2014
DOI: 10.1371/journal.pone.0093973
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Mechanisms of Nerve Capping Technique in Prevention of Painful Neuroma Formation

Abstract: Nerve capping techniques have been introduced as a promising treatment modality for the treatment of painful neuroma with varied outcomes; however, its exact mechanism is still unknown. RhoA is one of the members of the RAS superfamily of GTPases that operate as molecular switches and plays an important role in peripheral nerve regeneration. Our aim was to investigate the structural and morphologic mechanisms by which the nerve capping technique prevents the formation of painful neuromas after neuroectomy. We … Show more

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Cited by 46 publications
(71 citation statements)
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“…Morphological analysis is the most commonly used method, usually performed in light, 18,22,24,26,27,29,45,46,32,34,50,36,38,43,44,49,19,20,47,39,49 electron, 10,30,32,50,36,40 fluorescence 19,37,38,40 or confocal laser microscopy. 20,43,44 Data on the level where biopsies of the nerve and the neuroma are taken and analysed are heterogeneous and often missing, preventing appropriate comparison of results: Chim et al 16 Haematoxylin and eosin 16,18e20,36,50,37,40,49 and toluidine blue 10,18,22,32,45,46,24,19,25,27,30,38,43,…”
Section: Evaluation Methods Histologymentioning
confidence: 99%
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“…Morphological analysis is the most commonly used method, usually performed in light, 18,22,24,26,27,29,45,46,32,34,50,36,38,43,44,49,19,20,47,39,49 electron, 10,30,32,50,36,40 fluorescence 19,37,38,40 or confocal laser microscopy. 20,43,44 Data on the level where biopsies of the nerve and the neuroma are taken and analysed are heterogeneous and often missing, preventing appropriate comparison of results: Chim et al 16 Haematoxylin and eosin 16,18e20,36,50,37,40,49 and toluidine blue 10,18,22,32,45,46,24,19,25,27,30,38,43,…”
Section: Evaluation Methods Histologymentioning
confidence: 99%
“…20,43,44 Data on the level where biopsies of the nerve and the neuroma are taken and analysed are heterogeneous and often missing, preventing appropriate comparison of results: Chim et al 16 Haematoxylin and eosin 16,18e20,36,50,37,40,49 and toluidine blue 10,18,22,32,45,46,24,19,25,27,30,38,43,44 are the most commonly used stains; some studies also use Masson's thricome, 10,20,37 which also allows the labelling of the connective tissue. 70 This is sometimes combined with immunolabelling, the most common targets being S100 protein, 16,25e27,43 neurofilament 200 (NF200), 10,25,30,37,38 neuronal growthassociated protein (GAP)-43, 20,24,43,44 macrophages (ED-1), 20,27,28,43 nerve growth factor (NGF) 27 and calcitonin gene-related peptide (CGRP). 24,28,30 Double staining has also been reported to identify axons of different origin.…”
Section: Evaluation Methods Histologymentioning
confidence: 99%
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“…Additionally, an increase in smaller disorganized myelinated fibers was observed post-treatment indicating the formation of nerve sprouts occurring within the neuroma [68]. Currently, various techniques for the prevention of neuroma formation are being studied with varying outcomes [67,69].…”
Section: Surgical Transectionmentioning
confidence: 99%
“…Finally, a bulbous tissue (neuroma) is formed 8. Within the neuroma, many regenerated axons are surrounded by abnormal myelin sheath, exhibiting variable degrees of thickening, which alters the electrophysiological properties of axons and renders them hypersensitive to mechanical, chemical, and physical stimuli 9. Even worse, this hyperpathia can intensify by the factors that release at the stage of immune reaction, such as monocyte chemoattractant protein‐1, interleukin‐1 (IL‐1), and tumor necrosis factor‐alpha (TNF‐α) 10.…”
Section: Introductionmentioning
confidence: 99%