Mechanisms of Delayed Wound Healing by Commonly Used Antiseptics

Thomas, Gregory W.; Rael, Leonard T.; Bar-Or, Raphael; Shimonkevitz, Richard; Mains, Charles W.; Slone, Denetta S.; Craun, Michael L.; Bar‐Or, David

doi:10.1097/ta.0b013e31818b146d

Cited by 116 publications

(122 citation statements)

References 35 publications

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“…In addition, the killing ability of H 2 O 2 on pathogenic bacteria like Pseudomonas aeruginosa is doubtful because catalases are reported to exist in their bodies [55] . H 2 O 2 is also used regularly to prepare the bony bed in cemented arthroplasties as well as to achieve hemostasis in neurosurgery [56,57] .…”

Section: Current Clinical Use Of Hydrogen Peroxidementioning

confidence: 99%

Hydrogen Peroxide: A Potential Wound Therapeutic Target

Zhu¹,

Wang²,

Lu³

et al. 2017

Med Princ Pract

114

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Hydrogen peroxide (H2O2) is a topical antiseptic used in wound cleaning which kills pathogens through oxidation burst and local oxygen production. H2O2 has been reported to be a reactive biochemical molecule synthesized by various cells that influences biological behavior through multiple mechanisms: alterations of membrane potential, generation of new molecules, and changing intracellular redox balance, which results in activation or inactivation of different signaling transduction pathways. Contrary to the traditional viewpoint that H2O2 probably impairs tissue through its high oxidative property, a proper level of H2O2 is considered an important requirement for normal wound healing. Although the present clinical use of H2O2 is still limited to the elimination of microbial contamination and sometimes hemostasis, better understanding towards the sterilization ability and cell behavior regulatory function of H2O2 within wounds will enhance the potential to exogenously augment and manipulate healing.

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Section: Current Clinical Use Of Hydrogen Peroxidementioning

confidence: 99%

Hydrogen Peroxide: A Potential Wound Therapeutic Target

Zhu¹,

Wang²,

Lu³

et al. 2017

Med Princ Pract

114

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“…Wound management entails a hospital stay of specific duration, expensive medication and various surgical modalities followed by a long process of rehabilitation (Thomas et al 2009). Most topical antibacterial agents and disinfectants are effective in protecting against infections, but the occurrence of irritations in the skin and allergy due to these agents reduces the rate of skin regeneration and increases the time needed for complete recovery (Burks 1998).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Chromolaena odorata leaf extracts for the healing of rat excision wounds

Vijayaraghavan¹,

Rajkumar²,

Ali-Seyed³

2017

Vet. Med.

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Injury to the soft tissues is followed by wound healing, which consists of four stages: haemostasis, inflammation, proliferation and remodelling. Chromolaena odorata is a weed that is traditionally used for the treatment of various ailments in humans and animals. The present study was aimed at exploring the wound healing potential of aqueous and ethanolic extracts of C. odorata in a rat excision wound model. This investigation involved phytochemical screening and in vitro analyses of various parameters such as antioxidant activity, lipid peroxide inhibitory activity and the effects of extracts on contraction and epithelialisation of the rat excision wounds. The phytochemical screening of both ethanolic and aqueous extracts showed that they were rich in secondary metabolites such as alkaloids, flavonoids, tannins, saponins, terpenoids, anthraquinones, cardiac glycosides and carbohydrates. The aqueous extract showed high antioxidant and lipid peroxide inhibitory activity, while the ethanolic extract showed high total phenol content and hydrogen peroxide inhibitory activity at concentrations of 50, 100 and 250 μg/ml. Our results also indicate that the most effective concentration of the C. odorata extract for excision wound healing was 5.0% (w/w). C. odorata-treated groups exhibited a faster reduction in wound area compared to control and Betadine-treated groups. In addition, the topical application of C. odorata extract increased collagen synthesis and its stabilisation at the wound site, as evidenced by the increase in hydroxyproline and hexosamine levels and expression of collagen. The present investigation demonstrates that aqueous and ethanolic extracts of C. odorata of varying concentrations promote an accelerated wound healing process and might represent a novel healing agent. Our findings are of potential clinical relevance and might be highly beneficial for drug discovery and development in the area of both human and veterinary medicine.

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“…On the other hand, there is no consensus amongst wound care authorities on the advantages of using sterile solutions over non-sterile solutions. Research has also established that the use of antiseptic solutions may compromise the healing process (Thomas et al, 2009) and, as a result, the use of normal saline as a cleansing solution is widely recommended (Lawrence, 1997). In fact, preparations with antiseptic properties have also been traditionally used since the earliest times; however, published research has suggested that antiseptic solutions may hinder the healing process.…”

Section: Introductionmentioning

confidence: 99%

A eficácia das soluções de limpeza para o tratamento de feridas: uma revisão sistemática

Santos¹,

Queirós²,

Cardoso³

et al. 2016

Rev. Enf. Ref

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ResumoResumen R E V I E W P A P E R The effectiveness of cleansing solutions for wound treatment: a systematic reviewA eficácia das soluções de limpeza para o tratamento de feridas: uma revisão sistemática La eficacia de las soluciones de limpieza para el tratamiento de heridas: una revisión sistemática Eduardo Santos*; Paulo Queirós**; Daniela Cardoso***; Madalena Cunha****; João Apóstolo*****Background: There is a consensus that wound cleansing reduces infection rates. There is, however, some debate in clinical circles about the potential advantages and disadvantages of cleansing wounds. Objectives: To identify and synthesize the best available evidence on the effectiveness of cleansing solutions for wound treatment.Review method: This systematic review followed the Joanna Briggs Institute methodology and included studies that considered patients with chronic and acute wounds. Critical appraisal, extraction and synthesis of data were performed by two independent reviewers. Results: Three randomized clinical trials (n=718) were included and the results of the meta-analysis showed no difference in the wound infection for the Tap Water versus Sterile Saline comparison (OR=0,79; 95% Cl= 0,72; p=0,55). For acute wounds, the odds ratio was 0,98 (95% CI= 0,43-2,25). Conclusion: There is no evidence that using tap water to cleanse acute and chronic wounds in adults increases infection or healing rates. There may be a trend towards a lower wound infection rate when povidone-iodine is used in surgical wounds.

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Mechanisms of Delayed Wound Healing by Commonly Used Antiseptics

Cited by 116 publications

References 35 publications

Hydrogen Peroxide: A Potential Wound Therapeutic Target

Hydrogen Peroxide: A Potential Wound Therapeutic Target

Efficacy of Chromolaena odorata leaf extracts for the healing of rat excision wounds

A eficácia das soluções de limpeza para o tratamento de feridas: uma revisão sistemática

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