Mechanisms of Cadmium Carcinogenicity in the Gastrointestinal Tract

Bishak, Yaser Khaje; Payahoo, Laleh; Osatdrahimi, Alireza; Nourazarian, Alireza

doi:10.7314/apjcp.2015.16.1.9

Cited by 74 publications

(34 citation statements)

References 152 publications

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“…Exposure to cadmium has been associated with carcinogenesis in multiple tissues including breast, esophagus, stomach, intestines, prostate, lungs and testes [41,45,46]. Cadmium also has a proposed role in the development of cancer in the gallbladder.…”

Section: Cadmiummentioning

confidence: 99%

“…Similar to other heavy metals, carcinogenic mechanisms associated with cadmium include generation of ROS, epigenetic alterations, inhibiting DNA repair processes and apoptosis [41,46,52,53]. It has been demonstrated that both chronic and acute cadmium exposure has the ability to induce changes in gene regulation, which generates an increased risk for malignant growth [44].…”

Section: Cadmiummentioning

confidence: 99%

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Heavy Metals and Cancer

Carver¹,

Gallicchio²

2018

Cancer Causing Substances

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There has been increased concern surrounding exposure to heavy metals due to the evolving understanding of their role in the development of cancer. This review highlights research related to the impact that heavy metals aluminum, arsenic, beryllium, cadmium, lead, mercury, nickel and radium have on human health. Research was collected through PubMed, and it was compiled to assess the current knowledge of exposure sources, types of cancers induced and therapeutic measures for these metals. Furthermore, it was designed to assist in guiding future research efforts with respect to heavy metals and cancer.

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Section: Cadmiummentioning

confidence: 99%

Section: Cadmiummentioning

confidence: 99%

Heavy Metals and Cancer

Carver¹,

Gallicchio²

2018

Cancer Causing Substances

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“…Also, it has been proven that cadmium increases the production of free radicals in cells by interfering with antioxidant enzymes, removing sulfhydryl groups' bands by glutathione and substitution with copper, zinc and iron in proteins and reduces some antioxidants such as catalase, Super Oxide Dismutase (SOD) and glutathione reductase and glutathione peroxidase due to having thiols and causes lipid peroxidation (20). This causes impairing cell growth and differentiation, inhibiting apoptotic mechanisms, blocking repair mechanisms of DNA, signaling pathway and gene expression (36).…”

Section: H a Abedi Et Al J Fundam Appl Sci 2016 8(4s) 2008-2022mentioning

confidence: 99%

Evaluating the effect of aqueous extract of the roots of native edible asparagus in Iran (<i>Asparagus officinalis</i> L) on the concentration of liver factors in male rats treated with cadmium chloride

Abedi¹,

Jahromi²,

Sadeghi³

et al. 2016

J. Fundam and Appl Sci.

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Abstract:Introduction: Cadmium is of the environmental pollutants and is considered as a part of the list of 126 top elements of environmental pollutants which has a long half-life in the body and is estimated at about 10 to 30 years. The use of herbal medicines because of having many antioxidants and lack of side effects is increasing in the today world to be a good alternative for chemical drugs. So the objective of the present study is to evaluate the effect of aqueous extract of the root of native edible asparagus in Iran (Asparagus officinalis L.) on the concentration of liver enzymes in male rats exposed to cadmium chloride.Method: 72 male rats were accidentally divided into the control, sham and test groups (100 mg/kg asparagus extract, 200 mg/kg asparagus extract, 400 mg/kg asparagus extract, 5 mg/kg cadmium chloride, cadmium chloride and 100 mg/kg asparagus extract, cadmium chloride and Abstract:Introduction: Cadmium is of the environmental pollutants and is considered as a part of the list of 126 top elements of environmental pollutants which has a long half-life in the body and is estimated at about 10 to 30 years. The use of herbal medicines because of having many antioxidants and lack of side effects is increasing in the today world to be a good alternative for chemical drugs. So the objective of the present study is to evaluate the effect of aqueous extract of the root of native edible asparagus in Iran (Asparagus officinalis L.) on the concentration of liver enzymes in male rats exposed to cadmium chloride. EVALUATING THE EFFECT OF AQUEOUS EXTRACT OF THE ROOTS OF NATIVE EDIBLE ASPARAGUS IN IRAN (ASPARAGUS OFFICINALIS L) ON THE CONCENTRATION OF LIVER FACTORS IN MALE RATS TREATED Abstract:Introduction: Cadmium is of the environmental pollutants and is considered as a part of the list of 126 top elements of environmental pollutants which has a long half-life in the body and is estimated at about 10 to 30 years. The use of herbal medicines because of having many antioxidants and lack of side effects is increasing in the today world to be a good alternative for chemical drugs. So the objective of the present study is to evaluate the effect of aqueous extract of the root of native edible asparagus in Iran (Asparagus officinalis L.) on the concentration of liver enzymes in male rats exposed to cadmium chloride.Method: 72 male rats were accidentally divided into the control, sham and test groups (100 mg/kg asparagus extract, 200 mg/kg asparagus extract, 400 mg/kg asparagus extract, 5 mg/kg cadmium chloride, cadmium chloride and 100 mg/kg asparagus extract, cadmium chloride and H .A. Abedi et al. J Fundam Appl Sci. 2016, 8(4S), 2008-2022 200 mg/kg asparagus extract, cadmium chloride and 400 mg/kg asparagus extract). All injections were performed by gavage for 28 consecutive days. One-Way ANOVA and Duncan at the significance level of 5% were used for statistical analysis.Results: Cadmium chloride increased the averages of serum ALT, AST, ALP and bilirubin significantly and decreased the averages of se...

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“…Colorectal cancer (CRC) is the third most common cancer and the fourth most universal cause of cancer‐related death globally . CRC is a complex disease influenced both by genetic factors and by environmental factors . As for bridging factors of genetics and environment, epigenetic modifications modulate gene expression .…”

Section: Introductionmentioning

confidence: 99%