Mechanistic analysis of erectile dysfunction in a depression rat model

Hong, Zhi-ming; Chen, Zilong; Feng, Junlong; Wang, Shengjie; Qiu, Jun-feng; Zeng, Yang-ling; Wang, Quan; Wang, Jisheng

doi:10.1177/03000605221100334

Cited by 7 publications

(2 citation statements)

References 30 publications

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“…Both ED and the abnormal relaxation of the cavernous muscles of the penis were found to be caused by the overproduction of catecholamines, which was influenced by depression. In addition, the dopamine system and the dopaminergic synapse signaling pathway were abnormal in the rat model of depression [48].…”

Section: Discussionmentioning

confidence: 99%

Low Exercise Tolerance as a Marker of Erectile Dysfunction and Depression among Post-Myocardial Infarction Men

et al. 2023

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Evidence has grown recently on the correlation between lifestyle and physical activity, and their impact on the functioning of the entire organism. In addition, a decrease in physical efficiency may be an indicator of the early diagnosis of systemic diseases. The aim of this study was to determine whether there is a relationship between exercise tolerance and possible erectile dysfunction or mental disorders. A cross-sectional study was conducted among 254 men in 4 cardiac rehabilitation centers in Poland using the standardized International Index of Erectile Function 5 (IIEF-5) and Beck Depression Inventory (BDI) questionnaires. Erectile dysfunction was directly proportional to the metabolic equivalent of the task (MET) variable. An increase in exercise tolerance by 1 point was associated with an increase in the IIEF-5 score by 1.62 points, indicating a reduction in the severity of erectile dysfunction. The 1-point increase in MET was associated with a 1.8-point decrease in BDI, indicating that an increase in exercise tolerance is associated with a decrease in the severity of depressive disorders. Increasing the tolerance of physical effort has a beneficial effect not only on the general well-being, but also on the sexual and mental health of men. An increase in exercise tolerance is associated with a reduction in the incidence of erectile dysfunction. On the other hand, in patients with depressive disorders, the improvement of exercise tolerance reduces the intensity of depression symptoms. Exercise tolerance can be an early and simple marker at the onset of erectile dysfunction or mood disorders.

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Section: Discussionmentioning

confidence: 99%

Low Exercise Tolerance as a Marker of Erectile Dysfunction and Depression among Post-Myocardial Infarction Men

et al. 2023

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“…The dysfunction of the dopaminergic system is also an important cause of ED in depression model rats. The expression of dopamine receptor D2 and transporter solute carrier family 6 member 3 (SLC6A3) in the penis was decreased, and the catechol-O-methyltransferase (COMT) was increased in the depression model rats ( 73 ). Meanwhile, negative emotions led to the overactivation of adrenergic fibres, which release norepinephrine to act on α-receptors of the smooth muscle of the corpus cavernosum, activated RhoA/ROCK pathway to cause smooth muscle contraction, and inhibited penile erection ( 4 ).…”

Section: The Physiology Of Penile Erection and The Pathophysiology Of Edmentioning

confidence: 99%

The role of microRNAs in erectile dysfunction: From pathogenesis to therapeutic potential

et al. 2022

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Erectile dysfunction (ED) is a common male sexual dysfunction disease, and it was predicted that the number of ED patients worldwide will reach 322 million by 2025. However, the pathogenesis of ED is complex and the current treatment options are still limited, so it is urgent to explore new treatment strategies. Recent studies have shown that microRNAs (miRNAs) play an important role in ED, and these single-stranded non-coding small RNA molecules are involved in key pathophysiological processes in the occurrence and development of ED. Therefore, miRNAs have remarkable potential as therapeutic targets in ED. Here, this review introduces the physiological basis of erectile function and the pathophysiological changes in ED and summarizes the current knowledge on the expression, biological functions, and molecular mechanisms of miRNAs in ED, especially the potential of miRNA-targeted therapies to improve ED. This review will provide a comprehensive view of the role of miRNAs in the pathogenesis of ED and the potential value of miRNAs in the treatment of ED.

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