Mechanisms of function and clinical potential of exosomes in esophageal squamous cell carcinoma

Zhao, Lijun; Yu, Lili; Wang, Xiangpeng; He, Jangtao; Zhu, Xiaofei; Zhang, Rui; Yang, An‐Gang

doi:10.1016/j.canlet.2022.215993

Cited by 13 publications

(7 citation statements)

References 169 publications

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“…For example, relevant research focuses on ncRNAs in exosomes, because as a subgroup of tumor microenvironment, it promotes cell communication by transmitting various biological molecules [ 55 ]. Exosomes carrying ncRNAs, due to their stability and widespread presence in body fluids, along with advancements in exosome separation technology, are expected to make the detection of ncRNAs for screening ESCC patients non-invasive, convenient, and efficient [ 56 ]. In addition, studies have also focused on the immune landscape related to ncRNAs in ESCC, which will be of great significance in revealing the tumor immune microenvironment.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive landscape and future perspectives of non-coding RNAs in esophageal squamous cell carcinoma, a bibliometric analysis from 2008 to 2023

Wu,

Wang,

Cheng

et al. 2024

Pathol. Oncol. Res.

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Objectives: Summarize the progress and hot topic evolution of non-coding RNAs (ncRNAs) research in esophageal squamous cell carcinoma (ESCC) in recent years and predict future research directions.Methods: Relevant articles from the Web of Science until 31 October 2023 were obtained. Bibliometric analysis of included articles was performed using software (VOSviewer, CiteSpace, and Bibliometrix). The volume and citation of publications, as well as the country, institution, author, journal, keywords of the articles were used as variables to analyze the research trends and hot spot evolution.Results: 1,118 literature from 2008 to 2023 were retrieved from database, with 25 countries/regions, 793 institutions, 5,426 authors, 261 journals involved. Global cooperation was centered on China, Japan, and the United States. Zhengzhou University, an institution from China, had the highest publication. The most prolific author was Guo Wei, and the most prolific journal was Oncology Letters. Analysis of keywords revealed that the research in this field revolved around the role of ncRNAs in the occurrence, development, diagnosis, treatment, and prognosis of ESCC, mainly including micro RNAs, long non-coding RNAs, and then circular RNAs.Conclusion: Overall, research on ncRNAs in ESCC remains strong. Previous research has mainly focused on the basic research, with a focus on the mechanism of ncRNAs in the occurrence, development, diagnosis, treatment, and prognosis of ESCC. Combining current research with emerging disciplines to further explore its mechanisms of action or shifting the focus of research from preclinical research to clinical research based on diagnosis, treatment, and prognosis, will be the main breakthrough in this field in the future.

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Section: Discussionmentioning

confidence: 99%

Comprehensive landscape and future perspectives of non-coding RNAs in esophageal squamous cell carcinoma, a bibliometric analysis from 2008 to 2023

Wu,

Wang,

Cheng

et al. 2024

Pathol. Oncol. Res.

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“…[128] However, these studies mainly included small sample numbers and were single-centre studies, thus lacking authoritative clinical data for evaluating the potential application of miRNAs in early ESCC diagnosis. Moreover, long noncoding RNAs, [129] exosomes, [130,131] circular RNAs, [132] and circulating tumor DNAs [133] were also evaluated as potential serum markers for the early detection of ESCC. Transcriptome profiling revealed that a large number of LncRNAs were dysregulated in ESCCs.…”

Section: Biomarkersmentioning

confidence: 99%

Advances in the Theranostics of Oesophageal Squamous Carcinoma

Cheng

et al. 2023

Advanced Therapeutics

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Oesophageal squamous carcinoma (ESCC) is one of the most lethal human malignancies, and it is a more aggressive form of oesophageal cancer (EC) that comprises over 90% of all EC cases in China compared with oesophageal adenocarcinoma (EAC). The high mortality of ESCC is attributed to the late‐stage diagnosis, chemoradiotherapy resistance, and lack of appropriate therapeutic targets and corresponding therapeutic formulations. Recently, emerging clinical and translational investigations have involved genome analyses, diagnostic biomarkers, and targeted therapy for ESCC, and these studies provide a new horizon for improving the clinical outcomes of patients with ESCC. Here, the latest research advances in the theranostics of ESCC are reviewed and the unique features of ESCC (including differences from EAC, genomic alterations, and microbe infections), tissue and circulating biomarkers, chemoradiotherapy resistance, clinical targeted therapy for ESCC, identification of novel therapeutic targets, and designation of nanotherapeutic systems for ESCC are particularly focused on. Finally, the perspectives for future clinical and translational theranostic research of ESCC are discussed and the obstacles that must be overcome in ESCC theranostics are described.

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“…ESCC-derived exosomal miR-301a-3p induced macrophage polarization into the M2 type via the inhibition of PTEN and activation of the PI3K/AKT signalling pathway, subsequently promoting angiogenesis via the secretion of VEGFA and MMP9 [ 91 ]. In addition to proangiogenesis, the antiangiogenesis of exosomes in ESCC cells has also been described [ 92 ]. Specifically, miR-154-5p overexpression in exosomes inhibited angiogenesis in vitro, as indicated by the inhibition of tube formation in HUVECs.…”

Section: Introductionmentioning

confidence: 99%

Research progress of exosomes in the angiogenesis of digestive system tumour

Liu,

Wu,

Sang

et al. 2024

Discov Onc

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Malignant tumours of the digestive system cover a wide range of diseases that affect the health of people to a large extent. Angiogenesis is indispensable in the development, and metastasis of tumours, mainly in two ways: occupation or formation. Vessels can provide nutrients, oxygen, and growth factors for tumours to encourage growth and metastasis, so cancer progression depends on simultaneous angiogenesis. Recently, exosomes have been proven to participate in the angiogenesis of tumours. They influence angiogenesis by binding to tyrosine kinase receptors (VEGFR)-1, VEGFR-2, and VEGFR-3 with different affinities, regulating Yap-VEGF pathway, Akt pathway or other signaling pathway. Additionally, exosomes are potential therapeutic vectors that can deliver many types of cargoes to different cells. In this review, we summarize the roles of exosomes in the angiogenesis of digestive system tumours and highlight the clinical application prospects, directly used as targers or delivery vehicles, in antiangiogenic therapy.

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Mechanisms of function and clinical potential of exosomes in esophageal squamous cell carcinoma

Cited by 13 publications

References 169 publications

Comprehensive landscape and future perspectives of non-coding RNAs in esophageal squamous cell carcinoma, a bibliometric analysis from 2008 to 2023

Comprehensive landscape and future perspectives of non-coding RNAs in esophageal squamous cell carcinoma, a bibliometric analysis from 2008 to 2023

Advances in the Theranostics of Oesophageal Squamous Carcinoma

Research progress of exosomes in the angiogenesis of digestive system tumour

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