Mechanisms underlying the hepatoprotective effect of silymarin on fluoxetine-induced liver injury in rats: the implication of peroxisome proliferator–activated receptor-gamma (PPAR-γ)

Milk thistle protects against non-alcoholic fatty liver disease induced by dietary thermally oxidized tallow

“…Our work, however, agrees with the study of Zhu et al [ 55 ], who showed that HFD caused a decline in liver PPARα levels, which were enhanced by the oils from MT. Our findings are also in agreement with the study of Mohamed Kamel et al [ 56 ], who showed that MT upregulated PPARγ expression and was protective in the liver. Therefore, a high-fat diet consisting of tallow or lard causes NAFLD, which can be ameliorated by MT extract activation of PPARα and PPARγ in the liver.…”