory nervous system is anatomically positioned within primary and secondary lymphoid tissues and mucosa to modulate immunity directly. Upstream of this interplay, neurons detect danger, which prompts the release of neuropeptides initiating (i) defensive reflexes (ranging from withdrawal response to coughing) and (ii) chemotaxis, adhesion and local infiltration of immune cells. The resulting outcome of such neuro‐immune interplay is still ill‐defined, but consensual findings start to emerge and support neuropeptides not only as blockers of TH1‐mediated immunity but also as drivers of TH2 immune responses. However, the modalities detected by nociceptors revealed broader than mechanical pressure and temperature sensing and include signals as various as cytokines and pathogens to immunoglobulins and even microRNAs. Along these lines, we aggregated various dorsal root ganglion sensory neuron expression profiling datasets supporting such wide‐ranging sensing capabilities to help identifying new danger detection modalities of these cells. Thus, revealing unexpected aspects of nociceptor neuron biology might prompt the identification of novel drivers of immunity, means to resolve inflammation and strategies to safeguard homeostasis.

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Mechanisms Involved in the Development of Chemotherapy-Induced Neuropathy

Cited by 146 publications

References 129 publications

New Insights into Potential Prevention and Management Options for Chemotherapy-Induced Peripheral Neuropathy

New Insights into Potential Prevention and Management Options for Chemotherapy-Induced Peripheral Neuropathy

Impact of exercise on psychological burden in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study

Profiling of how nociceptor neurons detect danger – new and old foes

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